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Developing New Therapeutic Targets And Identifying Biomarkers For Gestational Diabetes And Ovarian Cancer Using Extracellular Vesicles
Funder
National Health and Medical Research Council
Funding Amount
$1,431,623.00
Summary
Gestational diabetes mellitus (GDM) is the fastest growing type of diabetes in Australia. Ovarian cancer (OVCA) is the most lethal gynaecological cancer, and an effective early diagnosis is critical with potential to improve patient survival. I expect to identify novel mechanisms associated with circulating extracellular vesicles (i.e. nanovesicles released from all living cells), and decipher their role in regulating maternal insulin sensitivity, and their association with OVCA progression.
Reducing The Burden Of Breast Cancer Through Precision Prevention, Targeted Treatment And Enhanced Survivorship
Funder
National Health and Medical Research Council
Funding Amount
$1,491,192.00
Summary
Breast cancer affects 1 in 8 Australian women. Of all the cancers, breast cancer results in the largest number of years of healthy life lost from death and illness. My research will reduce this unacceptable burden of breast cancer for women and their families. Spanning prevention, through treatment to survivorship, it will facilitate reduced breast cancer incidence, more effective treatments and enhanced understanding of the effects of new treatments on ovarian function and fertility.
Mapping Neurodevelopmental Disorders In A Zebrafish Model
Funder
National Health and Medical Research Council
Funding Amount
$2,760,520.00
Summary
The way in which the brain develops differently in neurodevelopmental disorders such as autism is hard to reveal in humans, but can be addressed in a zebrafish model. Using cutting-edge imaging and computational techniques, this project will investigate how neural representations of the world develop differently between normal zebrafish and zebrafish mutant for a gene that causes autism. This will provide new insights into the mechanisms of altered circuit development in autism.