Vascular Endothelial Dysfunction In Prenatal Life Predisposes To Hypertension In Adult Life
Funder
National Health and Medical Research Council
Funding Amount
$190,007.00
Summary
An intact endothelial lining in the vascular system is important for the normal development and functioning of the cardiovascular system. Nitric oxide is a substance produced by the endothelium which acts on smooth muscle cells to cause relaxation. Recently, nitric oxide has been shown to play an important role in development of the cardiovascular system. This proposal aims to study the impact a dysfunctional endothelial lining, in particular a reduction in nitric oxide synthesis, has on develop ....An intact endothelial lining in the vascular system is important for the normal development and functioning of the cardiovascular system. Nitric oxide is a substance produced by the endothelium which acts on smooth muscle cells to cause relaxation. Recently, nitric oxide has been shown to play an important role in development of the cardiovascular system. This proposal aims to study the impact a dysfunctional endothelial lining, in particular a reduction in nitric oxide synthesis, has on development and control of the cardiovascular system. It is known that a reduction in nitric oxide synthesis, results in an increase in arterial blood pressure and an alteration in development of the smooth muscle cells of vessels. Studies in human populations have shown that individuals of low birth-weight, which is indicative of poor intrauterine development, are predisposed to developing cardiovascular diseases as adults. This study will investigate the impact reduced nitric oxide synthesis in the fetal period has on adult blood pressure. This study will investigate the mechanisms-factors which contribute to altered control and-or structure of heart and blood vessels in the fetus, newborn and adult after inhibition of the nitric oxide synthesis. The major outcomes of this proposal are that a disruption in nitric oxide synthesis during fetal life predisposes the individual to elevated blood pressure in adult life and an increased probability to becoming hypertensive if they are fatter or have a high salt intake.Read moreRead less
Regulation Of Intestinal Stem Cells And Intestinal Growth
Funder
National Health and Medical Research Council
Funding Amount
$419,018.00
Summary
How the small intestine grows is important for preterm babies and those with short bowel syndrome. This study investigates the mechanisms of growth in the normal situation and in animal model of short bowel syndrome. It investigates particular growth pathways that regulate growth and particularly that of intestinal stem cells.
A Scalable Insomnia Program During The Pregnancy And Postpartum Periods: An Effectiveness-Implementation Hybrid Trial
Funder
National Health and Medical Research Council
Funding Amount
$877,335.00
Summary
Persistent sleep problems are common during pregnancy/postpartum periods and have significant consequences. Cognitive behavioural interventions are efficacious for improving sleep but are not currently available in perinatal care. This study examines the effectiveness, cost- effectiveness, and implementation potential of an innovative nonpharmacological intervention for better maternal sleep and wellbeing, with high potential for sustainable integration with routine perinatal care.
Postpartum Depression: Action Towards Causes And Treatment
Funder
National Health and Medical Research Council
Funding Amount
$570,699.00
Summary
We will recruit women into a large international study to identify genetic variants that increase risk of perinatal depression using a mobile app. Women who screen positive will be asked to provide a spit sample for DNA.