Brain development during adolescence and the emergence of depression: A longitudinal MRI study. Traditionally mental health services have focused on established disorders. Whilst significant gains in outcomes have been obtained in other areas of health by focusing on early intervention and prevention, in the mental health field this approach has been limited by the inability to predict who is likely to go on to develop serious mental disorder. This study will provide critical information for und ....Brain development during adolescence and the emergence of depression: A longitudinal MRI study. Traditionally mental health services have focused on established disorders. Whilst significant gains in outcomes have been obtained in other areas of health by focusing on early intervention and prevention, in the mental health field this approach has been limited by the inability to predict who is likely to go on to develop serious mental disorder. This study will provide critical information for understanding the risk processes that are operating during the critical phase of early adolescence, and will therefore make a fundamental contribution to our understanding of who, and what, to target in early intervention and prevention strategies.Read moreRead less
Charting the prevalence, time course and social-cognitive correlates of neonatal imitation. Imitation is something that we do naturally and often. However, because the necessary research has not been done, it remains controversial whether or not humans can imitate from birth and what role this may play for later developments. The proposed research aims to settle these issues through a comprehensive, longitudinal study of infant imitation and its relation to later-developing social skills. A trai ....Charting the prevalence, time course and social-cognitive correlates of neonatal imitation. Imitation is something that we do naturally and often. However, because the necessary research has not been done, it remains controversial whether or not humans can imitate from birth and what role this may play for later developments. The proposed research aims to settle these issues through a comprehensive, longitudinal study of infant imitation and its relation to later-developing social skills. A training condition will examine the viability of potential early interventions aimed at promoting social responding in infants and toddlers. This project will generate new knowledge about the development of early social skills and provide the foundation for new programs to enhance social development in typical and at-risk infants. Read moreRead less
Uncovering the mechanisms of early memory development: A new approach using eye tracking. This research represents a theoretical and methodological advance in developmental science. In combining behavioural measures of infant memory with novel eye-tracking methods and electrophysiology, this research will significantly advance our knowledge about the nature of infant memory representation and our understanding of the mechanisms of early memory development. The research will further solidify Aust ....Uncovering the mechanisms of early memory development: A new approach using eye tracking. This research represents a theoretical and methodological advance in developmental science. In combining behavioural measures of infant memory with novel eye-tracking methods and electrophysiology, this research will significantly advance our knowledge about the nature of infant memory representation and our understanding of the mechanisms of early memory development. The research will further solidify Australia's reputation as an innovative leader in the rapidly growing field of developmental cognitive neuroscience. Third, the interdisciplinary nature of this project will provide internationally-competitive research training opportunities for Australian students.Read moreRead less
Glucose facilitation of cognitive function: Effects of effort, age and glucose control. Age-related decline in mental capacity contributes to the economic (estimated at over 2 trillion AUD by 2050), social and human costs of an increasingly older Australian population. The studies in this program aim to understand the role of poor control of blood glucose in age-related cognitive deficits. The role of individual differences in biological (hormonal responses) and psychological (stress and appetit ....Glucose facilitation of cognitive function: Effects of effort, age and glucose control. Age-related decline in mental capacity contributes to the economic (estimated at over 2 trillion AUD by 2050), social and human costs of an increasingly older Australian population. The studies in this program aim to understand the role of poor control of blood glucose in age-related cognitive deficits. The role of individual differences in biological (hormonal responses) and psychological (stress and appetite) factors will also be assessed. A better understanding of the nature of age-related cognitive decline as it relates to biological processes such as blood glucose control will help to develop tangible strategies to combat age-related cognitive decline and dementia (which has been described as Type 3 diabetes).Read moreRead less
Disgust as a psychosocial defence against infectious disease. Globally, around 1 in 4 deaths result from infectious disease. Humans have evolved two basic means to combat this - an immune system and behaviours to avoid getting sick. This project examines one such behaviour, disgust, and aims to determine its role in disease avoidance. Studying disgust can lead to novel insights into behaviours as diverse as risky sexual decision-making and illness-related stigmatisation (e.g. of people with AID ....Disgust as a psychosocial defence against infectious disease. Globally, around 1 in 4 deaths result from infectious disease. Humans have evolved two basic means to combat this - an immune system and behaviours to avoid getting sick. This project examines one such behaviour, disgust, and aims to determine its role in disease avoidance. Studying disgust can lead to novel insights into behaviours as diverse as risky sexual decision-making and illness-related stigmatisation (e.g. of people with AIDS or cancer). Disgust can also be used to directly improve human health. For example, it can be exploited to boost hand hygiene. If widely applied, this simple measure could annually save an estimated 1.5 million children's lives, reduce rates of flu, colds, food poisoning and hospital acquired infections.Read moreRead less
Maturation of the brain and the development of cognitive abilities. This project aims to develop techniques for measuring the growing brain. We will use these techniques to determine how the growing brain influences a child's intellectual ability and to answer an important question - do areas of the brain mature at the same or different rates and what influence does that have on the development of specific abilities such as language and reasoning? An answer to this question will make an import ....Maturation of the brain and the development of cognitive abilities. This project aims to develop techniques for measuring the growing brain. We will use these techniques to determine how the growing brain influences a child's intellectual ability and to answer an important question - do areas of the brain mature at the same or different rates and what influence does that have on the development of specific abilities such as language and reasoning? An answer to this question will make an important contribution to our theoretical understanding of developmental disorders. Moreover, given the influence of intellectual development on life prospects, it is important to understand how early brain development impacts on a child's ability to learn.Read moreRead less
Cognitive, behavioural and educational outcomes of fetal antiepileptic drug exposure. The study falls within the National Research Priority of Promoting and Maintaining Good Health, in particular the Priority Goal - A Healthy Start to Life. The research will yield information crucial to our understanding of the effects of fetal AED exposure on cognitive and behavioural development in the significant number of affected Australian children born each year. It will enhance the nation's ability to de ....Cognitive, behavioural and educational outcomes of fetal antiepileptic drug exposure. The study falls within the National Research Priority of Promoting and Maintaining Good Health, in particular the Priority Goal - A Healthy Start to Life. The research will yield information crucial to our understanding of the effects of fetal AED exposure on cognitive and behavioural development in the significant number of affected Australian children born each year. It will enhance the nation's ability to develop strategies for prevention, surveillance and remediation of adverse outcomes in early childhood, thus supporting the Government's National Agenda for Early Childhood initiative. As a consequence educational assistance can be targeted for those children likely to experience difficulties. Read moreRead less
Ageing and the allocation of selective attention over time: behavioural, neurophysiological and neuroanatomical correlates. Only by fully understanding cognitive decline that occurs with age can we hope to provide appropriate interventions to slow or arrest the underlying neural degeneration. Part A, the first of three consecutive parts, will use novel paradigms to investigate various aspects of selective attention and cognition. Part B will investigate the regions of the brain underlying the te ....Ageing and the allocation of selective attention over time: behavioural, neurophysiological and neuroanatomical correlates. Only by fully understanding cognitive decline that occurs with age can we hope to provide appropriate interventions to slow or arrest the underlying neural degeneration. Part A, the first of three consecutive parts, will use novel paradigms to investigate various aspects of selective attention and cognition. Part B will investigate the regions of the brain underlying the temporal allocation of selective attention by comparing the performance of patients with focal lesions, and separately by using event-related potential (ERP) technology. Finally, Part C will evaluate the rate and type of cognitive decline with age using a range of reaction time-independent tasksRead moreRead less
The role of preferred brain states in perceptual and cognitive processing: New insights into brain dynamics. New insights into brain dynamics will improve our understanding of both normal and atypical functioning. Extending previous work on normals will confirm how innovative Australian approaches can lead the research agenda in basic neuroscience, at the psychology-physiology interface. Testing in AD/HD and elderly populations will clarify dysfunctional brain mechanisms underlying AD/HD, and th ....The role of preferred brain states in perceptual and cognitive processing: New insights into brain dynamics. New insights into brain dynamics will improve our understanding of both normal and atypical functioning. Extending previous work on normals will confirm how innovative Australian approaches can lead the research agenda in basic neuroscience, at the psychology-physiology interface. Testing in AD/HD and elderly populations will clarify dysfunctional brain mechanisms underlying AD/HD, and the cognitive losses in elderly populations (exacerbated by dementia). These results may lead to better diagnosis, treatment, and community understanding of these groups. Also, publications on these target groups will demonstrate internationally the widespread utility of this approach, encouraging further novel applications of basic neuroscience in health.Read moreRead less
Testing a disease avoidance account of disgust. Inadequate hand-washing is responsible for some of the yearly 2 million deaths from diarrhoea (WHO), for an estimated 40% of the 80 million cases of foodborne illness in the US (CDC) and for approximately 20% of the 20,000 US deaths from hospital acquired infections (CDC). Although the value of hand-washing as a disease avoidance strategy is well understood by many, even healthcare professionals do not follow hand-washing guidelines. This project ....Testing a disease avoidance account of disgust. Inadequate hand-washing is responsible for some of the yearly 2 million deaths from diarrhoea (WHO), for an estimated 40% of the 80 million cases of foodborne illness in the US (CDC) and for approximately 20% of the 20,000 US deaths from hospital acquired infections (CDC). Although the value of hand-washing as a disease avoidance strategy is well understood by many, even healthcare professionals do not follow hand-washing guidelines. This project examines why the emotion of disgust engenders such potent avoidance of certain disease vectors (e.g. faeces). The project should lead to an understanding of how we can get inadequate hand-washing to also evoke disgust and thus to new and powerful strategies to improve hand-washing compliance.Read moreRead less