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Field of Research : Genetics
Research Topic : post-transcriptional
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  • Funded Activity

    Linkage Projects - Grant ID: LP0455288

    Funder
    Australian Research Council
    Funding Amount
    $90,168.00
    Summary
    Regulation of principal components of the antioxidant system in table grapes. An expanded ?health-claims? system will likely be enacted by Food Standards Australia New Zealand within two years. Horticultural industries are attracted to the promotional ?point of difference? this offers. Many health-promoting compounds are antioxidants, including polyphenols that are abundant in fruit such as grape and citrus. Antioxidants are also involved in the plant's defences against abiotic and biotic stres .... Regulation of principal components of the antioxidant system in table grapes. An expanded ?health-claims? system will likely be enacted by Food Standards Australia New Zealand within two years. Horticultural industries are attracted to the promotional ?point of difference? this offers. Many health-promoting compounds are antioxidants, including polyphenols that are abundant in fruit such as grape and citrus. Antioxidants are also involved in the plant's defences against abiotic and biotic stress. Here, the WA Table Grape industry has committed funds for an APAI to study regulation of antioxidants in relation to nutritional and postharvest qualities. Effects of preconditioning with mild oxidative stresses will be assayed, postharvest, using molecular and biochemical techniques.
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    Funded Activity

    Regulation And Role Of Transcription At The Centromere.

    Funder
    National Health and Medical Research Council
    Funding Amount
    $737,801.00
    Summary
    Every human cell has 46 chromosomes. Chromosomes are structures that carry genes in all our cells. The centromere is an essential component of a chromosome. It controls the process of cell division, and it ensures the equal division of the duplicated chromosomes. Defects in centromere function can result in various genetic diseases and development of cancers. The structure of the centromere is unique and its properties are determined by an array of proteins and other as yet unknown factors that .... Every human cell has 46 chromosomes. Chromosomes are structures that carry genes in all our cells. The centromere is an essential component of a chromosome. It controls the process of cell division, and it ensures the equal division of the duplicated chromosomes. Defects in centromere function can result in various genetic diseases and development of cancers. The structure of the centromere is unique and its properties are determined by an array of proteins and other as yet unknown factors that bind to it. In our preliminary work, we have demonstrated that a novel non-protein component in the form of RNA (which are expressed products of genes) is essential for the binding of key proteins to the centromere. The presence and importance of such an RNA component has not been previously suspected and represents an exciting new mechanism that help to determine the functional and structural integrity of the centromere. In this project, we propose to study the details of this RNA and to define how this RNA-related mechanism operates to ensure the proper assembly and function of the centromere during cell division.
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    Funded Activity

    Linkage Projects - Grant ID: LP0455493

    Funder
    Australian Research Council
    Funding Amount
    $318,368.00
    Summary
    New biotech methods for crop quality assurance. Quality assurance of crop products is a key for Australia to be competitive in the world marketplace. The power of molecular diagnostics has not been applied to this important but neglected part of the produce handling chain. In this project research will be undertaken that will lead to low cost on site assays to test for variety preservation, contamination, and presence of pests and diseases. It employs the tools of genomics and proteomics to p .... New biotech methods for crop quality assurance. Quality assurance of crop products is a key for Australia to be competitive in the world marketplace. The power of molecular diagnostics has not been applied to this important but neglected part of the produce handling chain. In this project research will be undertaken that will lead to low cost on site assays to test for variety preservation, contamination, and presence of pests and diseases. It employs the tools of genomics and proteomics to provide basic understanding of processes which can be developed into cost effective analyses for practical use by industry to ensure quality assurance.
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    Funded Activity

    Linkage Projects - Grant ID: LP0562391

    Funder
    Australian Research Council
    Funding Amount
    $180,000.00
    Summary
    The future of fruit fly control: making the Sterile Insect Technique work for Queensland fruit fly. The future of fruit fly control in Australia lies in the Sterile Insect Technique (SIT): it is the only non-pesticide option that can totally eliminate pest populations. Millions of dollars have already been invested to establish an SIT program against Queensland fruit fly (Q-fly) in southern and eastern Australia, but this program is currently largely ineffective due to the poor performance of t .... The future of fruit fly control: making the Sterile Insect Technique work for Queensland fruit fly. The future of fruit fly control in Australia lies in the Sterile Insect Technique (SIT): it is the only non-pesticide option that can totally eliminate pest populations. Millions of dollars have already been invested to establish an SIT program against Queensland fruit fly (Q-fly) in southern and eastern Australia, but this program is currently largely ineffective due to the poor performance of the mass-reared sterile flies. This project will apply genetic, ecological and technical solutions to the problems facing the current Q-fly control program. Effective control of Q-fly will enhance the international competitiveness of Australia's horticultural industries.
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