Elucidating the neural pathways and genetic basis of speech. The project will elucidate the biological basis of speech, a unique feature of the human condition. The project will do this by i) discovering genes associated with speech disorder and ii) defining the neural pathways associated with speech production. This study will address critical questions regarding gene, brain and behaviour relationships in speech.
Discovery Early Career Researcher Award - Grant ID: DE130101290
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Age-related reorganisation of cortical networks subserving memory retrieval. This research project will use brain imaging to understand how the brain reorganises working memory when it ages. It will provide a framework for understanding age-related memory decline in the brain, which will in turn provide key information for understanding memory difficulties in clinical populations.
The structure and function of the human spinal connectome. This project will use complex network analysis to map the interactions between the brain and body, to understand how the central nervous system controls our movements. The project will provide fundamental insights into mechanisms that coordinate activity in the human motor system, and how the breakdown of coordination may lead to movement disorders. By integrating advanced computational analyses with state-of-the-art recording techniques ....The structure and function of the human spinal connectome. This project will use complex network analysis to map the interactions between the brain and body, to understand how the central nervous system controls our movements. The project will provide fundamental insights into mechanisms that coordinate activity in the human motor system, and how the breakdown of coordination may lead to movement disorders. By integrating advanced computational analyses with state-of-the-art recording techniques, the project will generate new knowledge of the neural basis of human motor coordination. Expected outcomes may support future applications to restore motor function through brain stimulation, prosthetics and robotics design.Read moreRead less
Spontaneous activity and neural decoding in the developing brain. This project aims to investigate how patterns of neural activity emerge in the developing brain, using the zebrafish as a model system. This project expects to generate new knowledge regarding the functional significance of spontaneously generated activity, and how it interacts with sensory experience. The expected outcomes of this project include enhanced capacity at the interface between neuroscience and computation. This should ....Spontaneous activity and neural decoding in the developing brain. This project aims to investigate how patterns of neural activity emerge in the developing brain, using the zebrafish as a model system. This project expects to generate new knowledge regarding the functional significance of spontaneously generated activity, and how it interacts with sensory experience. The expected outcomes of this project include enhanced capacity at the interface between neuroscience and computation. This should provide significant benefits including greater insight into normal brain development, and the formulation of new concepts potentially relevant for brain-inspired computing.Read moreRead less
How does environmental enrichment affect brain development? This project aims to use brain imaging and advanced computational analyses to investigate how early sensory experience affects brain development. It adopts the larval zebrafish as a model system, since they display sophisticated behaviours from an early age, and neural activity can be recorded at whole-brain scale with single neuron resolution. The project aims to generate new knowledge regarding environmental effects on brain developme ....How does environmental enrichment affect brain development? This project aims to use brain imaging and advanced computational analyses to investigate how early sensory experience affects brain development. It adopts the larval zebrafish as a model system, since they display sophisticated behaviours from an early age, and neural activity can be recorded at whole-brain scale with single neuron resolution. The project aims to generate new knowledge regarding environmental effects on brain development and behaviour. This will provide significant benefits including greater insight into normal brain development, and the formulation of new concepts potentially relevant for brain-inspired computing. The expected outcomes also include enhanced capacity at the interface between neuroscience and computation.Read moreRead less
How do patterns of brain activity emerge during early life? This project uses theory and experiment to investigate how neural coding emerges in the developing brain. It adopts the larval zebrafish as a model system, because neural activity can be recorded at whole-brain scale but with single neuron resolution. The project expects to generate new knowledge regarding how neural activity comes to represent sensory stimuli, and new statistical models for interpreting large-scale patterns of neural a ....How do patterns of brain activity emerge during early life? This project uses theory and experiment to investigate how neural coding emerges in the developing brain. It adopts the larval zebrafish as a model system, because neural activity can be recorded at whole-brain scale but with single neuron resolution. The project expects to generate new knowledge regarding how neural activity comes to represent sensory stimuli, and new statistical models for interpreting large-scale patterns of neural activity. This will provide significant benefits including greater insight into normal brain development, and the formulation of new concepts potentially relevant for brain-inspired computing. The expected outcomes also include enhanced capacity at the interface between neuroscience and computation.Read moreRead less