Folding and dynamics of bioengineered cyclic cystine knot proteins. This project will increase knowledge of the structure and function of an important family of proteins, namely the conotoxins. Conotoxins are of particular interest in Australia as nearly 300 species of cone snails occur in Australian waters and they represent a rich source of novel peptides for drug discovery. This project will enhance their stability by altering their structures and will have a direct impact on peptide-drug ba ....Folding and dynamics of bioengineered cyclic cystine knot proteins. This project will increase knowledge of the structure and function of an important family of proteins, namely the conotoxins. Conotoxins are of particular interest in Australia as nearly 300 species of cone snails occur in Australian waters and they represent a rich source of novel peptides for drug discovery. This project will enhance their stability by altering their structures and will have a direct impact on peptide-drug based therapies, resulting in economic and social benefits for Australian society. Additionally, some peptides under study have agricultural significance for crop protection and this too, has the potential to provide significant economic benefits. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453637
Funder
Australian Research Council
Funding Amount
$256,804.00
Summary
Multi-dimensional polymer characterization facility. The microstructure of polymers dominates their physical properties. This integrated facility will create a world-leading means of characterizing in multiple dimensions the microstructure of complex polymers, eg copolymers and branched polymers. The facility will yield information on the distributions of chain end-groups, monomer microstructure, and branches, as functions of molecular weight. The facility will provide otherwise unobtainable dat ....Multi-dimensional polymer characterization facility. The microstructure of polymers dominates their physical properties. This integrated facility will create a world-leading means of characterizing in multiple dimensions the microstructure of complex polymers, eg copolymers and branched polymers. The facility will yield information on the distributions of chain end-groups, monomer microstructure, and branches, as functions of molecular weight. The facility will provide otherwise unobtainable data for a set of projects exploring questions ranging from how new synthetic materials with tailor-made properties can be created, through to how our understanding of natural polymers can be advanced to improve crop utilization.Read moreRead less