Improving Outcomes And Cost Of Systemic Sclerosis Related Pulmonary Arterial Hypertension
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
My research program aims to improve the outcomes for those living with systemic sclerosis related pulmonary arterial hypertension (SSc-PAH) and reduce its associated societal burden through the evaluation and implementation of a novel PAH screening algorithm; the use of risk stratification tools in therapeutic decisions; and the development of a more streamlined management approach. My research will initiate collaboration across multiple medical disciplines and sites nationally.
Environmental and physiological drivers of immune function in frogs. This project aims to investigate how ultraviolet B radiation and temperature interact during early development to influence amphibian physiology. The environment can shape ecological processes through effects on an individuals' physiology. The project will combine genetic, biochemical and physiological approaches to investigate the effects of ultraviolet B and temperature on a key fitness determinant – immune system function. T ....Environmental and physiological drivers of immune function in frogs. This project aims to investigate how ultraviolet B radiation and temperature interact during early development to influence amphibian physiology. The environment can shape ecological processes through effects on an individuals' physiology. The project will combine genetic, biochemical and physiological approaches to investigate the effects of ultraviolet B and temperature on a key fitness determinant – immune system function. The project expects to provide information on how environmental conditions experienced during development influence the growth and fitness of frogs. This will improve our capacity to forecast potential ecological-level effects of environmental change on amphibians.Read moreRead less
The Impact Of The Environment And Pollution On Cognitive Health (EPOCH): Building The Knowledge Base Through International Collaboration
Funder
National Health and Medical Research Council
Funding Amount
$681,240.00
Summary
Neighbourhood environments can impact on the health of their residents. However, not much is known about their effects on cognitive decline in late life. This project will link environmental data to existing studies on ageing to examine how the neighbourhood built environment (e.g., access to services), natural environment, air pollution and noise may impact on cognitive decline and the risk of dementia in older adults and whether these effects differ in the United Kingdom and Australia.
Built Environments And Child Health In WalEs And AuStralia (BEACHES)
Funder
National Health and Medical Research Council
Funding Amount
$797,256.00
Summary
A better understanding of how the built environment drives obesity in children will inform evidence-based planning policy and practice strategies to prevent the rise in non-communicable diseases (NCDs) in future generations. We will bring together five large UK and Australian cohort studies to understand how complex and interacting built environment factors influence modifiable risk factors (physical inactivity, sedentary time, unhealthy diet) for NCD’s across childhood.
The Role Of Preconception And Perinatal Substance Use And Misuse In Childhood Social, Emotional And Behavioural Problems
Funder
National Health and Medical Research Council
Funding Amount
$1,562,250.00
Summary
This project will use perinatal and preconception data from three long-running Australian studies that have tracked the health and wellbeing of several thousand participants prior to parenthood. The aim is to understand how parental histories of substance use, and patterns of use during pregnancy, and in early life, shape offspring social, emotional and behavioural outcomes across childhood. Results will inform new approaches to preventing substance-related harms within and across generations.
Manipulative tests of metabolic theory. This project aims to take a new interdisciplinary approach to understanding how energy flows through individuals, populations, communities, and ecosystems. The project expects to develop a new framework for understanding the function of biological systems, bringing together the fields of physiology, ecology, and evolutionary biology, generating research publications, and training students in interdisciplinary research. The proposed research is anticipated ....Manipulative tests of metabolic theory. This project aims to take a new interdisciplinary approach to understanding how energy flows through individuals, populations, communities, and ecosystems. The project expects to develop a new framework for understanding the function of biological systems, bringing together the fields of physiology, ecology, and evolutionary biology, generating research publications, and training students in interdisciplinary research. The proposed research is anticipated to provide a means for understanding how management interventions can alter energy flows in biological systems, bringing benefits across the areas of climate change adaptation, conservation science, agriculture and aquaculture, and fisheries management.Read moreRead less
A new model for animal growth. This project aims to test and further develop a new theory for how animals grow. The new growth theory brings together the fields of physiology, ecology, and evolutionary biology, generating research publications, and training students. The proposed research is anticipated to provide a fundamentally new means for understanding how animals divide energy among growth and reproduction, paving the way for organismal allocation to these processes to be optimised by sele ....A new model for animal growth. This project aims to test and further develop a new theory for how animals grow. The new growth theory brings together the fields of physiology, ecology, and evolutionary biology, generating research publications, and training students. The proposed research is anticipated to provide a fundamentally new means for understanding how animals divide energy among growth and reproduction, paving the way for organismal allocation to these processes to be optimised by selective breeding or genetic manipulation, yielding potential benefits for aquaculture (enhanced growth) or re-introduction (enhanced reproduction).Read moreRead less
Epigenetic effects of environmental thyroid disruption. Anthropogenic impacts increasingly disrupt hormone-mediated responses to environmental change. The project aims to determine the interactive effects of climate warming, light-at-night, and plastic pollution on thyroid hormone signalling, and test whether these effects are passed between generations epigenetically. Epigenetic effects of endocrine disruption are one of the most important emerging conservation threats. Mathematical modelling o ....Epigenetic effects of environmental thyroid disruption. Anthropogenic impacts increasingly disrupt hormone-mediated responses to environmental change. The project aims to determine the interactive effects of climate warming, light-at-night, and plastic pollution on thyroid hormone signalling, and test whether these effects are passed between generations epigenetically. Epigenetic effects of endocrine disruption are one of the most important emerging conservation threats. Mathematical modelling of experimental data will help to predict how animals respond to anthropogenic impacts, and to acquire the tools necessary to maintain ecosystem function and services. The project will therefore have environmental benefits, as well as social benefits stemming from international collaborations and training.Read moreRead less
Investigating memory reliability in intoxicated witnesses of crime. Eyewitness testimony is a crucial piece of evidence for solving a crime. Inaccurate testimony leads to miscarriages of justice such as failed prosecutions or false convictions. Many witnesses and victims are affected by alcohol or other drugs during the crime. This project brings together a multidisciplinary team aiming to improve understanding of how intoxication with different substances affects the reliability of victim and w ....Investigating memory reliability in intoxicated witnesses of crime. Eyewitness testimony is a crucial piece of evidence for solving a crime. Inaccurate testimony leads to miscarriages of justice such as failed prosecutions or false convictions. Many witnesses and victims are affected by alcohol or other drugs during the crime. This project brings together a multidisciplinary team aiming to improve understanding of how intoxication with different substances affects the reliability of victim and witness memory accuracy. Crucially, crimes are frequently distressing; therefore the interaction between intoxication and stress urgently requires exploration. This project will significantly advance our understanding of key mechanisms behind drug effects on memory, and support fairer judicial outcomes for all. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100694
Funder
Australian Research Council
Funding Amount
$372,014.00
Summary
Does disconnection in the aging brain cause age-related movement decline? This project aims to use new neurophysiological approaches to understand the causal role of age-related changes in brain network connectivity to the movement control. Brain regions interact through complex and dynamic neural networks to control voluntary movement, but whether age-related changes in network connectivity drive age-related decline in movement control is unknown. This project will provide significant benefits ....Does disconnection in the aging brain cause age-related movement decline? This project aims to use new neurophysiological approaches to understand the causal role of age-related changes in brain network connectivity to the movement control. Brain regions interact through complex and dynamic neural networks to control voluntary movement, but whether age-related changes in network connectivity drive age-related decline in movement control is unknown. This project will provide significant benefits such as the neurophysiological knowledge required to develop targeted interventions to improve movement control in the aging population.Read moreRead less