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Predicting Intrapartum Fetal Compromise At Term Using The Fetal Cerebro-umbilical Ratio And Placental Growth Factor Levels
Funder
National Health and Medical Research Council
Funding Amount
$86,733.00
Summary
A lack of oxygen to a baby after the onset of labour (i.e. fetal distress) in an otherwise healthy pregnancy is one of the top three causes of death in singleton pregnancies after 37 weeks. Our previous research has shown that a late pregnancy ultrasound scan combined with a blood test from the mother measuring the levels of a placental hormone can potentially identify pregnancies at risk. We aim to assess the value of this screening test at a major tertiary hospital.
The Cardiovascular Toll Of Pre-eclampsia: Determining Impacts On The Maternal, Fetal And Placental Vasculature.
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Pre-eclampsia is a common condition of pregnancy that causes a rise in blood pressure, protein in the urine and damage to other organs. It can cause significant harm to the mother and baby. In the long term, mums who have had pre-eclampsia are at a higher risk of developing heart problems. We want to explore how the heart changes in a pregnancy complicated by pre-eclampsia, and see if these changes can help us predict pregnancy risk and long term outcomes.
Blood Pressure Effects On Placental Growth And Development
Funder
National Health and Medical Research Council
Funding Amount
$133,357.00
Summary
Diseases causing high blood pressure in pregnancy or preeclampsia are a major cause of complications in mother and infant. At present, the only treatment is delivery of the baby who may be premature or too small. Why preeclampsia develops is incompletely understood and the long term consequences of this disease for the mother includes doubling of the future risk of heart and kidney disease. This research will look at the placenta or afterbirth at a molecular level to better understand why this d ....Diseases causing high blood pressure in pregnancy or preeclampsia are a major cause of complications in mother and infant. At present, the only treatment is delivery of the baby who may be premature or too small. Why preeclampsia develops is incompletely understood and the long term consequences of this disease for the mother includes doubling of the future risk of heart and kidney disease. This research will look at the placenta or afterbirth at a molecular level to better understand why this disease occurs.Read moreRead less
Falling Insulin Requirements Study (FIRST) In Diabetic Pregnancy
Funder
National Health and Medical Research Council
Funding Amount
$107,764.00
Summary
Falling insulin requirements in late pregnancy is thought to signify abnormal placental function and increased risk to mother and baby in diabetic pregnancies. As there is currently limited evidence in the literature, the proposed study aims to examine placental dysfunction in this group of women through monitoring adverse outcomes, serial ultrasound measurements, blood biomarkers and histopathology examination. The results will help direct appropriate clinical care to improve outcomes and predi ....Falling insulin requirements in late pregnancy is thought to signify abnormal placental function and increased risk to mother and baby in diabetic pregnancies. As there is currently limited evidence in the literature, the proposed study aims to examine placental dysfunction in this group of women through monitoring adverse outcomes, serial ultrasound measurements, blood biomarkers and histopathology examination. The results will help direct appropriate clinical care to improve outcomes and predict those at highest risk.Read moreRead less
Maternal Gut Microbiome During Pregnancy Influences Offspring Atopy And Asthma.
Funder
National Health and Medical Research Council
Funding Amount
$46,622.00
Summary
Allergic diseases such as food allergy and asthma have increased significantly as our exposure to bacteria has reduced. Many studies have explored exposure to bacteria in early life but few have examined the maternal bacteria we are exposed to while we develop in the womb. New studies indicate that we are exposed to many different components of our mothers gut bacteria and this might change our developing immune system and determine whether or not we get diseases like food allergy and asthma.
In Vivo Studies On Ventriculo-vascular Coupling And The Role Of Aortic Pressure Wave Morphology On Coronary Blood Flow
Funder
National Health and Medical Research Council
Funding Amount
$137,700.00
Summary
Heart disease is a leading cause of death and disability in Australia. Conditions resulting in reduced blood flow to the heart are particularly common and dangerous. Despite significant progress, we still do not understand exactly how changes in heart function and the aorta (the major artery arising from the heart) affect blood flow to the heart. This study will utilise sophisticated new techniques to look at the interactions between heart function, pressure in the aorta and coronary blood flow
Reference Values For Spirometry, Lung Volumes, Diffusing Capacity, And Fractional Exhaled Nitric Oxide In First Nations Australians
Funder
National Health and Medical Research Council
Funding Amount
$83,832.00
Summary
Reference values in lung function tests allow respiratory doctors to accurately interpret results in order to effectively diagnose, treat and manage respiratory disease. Currently, reference values do not exist for First Nations adults. I will recruit 600 healthy First Nations adults from communities in Queensland and the Northern Territory for several lung function tests. Data collected will be submitted to the Global Lung Function Initiative to be incorporated into future guidelines.
Effects Of Replacement And Withdrawal Of Testosterone In Human Males On Muscle, Bone And Fat
Funder
National Health and Medical Research Council
Funding Amount
$156,682.00
Summary
Male sex hormone or androgen deficiency (AD) is a common, but under-diagnosed condition. AD decreases well being and contributes to muscle weakness, bone fragility and weight gain. Cutting edge technology will be used to help explain how AD may relate to these negative effects, particularly on muscle function. Given the importance of aging, frailty, osteoporosis and obesity, understanding the role of hormones in these conditions may have major implications for prevention and treatment.
Cognitive And Psychosocial Functioning In Patients With Idiopathic Generalized Epilepsies
Funder
National Health and Medical Research Council
Funding Amount
$123,143.00
Summary
Children born extremely preterm are at risk of struggling at school and falling behind normal educational milestones, and having emotional problems such as anxiety. This study aims to see whether anxiety affects these children’s ability to learn and use new information. It will also determine whether an intervention targeting these thinking skills is less useful in children with higher levels of anxiety.