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Genomic Analysis Of DNA Binding And Gene Regulation By The Chromatin Remodelling Factor UBF
Funder
National Health and Medical Research Council
Funding Amount
$624,254.00
Summary
Synthesis of ribosomes, the cellular protein synthetic machinery, is the major anabolic event of a growing cell and is frequently dysregulated during disease such as cancer. This grant will examine a protein termed UBF that we think plays an important role in orchestrating the cellular response to dysregulated ribosome biogenesis. By understanding how UBF functions we hope to uncover novel therapeutic approaches to treat diseases associated with ribosome stress .
Regulation Of Ribosomal RNA Gene Chromatin During Malignant Transformation.
Funder
National Health and Medical Research Council
Funding Amount
$882,486.00
Summary
The overarching goal of this proposal is to determine the molecular basis for tumour cell dependence on activated ribosomal RNA gene repeats (rDNA). Our working model posits that rDNA repeats become activated through changes in rDNA chromatin structure that include increased binding of the RNA Polymerase I transcription factor UBF.
Industrial Transformation Training Centres - Grant ID: IC140100032
Funder
Australian Research Council
Funding Amount
$2,119,872.00
Summary
ARC Training Centre for Food and Beverage Supply Chain Optimisation. ARC Training Centre for Food and Beverage Supply Chain Optimisation. With 15 per cent of the Australian workforce involved in food production and annual food exports of $30.5 billion, the food industry is clearly vital to the Australian economy. The National Food Plan White Paper states as a goal for 2025: "The value of Australia's agriculture and food-related exports will have increased by 45 per cent (in real terms), contribu ....ARC Training Centre for Food and Beverage Supply Chain Optimisation. ARC Training Centre for Food and Beverage Supply Chain Optimisation. With 15 per cent of the Australian workforce involved in food production and annual food exports of $30.5 billion, the food industry is clearly vital to the Australian economy. The National Food Plan White Paper states as a goal for 2025: "The value of Australia's agriculture and food-related exports will have increased by 45 per cent (in real terms), contributing to an increase in our gross domestic product." To make these aspirations a reality, safe, sustainable, and cost-effective, food supply chains will be essential. The Training Centre will train the next generation of multi-disciplinary researchers capable of designing and managing these supply chains.Read moreRead less