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Inhibition Of IFN-?/? By Human Metapneumovirus And The Induction Of Inflammation
Funder
National Health and Medical Research Council
Funding Amount
$605,251.00
Summary
The newly isolated human metapneumovirus (hMPV) causes significant respiratory illness in infants, young children and the elderly. The virus can persist long-term and may predispose individuals to chronic lung disease. This proposal aims to determine the mechanisms by which hMPV infection causes respiratory disease, with a view to improving treatments and preventing disease.
The role of muscle and tendon mechanics in human muscle damage. This project aims to examine what sort of forceful stretch is required to cause exercise induced muscle damage (EIMD) in humans and how muscles adapt to limit future damage. Specifically, the project aims to examine how the elastic properties of tendons might reduce muscle damage by buffering stretch in muscle fibres. Using cutting-edge ultrasound imaging technology, human muscle strain in different regions of muscle will be examine ....The role of muscle and tendon mechanics in human muscle damage. This project aims to examine what sort of forceful stretch is required to cause exercise induced muscle damage (EIMD) in humans and how muscles adapt to limit future damage. Specifically, the project aims to examine how the elastic properties of tendons might reduce muscle damage by buffering stretch in muscle fibres. Using cutting-edge ultrasound imaging technology, human muscle strain in different regions of muscle will be examined to quantify the temporal relationship between muscle power absorption and EIMD. The importance of muscle and tendon mechanical properties in buffering the muscle from potential damage will be gauged. This could be a critical mechanism for preventing EIMD in exercising humans.Read moreRead less
Top-down rehydration: role of multiple water sources in mangrove function. This project aims to combine cutting-edge analytical and imaging techniques to assess contributions of atmospheric water sources to shoot-water balances, identify leaf traits associated with top-down rehydration, and determine the relative importance of different sources of water used by mangroves in maintenance of photosynthetic carbon assimilation along natural gradients in salinity and aridity. The capacity of shoots ....Top-down rehydration: role of multiple water sources in mangrove function. This project aims to combine cutting-edge analytical and imaging techniques to assess contributions of atmospheric water sources to shoot-water balances, identify leaf traits associated with top-down rehydration, and determine the relative importance of different sources of water used by mangroves in maintenance of photosynthetic carbon assimilation along natural gradients in salinity and aridity. The capacity of shoots to absorb atmospheric water could profoundly affect the diversity, survival and productivity of mangroves where high soil salinity limits water uptake by roots, particularly during hot, dry conditions.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100206
Funder
Australian Research Council
Funding Amount
$550,000.00
Summary
Lattice light sheet microscopy for imaging biology in real space and time. This project aims to establish a Lattice Light-Sheet Microscope (LLSM) Facility, to provide the dedicated computing infrastructure needed for terabyte-scale image acquisition and handling. Lattice light sheet microscopy allows four-dimensional imaging of live biological specimens from individual molecules to small organisms. The microscope images live specimens without phototoxicity or photobleaching, enabling prolonged i ....Lattice light sheet microscopy for imaging biology in real space and time. This project aims to establish a Lattice Light-Sheet Microscope (LLSM) Facility, to provide the dedicated computing infrastructure needed for terabyte-scale image acquisition and handling. Lattice light sheet microscopy allows four-dimensional imaging of live biological specimens from individual molecules to small organisms. The microscope images live specimens without phototoxicity or photobleaching, enabling prolonged imaging of significant physiological or biophysical events. Expected outcomes include high impact discoveries and publications in fundamental research, rapid solutions for industry-focussed projects and opportunities for collaboration, research and development. The imaging is expected to reveal key scientific insights and showcase biology to the public.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100190
Funder
Australian Research Council
Funding Amount
$620,000.00
Summary
Electrophysiology Platform for Ion-channel Characterisation. Ion channels are ubiquitous pore-forming membrane proteins, with the human genome encoding >300 ion channels. The diverse roles of ion channels include action potential generation, control of ion flow across secretory and epithelial cells, and regulation of cell volume, motility and proliferation. Pharmacological modulators are powerful tools for probing ion channel function, but for most channels these tools are lacking. Thus, this p .... Electrophysiology Platform for Ion-channel Characterisation. Ion channels are ubiquitous pore-forming membrane proteins, with the human genome encoding >300 ion channels. The diverse roles of ion channels include action potential generation, control of ion flow across secretory and epithelial cells, and regulation of cell volume, motility and proliferation. Pharmacological modulators are powerful tools for probing ion channel function, but for most channels these tools are lacking. Thus, this project aims to develop the first comprehensive toolbox of ion channel modulators using an integrated in vitro/in vivo electrophysiology platform. These pharmacological tools will be made freely available to the Australian research community for probing the mechanism and physiological function of ion channels.Read moreRead less
Photosynthetic traits as “key performance indicators” of coral health. The objective of this project is to advance knowledge on the healthy functioning of the coral–algal symbiosis, which defines the response of coral reef ecosystems to worldwide environmental change. Current approaches to address this problem have linked coral health to algal symbiont diversity but have been unable to resolve the fundamental symbiont functional traits that govern this link – the “key performance indicators (KPI ....Photosynthetic traits as “key performance indicators” of coral health. The objective of this project is to advance knowledge on the healthy functioning of the coral–algal symbiosis, which defines the response of coral reef ecosystems to worldwide environmental change. Current approaches to address this problem have linked coral health to algal symbiont diversity but have been unable to resolve the fundamental symbiont functional traits that govern this link – the “key performance indicators (KPIs)”. This project plans to couple advanced physiological and functional genomics techniques to transform our understanding of how algal symbiont metabolic KPIs regulate coral growth and stress susceptibility. This may provide new diagnostic capability for the assessment of coral health and may enable us to improve coral reef ecosystem management.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102948
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Interactive computer vision for image interpretation. This project aims at pushing forward the fundamental research in interactive computer vision. The outcome of this project will enable reliable and efficient solutions to real world image interpretation tasks, such as medical image analysis, financial document processing, and impact evaluation from natural disasters.
Discovery Early Career Researcher Award - Grant ID: DE170100319
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Fast three-dimensional imaging of neural signal propagation using light-field microscopy. This project aims to use a light-field microscope to reveal the dynamics of sustained neural activity in the brain. The brain’s neurons are highly interconnected, so neural signals can be sustained in a repeating cycle. While this may underlie tasks such as working memory, its role in information processing is unclear. Understanding information processing is vital for finding treatments for neurodegenerativ ....Fast three-dimensional imaging of neural signal propagation using light-field microscopy. This project aims to use a light-field microscope to reveal the dynamics of sustained neural activity in the brain. The brain’s neurons are highly interconnected, so neural signals can be sustained in a repeating cycle. While this may underlie tasks such as working memory, its role in information processing is unclear. Understanding information processing is vital for finding treatments for neurodegenerative disorders. To characterise this large-scale aspect of neural computation, this project measures neural activity at high speed across large numbers of neurons. This is expected to provide evidence of the nature of sustained activity which may in the future lead to treatments for neurodegenerative disorders.Read moreRead less
Hydraulic control on water use, growth and survival in tropical rainforest. This project aims to measure drought-related limits to water transport in the woody xylem tissue of trees in Australian tropical rainforests, to understand how this influences tree water use, photosynthesis, health and mortality risk. Tropical rainforests are sensitive to climate variability, especially drought, but this sensitivity is poorly understood, despite large effects regionally and globally. This project will co ....Hydraulic control on water use, growth and survival in tropical rainforest. This project aims to measure drought-related limits to water transport in the woody xylem tissue of trees in Australian tropical rainforests, to understand how this influences tree water use, photosynthesis, health and mortality risk. Tropical rainforests are sensitive to climate variability, especially drought, but this sensitivity is poorly understood, despite large effects regionally and globally. This project will compare forests that contrast strongly in seasonal drought stress, and use the information to develop a model designed for species-diverse forest, with subsequent potential global application. The understanding gained will enable widely applicable advances designed to feed through rapidly to regional- and global-scale models that inform land use, economic and social policy-making.Read moreRead less
Non-equilibrium material phases. This project aims to synthesise and characterise exotic materials produced in the laboratory under conditions that replicate those inside planets and stars. Highly non-equilibrium processing methods are needed to find entirely new material forms of elements and compounds created under extreme pressure and temperature. The project will use its laser-based synthesis method to explore and understand the non-equilibrium pathways and develop new materials. Understandi ....Non-equilibrium material phases. This project aims to synthesise and characterise exotic materials produced in the laboratory under conditions that replicate those inside planets and stars. Highly non-equilibrium processing methods are needed to find entirely new material forms of elements and compounds created under extreme pressure and temperature. The project will use its laser-based synthesis method to explore and understand the non-equilibrium pathways and develop new materials. Understanding how these materials form could lead to the next materials revolution. This research will lead to materials that industry sectors can exploit for commercial benefits.Read moreRead less