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Investigate The Role For Dok Adapter Proteins In Thrombosis And Haemostasis.
Funder
National Health and Medical Research Council
Funding Amount
$161,737.00
Summary
Blood platelets play a key role in blood clot formation, prevention of bleeding and are the principal elements contributing to thrombosis leading to heart attack and stroke. Numerous studies have defined pathways promoting platelet activity, however less is known about their negative regulation. In this fellowship I will examine the role for proteins, Dok2 and Dok1, in the negative regulation of platelets, hoping this leads to development of novel therapeutics for prevention of cardiac disease.
New Insights Into The Mechanisms Of Thrombogenesis In Atrial Fibrillation
Funder
National Health and Medical Research Council
Funding Amount
$443,946.00
Summary
Atrial fibrillation (AF) is the most common heart rhythm disturbance (arrhythmia), which is associated with a high risk of stroke due to clot formation within the left atria. At present we still only have a limited understanding of the mechanism of clot formation in AF. The aim of this study is to determine the critical mechanisms that contribute to clot formation within the left atria in AF. This knowledge is fundamental to the development of more successful interventional approaches.
Elucidating The Mechanism And Function Of Cell Disassembly During Apoptosis
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
In humans, billions of cells will die daily in various organs as part of normal turnover and disease progression. During cell death, dying cells can disassembly in to smaller fragments, a process that could facilitate their removal, as well as mediate communication with other healthy cells. I aim to understand the machinery that control how dying cells can disassemble into smaller pieces and their function in influenza A infection.
The Molecular Determinants Of Immunological Tolerance
Funder
National Health and Medical Research Council
Funding Amount
$473,477.00
Summary
Autoimmune diseases, such as type I diabetes and multiple sclerosis, are debilitating disorders that impose a massive toll on wellbeing in Australia and worldwide. This fellowship will support research aimed at determining the genes and mechanisms that control autoimmunity. New technologies will be brought to bear to track immune cells throughout their development, maturity and malfunction in disease settings. We aim to uncover new therapeutic targets to prevent and reverse autoimmune disease.
Female fertility and age at menopause are determined by the number and quality of eggs stored in the ovaries. For unknown reasons, two-thirds of all eggs die soon after they are made. Furthermore, a serious side effect of cancer treatment is egg death resulting in infertility and early menopause. I am unravelling the genes involved in determining whether an egg will live or die. This understanding will help us develop novel strategies to preserve fertility during aging and cancer treatment.
Schistosomiasis is a disease caused by parasites known as schistosomes. As the current use of a single drug could lead to resistance, there is an urgency for new drugs. I discovered a novel cell death machinery in schistosomes and I now aim to unravel how this cell death pathway works and to identify the players required for parasite survival. The next step will then be to develop molecules that neutralize the activity of these pro-survival molecules hence leading to parasite death.