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Functional Analysis Of A Novel Genetic Mouse Model For Congenital Growth Hormone Deficiency
Funder
National Health and Medical Research Council
Funding Amount
$519,131.00
Summary
Pituitary Hormone deficiency is not uncommon and is associated with poor growth, metabolism and fertility. Some cases of this disorder arise due to genetic changes that compromise the ability of the pituitary gland to make or secrete growth hormone (GH). Using cutting-edge genomics technology, we have generated a new genetic mouse model of GH deficiency. The aim of this project is to understand the function of this novel GH _regulating gene in mice and in humans.
Regulation Of Growth Hormone Profile By Metabolic Balance: Neuronal, Neuroendocrinal And Molecular Mechanism
Funder
National Health and Medical Research Council
Funding Amount
$413,257.00
Summary
Obesity is associated with a reduction in growth hormone secretion. As growth hormone maintains muscle mass at the expense of fat this may further promote the obese condition. This project will determine the physiological role of ghrelin, a hormone that signals hunger, in maintaining growth hormone secretion under normal, fasting and obese conditions. Clarification of the role of ghrelin in regulating growth hormone secretion may aid in the development of pharmacological agents to assist and mai ....Obesity is associated with a reduction in growth hormone secretion. As growth hormone maintains muscle mass at the expense of fat this may further promote the obese condition. This project will determine the physiological role of ghrelin, a hormone that signals hunger, in maintaining growth hormone secretion under normal, fasting and obese conditions. Clarification of the role of ghrelin in regulating growth hormone secretion may aid in the development of pharmacological agents to assist and maintain weight loss.Read moreRead less
This project is about the way that the brain controls reproduction. It is important because there is no known cause for infertility in a significant number people with such a problem. The project should inform us on new ways to manage particular forms of reproductive failure.
Gonadotropin Inhibitory Hormone (GnIH); A Negative Regulator Of Reproduction
Funder
National Health and Medical Research Council
Funding Amount
$752,936.00
Summary
Gonadotropin inhibitory hormone (GnIH) is a short peptide of 8 amino acids that is produced by the brain and acts in a negative manner on brain and pituitary cells that control reproduction. This project aims to elucidate the role of GnIH in normal physiology and in states of stress and negative metabolic state. Work will be carried out in various species to define the function of the peptide and also to investigate ways that it can be utilised to prevent reproduction.
Elucidating The In Vivo Role Of The Pro-survival Gene Mcl-1 In Mammary Gland Development And Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$664,691.00
Summary
Breast cancer strikes one in 8 women by age 85 and is a major cause of morbidity and mortality. Despite recent improvements, the immense breast cancer burden demands new strategies that will radically improve patient outcomes. This project will address a hallmark of cancer: evasion of apoptosis. Understanding the molecular events that promote tumour survival and resistance to therapy represents a key area in cancer biology that has yet to be properly applied to breast cancer.
THE EFFECT OF STRESS AND ENVIRONMENTAL ENRICHMENT ON DISEASE PROGRESSION IN MESIAL TEMPORAL LOBE EPILEPSY
Funder
National Health and Medical Research Council
Funding Amount
$578,201.00
Summary
Mesial temporal lobe epilepsy, the most common form of drug-resistant epilepsy in adults, is a progressive neurodegenerative condition for which there is currently no effective disease modifying treatment. This proposal will explore whether co-morbid stress accelerates disease progression in MTLE, and whether targeting stress pathways by medical and environmental manipulations can mitigate against this.
The Role Of Interleukin (IL)-27 In The Endogenous Anti-tumour Immune Response And The Use Of An IL-27 Agonist As A Cancer Therapeutic.
Funder
National Health and Medical Research Council
Funding Amount
$473,960.00
Summary
Our data in mice suggest that immune cell signalling protein, interleukin (IL)-27, enhances anti-tumour immune responses and slows growth of mammary tumours and carcinogen induced sarcomas. This project aims to test how IL-27 promotes protective anti-tumour immune responses and to develop a modified IL-27 protein that will be tested as a cancer therapeutic in mice. This will be the first study to examine IL-27 function using physiological tumour models and may provide proof of concept for a new ....Our data in mice suggest that immune cell signalling protein, interleukin (IL)-27, enhances anti-tumour immune responses and slows growth of mammary tumours and carcinogen induced sarcomas. This project aims to test how IL-27 promotes protective anti-tumour immune responses and to develop a modified IL-27 protein that will be tested as a cancer therapeutic in mice. This will be the first study to examine IL-27 function using physiological tumour models and may provide proof of concept for a new therapeutic strategy for some human cancers.Read moreRead less
PACAP: The Mechanism Underlying Sleep Apnoea-induced Hypertension
Funder
National Health and Medical Research Council
Funding Amount
$505,117.00
Summary
10% of Australians suffer from sleep apnoea; a cause of high blood pressure. Untreated, high blood pressure causes heart failure, kidney failure and stroke. A major cause of high blood pressure is an increased amount of nerve activity that controls the heart and blood vessels. In this proposal we will investigate how a brain chemical, called PACAP, affects nerve activity and blood pressure in a model of sleep apnoea. This information may lead to new and better treatments for high blood pressure.
Investigating A Novel Agent To Limit Brain Injury And Post-stroke Complications
Funder
National Health and Medical Research Council
Funding Amount
$412,429.00
Summary
Stroke is a leading cause of morbidity and mortality worldwide, but treatment options remain limited. The goal of this research project will be to examine the potential of new agent to protect the brain against stroke and to also treat complications that typically occur after stroke including infection and weight loss. It is anticipated that this project will ultimately lead to the development of an effective stroke therapy.