Population-based Data Linkage To Investigate The Health And Development Of Children Born After IVF
Funder
National Health and Medical Research Council
Funding Amount
$321,972.00
Summary
In Australia 1 in 25 births are conceived from IVF treatment and this is increasing. My research program will use a comprehensive set of linked population data to address key questions in the IVF field following major changes to IVF practice in the last decade. This research (examining fetal growth, birth defects, intellectual disability and school achievement) has the potential to influence clinical practice and will greatly improve the information available for pre-treatment counselling.
Recent Changes In IVF Clinical Practice: Data Linkage To Investigate Their Impact On Fetal Growth And Birth Defects.
Funder
National Health and Medical Research Council
Funding Amount
$219,076.00
Summary
In Australia 1 in 25 births are conceived from IVF treatment and this is increasing with the continuing trend towards later childbearing. This study will use linked population data to assess fetal growth and birth defects in IVF-conceived children following major changes to IVF practice in the last decade. There are limited data internationally on health outcomes following the use of more recent IVF techniques and insufficient data to allow for adequate pre-treatment counselling.
Regulation of principal components of the antioxidant system in table grapes. An expanded ?health-claims? system will likely be enacted by Food Standards Australia New Zealand within two years. Horticultural industries are attracted to the promotional ?point of difference? this offers. Many health-promoting compounds are antioxidants, including polyphenols that are abundant in fruit such as grape and citrus. Antioxidants are also involved in the plant's defences against abiotic and biotic stres ....Regulation of principal components of the antioxidant system in table grapes. An expanded ?health-claims? system will likely be enacted by Food Standards Australia New Zealand within two years. Horticultural industries are attracted to the promotional ?point of difference? this offers. Many health-promoting compounds are antioxidants, including polyphenols that are abundant in fruit such as grape and citrus. Antioxidants are also involved in the plant's defences against abiotic and biotic stress. Here, the WA Table Grape industry has committed funds for an APAI to study regulation of antioxidants in relation to nutritional and postharvest qualities. Effects of preconditioning with mild oxidative stresses will be assayed, postharvest, using molecular and biochemical techniques.Read moreRead less
Alpha-2-Macroglobulin And The Transport And Uptake Of The Hormone, Hepcidin
Funder
National Health and Medical Research Council
Funding Amount
$533,541.00
Summary
Hepcidin is a peptide hormone that is a major regulator of iron metabolism. It has been suggested that hepcidin is free in the blood. However, we recently identified that hepcidin binds with alpha-2-macroglobulin (a2-M) in the plasma and this increases the efficacy of this peptide. The demonstration that a2-M plays a role in hepcidin biology will lead to a better understanding of hepcidin physiology, the development of methods for its measurement and improved treatment of iron related diseases.
Regulation Of Neural Progenitor Cell Self-renewal By The RNA-binding Protein ZFP36L1 During Development And Disease
Funder
National Health and Medical Research Council
Funding Amount
$345,401.00
Summary
The timely differentiation of neural stem cells is critical during development, and the unrestrained proliferation of neural stem cells in the adult can lead to deadly brain cancers such as glioma. At present our understanding of the key molecules that regulate neural stem cell behaviour during these processes remains limited. In this proposal we will investigate the molecular determinants underpinning neural stem cell biology, both within the developing brain, and within glioma.
Influence of high temperature on phenology, metabolism and the fate of axillary buds and inflorescences in grapevine. Subtropical regions in Australia, due to a warm climate, land and water availability, have the potential to produce a variety of agricultural produce, particularly fruit, to meet market demand. However adoption of fruit crops, many of which, including table grape, have temperate origins, requires intensive management. Despite years of agronomic R&D, production remains variable du ....Influence of high temperature on phenology, metabolism and the fate of axillary buds and inflorescences in grapevine. Subtropical regions in Australia, due to a warm climate, land and water availability, have the potential to produce a variety of agricultural produce, particularly fruit, to meet market demand. However adoption of fruit crops, many of which, including table grape, have temperate origins, requires intensive management. Despite years of agronomic R&D, production remains variable due to a lack of fundamental knowledge on how climate impacts on the development cycle, particularly flowering, required to produce fruit. This proposal will carry out basic research to provide knowledge that will enable consistent production and expansion of table grape and other temperate crop industries.Read moreRead less
New biotech methods for crop quality assurance. Quality assurance of crop products is a key for Australia to be competitive in the world marketplace. The power of molecular diagnostics has not been applied to this important but neglected part of the produce handling chain. In this project research will be undertaken that will lead to low cost on site assays to test for variety preservation, contamination, and presence of pests and diseases. It employs the tools of genomics and proteomics to p ....New biotech methods for crop quality assurance. Quality assurance of crop products is a key for Australia to be competitive in the world marketplace. The power of molecular diagnostics has not been applied to this important but neglected part of the produce handling chain. In this project research will be undertaken that will lead to low cost on site assays to test for variety preservation, contamination, and presence of pests and diseases. It employs the tools of genomics and proteomics to provide basic understanding of processes which can be developed into cost effective analyses for practical use by industry to ensure quality assurance.Read moreRead less
Enhancing Peripheral Clearance Of Beta Amyloid As A Treatment For Alzheimers Disease
Funder
National Health and Medical Research Council
Funding Amount
$548,681.00
Summary
Amyloid-beta (abeta) accumulation in the brain is a key step in the development of Alzheimer's disease, with potential therapies focusing on its clearance. Compounds that bind abeta in blood have been shown to alter brain abeta levels. We will assess the efficacy of a novel abeta-binding peptide to promote peripheral clearance of brain-derived abeta in a mouse model of AD. Such a drug would be effective in sporadic AD, where the efflux transport, clearance and degradation systems are defective.
Invesitgation of environmental staining and storage discolouration in Faba Bean. Faba beans are an important pulse crop in Australia. They are exported to the Middle East and Europe for human consumption where buff coloured beans are desired. A third of beans become discoloured in storage. These are downgraded to stock feed with a loss of $50 per ton to the grower. Currently little is known about the causes. Environmental factors and selected genotypes will be assessed to determine the potential ....Invesitgation of environmental staining and storage discolouration in Faba Bean. Faba beans are an important pulse crop in Australia. They are exported to the Middle East and Europe for human consumption where buff coloured beans are desired. A third of beans become discoloured in storage. These are downgraded to stock feed with a loss of $50 per ton to the grower. Currently little is known about the causes. Environmental factors and selected genotypes will be assessed to determine the potential causes of discoluration. Analytical techniques will ascertain the discolouration process and the compounds produced. The aim is to provide growers with information on management strategies and breeders of strain resistant genotypes.Read moreRead less