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Early Detection Of Infants And Young Children With Autism
Funder
National Health and Medical Research Council
Funding Amount
$268,250.00
Summary
Autism is a severely handicapping condition adversely affecting social interaction, communication, behaviour, interests, and activities. Autism requires treatment at an early age (before 4 years). Despite finding that parents notice problems with their child's development within the first 2 years, on average diagnoses are made around 6 years of age. Treatment for autism should begin as early as possible to improve outcome. Diagnosis requires specialist assessment and these services are limited. ....Autism is a severely handicapping condition adversely affecting social interaction, communication, behaviour, interests, and activities. Autism requires treatment at an early age (before 4 years). Despite finding that parents notice problems with their child's development within the first 2 years, on average diagnoses are made around 6 years of age. Treatment for autism should begin as early as possible to improve outcome. Diagnosis requires specialist assessment and these services are limited. Therefore it is not possible to undertake such assessments with all children who have developmental problems. This project therefore proposes to evaluate a method for screening large populations of children for autism, thus enabling timely and more appropriate referral to assessment services. Previous work by the investigators has developed a potential screening tool (DBC Early Screen) for autism in young children under 4 years with developmental delay that has high levels of accuracy in identifying those infants and children who are at risk of autism and require specialist assessment. This project proposes to undertake a community field trial to assess the accuracy and reliability of this early screen and to establish its suitability for wide use as a population screening tool. The preliminary testing of DBC Early Screen demonstrated that a community field trial was feasible. The results of this study will facilitate the referral of infants and young children to specialist autism assessment services, thus enabling the commencement of appropriate early intervention for children and their families from an early age.Read moreRead less
Preventive And Early Intervention Strategies In Emerging Mental Disorders In Young People
Funder
National Health and Medical Research Council
Funding Amount
$2,000,000.00
Summary
The Centre will be developed through the extension of a youth psychiatry clinical research program of international standing across Melbourne and Sydney. The CCRE will have a major impact on the growth and sustainability of clinical research expertise in youth mental health and its translation into clinical practice. Funds will be targeted specifically at two key opportunities in an evolving structure, namely the early career path for emerging young clinical researchers and the need for more inn ....The Centre will be developed through the extension of a youth psychiatry clinical research program of international standing across Melbourne and Sydney. The CCRE will have a major impact on the growth and sustainability of clinical research expertise in youth mental health and its translation into clinical practice. Funds will be targeted specifically at two key opportunities in an evolving structure, namely the early career path for emerging young clinical researchers and the need for more innovative and potent translation of clinical research into the real world of clinical practice. NHMRC CCRE funding will strengthen the ORC initiative by strategically filling gaps in early career development and training, and drive dissemination and translation of research into clinical practice across Australia.Read moreRead less
Rates Of Psychosis Onset In A High Risk Population
Funder
National Health and Medical Research Council
Funding Amount
$310,359.00
Summary
Older studies of people at risk of schizophrenia found that about 35% of them developed psychosis within 1 year. However the risk has decreased lately to as low as 10%. They may still become psychotic but take longer to do so, or they may not develop psychosis at all. We need to study this so that those not “at risk” are not needlessly treated. We will follow up “at risk” people and determine their 6 year outcome. We will do scans to see if there are any brain changes associated with psychosis.
Novel Morphological Retinal Vascular Features As Early Biomarkers Of Vision-threatening Eye Diseases.
Funder
National Health and Medical Research Council
Funding Amount
$107,169.00
Summary
Vision loss is not just a personal health burden, but a huge socio-economical burden. Management of major vision-threatening eye diseases such as diabetic retinopathy, age-related macular degeneration and glaucoma will be improved if we can successfully identified persons at risk of developing the disease before clinical presentation to benefit from preventive treatment. My research aims to contribute to the prediction of these blinding diseases using advanced computer imaging analysis for simpl ....Vision loss is not just a personal health burden, but a huge socio-economical burden. Management of major vision-threatening eye diseases such as diabetic retinopathy, age-related macular degeneration and glaucoma will be improved if we can successfully identified persons at risk of developing the disease before clinical presentation to benefit from preventive treatment. My research aims to contribute to the prediction of these blinding diseases using advanced computer imaging analysis for simple retinal photographs.Read moreRead less
The Young Learners' Project: Identifying personalised teaching strategies for early literacy in children in preschool and the first year of school. High quality learning experiences coupled with personalised, evidence-based adult support in the preschool years shape children's life-long attitudes and motivation for learning, and form the basis of strong outcomes in adulthood. Of particular importance is the development of literacy. Not all children, however, have such experiences and some need ....The Young Learners' Project: Identifying personalised teaching strategies for early literacy in children in preschool and the first year of school. High quality learning experiences coupled with personalised, evidence-based adult support in the preschool years shape children's life-long attitudes and motivation for learning, and form the basis of strong outcomes in adulthood. Of particular importance is the development of literacy. Not all children, however, have such experiences and some need extra support from their families and teachers. From this study knowledge will be gained that will assist teachers and parents to support children before beginning school so that they are prepared for formal literacy learning. This will lead to greater prospects of financial and social benefits in adulthood. Read moreRead less
Enabling Personalised Risk Assessment For Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Bowel cancer screening will be most effective in disease prevention if it is applied proportionately to individual person's risk. Risk-based screening requires a risk calculator to assess personal risk. By utilising existing large, international datasets, I will identify the risk factors specific for different bowel cancer types and incorporate them to upgrade the prediction model that I have developed. This will achieve more accurate risk prediction to enable personalised risk-based screening.
Pedagogies for eLearning: A Critical Analysis of Strategies for Effective Use of Information and Communications Technologies for Teaching and Learning. This project will assess the potential benefits and weaknesses of 'elearning' in different subject areas and across a range of social settings (including socio-economic, gender and other critical aspects of learner diversity). It will trace the microdynamics of traditional classroom as contrasted with elearning, and develop models which most prod ....Pedagogies for eLearning: A Critical Analysis of Strategies for Effective Use of Information and Communications Technologies for Teaching and Learning. This project will assess the potential benefits and weaknesses of 'elearning' in different subject areas and across a range of social settings (including socio-economic, gender and other critical aspects of learner diversity). It will trace the microdynamics of traditional classroom as contrasted with elearning, and develop models which most productively exploit the educational potentials of elearning. No such direct comparisons of teaching and learning has been made before. The results will inform the development of learning environments which most effectively contribute to the formation of fully enabled members of the emerging 'knowledge society'.Read moreRead less
Literacy Teaching in the Changing Communications Environment: Reading and Writing Multimodal and Digital Texts. This project will make a contribution to the updating of literacy pedagogy to meet the needs of learners in a communications environment where digital and multimodal texts are of ever greater significance. It will attempt to develop a 'metalanguage', or educationally accessible way of talking about contemporary texts in the classroom context, which supplements and extends traditional g ....Literacy Teaching in the Changing Communications Environment: Reading and Writing Multimodal and Digital Texts. This project will make a contribution to the updating of literacy pedagogy to meet the needs of learners in a communications environment where digital and multimodal texts are of ever greater significance. It will attempt to develop a 'metalanguage', or educationally accessible way of talking about contemporary texts in the classroom context, which supplements and extends traditional grammatical and literary understandings of the written word. The purpose of this research will be to create a model of literacy teaching which is more relevant to the contemporary communications environment and which students find more engaging.Read moreRead less
What Can Tau Deposition Tell Us About The Appearance Of Subjective And Objective Cognitive Decline In Older Adults?
Funder
National Health and Medical Research Council
Funding Amount
$674,077.00
Summary
Subjective memory concerns are common in older adults, but it is uncertain how they relate to Alzheimer’s disease (AD) biomarkers. Novel neuroimaging techniques have been developed for measuring tau deposition, a hallmark feature of AD. Using this technique, I aim to determine whether tau is sensitive to certain types of subjective concerns. My findings will reveal which concerns are indicative of AD risk, and which arise from unrelated factors, such as inattention or stress.