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Cellular Plasticity in the Brain: discovering molecular mechanisms controlling the production of neurons during brain development, function, ageing and disease. The program aims to understand the mechanisms regulating Brain Plasticity - this recently discovered property of the brain to respond to environmental stimuli, both physiological and pathological, by producing new functional neurons. Specifically, the program will discover how the brain's stem cells are stimulated to produce new neurons. ....Cellular Plasticity in the Brain: discovering molecular mechanisms controlling the production of neurons during brain development, function, ageing and disease. The program aims to understand the mechanisms regulating Brain Plasticity - this recently discovered property of the brain to respond to environmental stimuli, both physiological and pathological, by producing new functional neurons. Specifically, the program will discover how the brain's stem cells are stimulated to produce new neurons. This understanding will significantly expand our knowledge of how the brain develops, and how functions, like memory, are modulated by neuronal replacement. Discoveries will underpin the development of, in association with Australia's biotechnology sector, a new generation of therapeutics, which treat neurological diseases, like Stroke, by stimulating the production of functional neurons.Read moreRead less
Assessing gene function in the developing brain using zebrafish as a model system. As the average life expectancy in western countries rises there is an increasing incidence of mental health problems. Therapeutic approaches to both Alzhemier's and Parkinson's disease, as well as to brain injury following stroke, rely on a thorough understanding of how the brain develops. This is consistent with the everyday principle that if you want to fix something that is broken, then you need to understand h ....Assessing gene function in the developing brain using zebrafish as a model system. As the average life expectancy in western countries rises there is an increasing incidence of mental health problems. Therapeutic approaches to both Alzhemier's and Parkinson's disease, as well as to brain injury following stroke, rely on a thorough understanding of how the brain develops. This is consistent with the everyday principle that if you want to fix something that is broken, then you need to understand how it is put together in the first place. This project seeks to understand how the normal brain is wired together in the embryo and, in doing so it will expose novel targets for therapy in the aged.Read moreRead less