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The Development Of Innovative Multiplexed Molecular Imaging Technology Targeting Improved Diagnostic Imaging Of Glioblastoma Multiforme
Funder
National Health and Medical Research Council
Funding Amount
$403,599.00
Summary
Glioblastoma Multiforme (GBM) is extremely invasive and the most lethal of all primary brain tumours. To optimise treatment planning, we propose to develop novel Multiplexed Molecular Imaging (MMI) technology employing the latest PET-MRI hybrid imaging technology. Our strategy targets the development of new F19 MRI MI agents for measuring tumour infiltration that can be multiplexed with F18 PET hypoxia tracers. Our MI agents can also act as conjugative vehicles for drug delivery.
Improving The Assessment Of Brain Tumour Treatment Outcome Using 18F-FDOPA PET-MRI Fusion
Funder
National Health and Medical Research Council
Funding Amount
$660,666.00
Summary
The mortality rate within the first year of diagnosis for high-grade brain tumours is approximately 80%. A major factor contributing to poor outcome measures is the limitation of current neuroimaging techniques. In a novel approach we propose to combine the information available from MRI and PET images to better define the extent of the tumour and provide markers of early treatment response. This improved diagnostic information should improve survival rates.
Towards The Clinical Application Of Phase-contrast Computed Tomography In Breast Cancer Imaging
Funder
National Health and Medical Research Council
Funding Amount
$687,659.00
Summary
Imaging used for breast cancer screening misses between 15-40% of cancers and uses radiation and painful patient compression. We introduce phase contrast computed tomography, which for the first time clinically since 1895, will exploit X-ray refraction rather than X-ray absorption. Our pilot data demonstrated an increased image signal, offering significantly improved cancer detection, reduced radiation dose and lower tissue compression. This work will include the world-first patient trial.
Structural And Functional Imaging In Paediatric Lung Disease
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Lung imaging is an important part of the clinical care of young patients with respiratory disease. However, the most used method at the moment is computed tomography (CT), which exposes the patient to radiation. One potential radiation-free alternative to CT is lung magnetic resonance imaging (MRI). This project will investigate how well lung MRI performs clinically in two important childhood diseases: cystic fibrosis, and preterm birth.
Policy Translation Of An Australian Evaluation Of Computed Tomography (CT) Scanning
Funder
National Health and Medical Research Council
Funding Amount
$398,295.00
Summary
Our study will inform the national health care policy debate with respect to the future role of CT scanning in the health system, and provide the information needed to launch the dialogue among expert clinicians and technicians necessary for practitioner consensus in the appropriate methods for use of CT scanning. This study will use routinely collected administrative health data and data collected from CT scan providers in WA to evaluate the use of CT scanning in the Australian health system.