Investigating memory reliability in intoxicated witnesses of crime. Eyewitness testimony is a crucial piece of evidence for solving a crime. Inaccurate testimony leads to miscarriages of justice such as failed prosecutions or false convictions. Many witnesses and victims are affected by alcohol or other drugs during the crime. This project brings together a multidisciplinary team aiming to improve understanding of how intoxication with different substances affects the reliability of victim and w ....Investigating memory reliability in intoxicated witnesses of crime. Eyewitness testimony is a crucial piece of evidence for solving a crime. Inaccurate testimony leads to miscarriages of justice such as failed prosecutions or false convictions. Many witnesses and victims are affected by alcohol or other drugs during the crime. This project brings together a multidisciplinary team aiming to improve understanding of how intoxication with different substances affects the reliability of victim and witness memory accuracy. Crucially, crimes are frequently distressing; therefore the interaction between intoxication and stress urgently requires exploration. This project will significantly advance our understanding of key mechanisms behind drug effects on memory, and support fairer judicial outcomes for all. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100694
Funder
Australian Research Council
Funding Amount
$372,014.00
Summary
Does disconnection in the aging brain cause age-related movement decline? This project aims to use new neurophysiological approaches to understand the causal role of age-related changes in brain network connectivity to the movement control. Brain regions interact through complex and dynamic neural networks to control voluntary movement, but whether age-related changes in network connectivity drive age-related decline in movement control is unknown. This project will provide significant benefits ....Does disconnection in the aging brain cause age-related movement decline? This project aims to use new neurophysiological approaches to understand the causal role of age-related changes in brain network connectivity to the movement control. Brain regions interact through complex and dynamic neural networks to control voluntary movement, but whether age-related changes in network connectivity drive age-related decline in movement control is unknown. This project will provide significant benefits such as the neurophysiological knowledge required to develop targeted interventions to improve movement control in the aging population.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100575
Funder
Australian Research Council
Funding Amount
$423,604.00
Summary
Does neuroplasticity protect against late life cognitive impairment? This project aims to investigate neuroplasticity across the adult lifespan, using novel neurophysiological approaches to determine its role in protecting against age-related cognitive decline. This project expects to generate new knowledge in the area of human cognitive ageing, using an innovative and interdisciplinary approach. Expected outcomes of this project include a critical understanding of the basic neural mechanisms of ....Does neuroplasticity protect against late life cognitive impairment? This project aims to investigate neuroplasticity across the adult lifespan, using novel neurophysiological approaches to determine its role in protecting against age-related cognitive decline. This project expects to generate new knowledge in the area of human cognitive ageing, using an innovative and interdisciplinary approach. Expected outcomes of this project include a critical understanding of the basic neural mechanisms of healthy brain ageing. This will provide significant benefits, such as the neurophysiological knowledge required to develop novel biological markers to detect, as well as therapeutic agents to curb, cognitive decline in the aging population.Read moreRead less
Understanding working memory: from cells to brain stimulation. This project aims to understand the neural mechanisms of working memory, a fundamental cognitive function in humans, using a novel framework which combines non-invasive brain stimulation, neuroimaging, pharmacological and experimental manipulations, and biological modelling. Expected outcomes include a critical understanding of the cellular mechanisms underlying both neural activity and working memory ability in healthy individuals a ....Understanding working memory: from cells to brain stimulation. This project aims to understand the neural mechanisms of working memory, a fundamental cognitive function in humans, using a novel framework which combines non-invasive brain stimulation, neuroimaging, pharmacological and experimental manipulations, and biological modelling. Expected outcomes include a critical understanding of the cellular mechanisms underlying both neural activity and working memory ability in healthy individuals and a detailed knowledge of how to non-invasively interact with these mechanisms using brain stimulation. This will provide significant benefits such as the development of individually optimised brain stimulation protocols, enabling tailored approaches to reliably alter brain function and cognition.Read moreRead less
Extinction of conditioned responding: Learning from the evidence of absence. When animals or people learn that a cue, or their own action, is followed by something important, they respond in anticipation of the outcome or to control it. This project investigates how these learned responses can be reduced (“extinguished”) when the conditions that established them change. It will help solve 2 outstanding theoretical and practical problems: what makes some learned behaviours resistant to extinction ....Extinction of conditioned responding: Learning from the evidence of absence. When animals or people learn that a cue, or their own action, is followed by something important, they respond in anticipation of the outcome or to control it. This project investigates how these learned responses can be reduced (“extinguished”) when the conditions that established them change. It will help solve 2 outstanding theoretical and practical problems: what makes some learned behaviours resistant to extinction or prone to relapse after being extinguished? The project will identify the factors that are most directly responsible for resistance and relapse. This could pave the way to finding solutions for the major problems that bedevil therapies designed to treat human behavioural disorders, such as addictions, gambling, and anxietyRead moreRead less
CogChip: development of a targeted genotyping chip for executive function. This project aims to use DNA sequencing technology to identify the genetics of executive function. Our capacities to focus on a task at hand, to filter distractions and to inhibit unwanted impulses, are collectively referred to as executive functions. Executive function varies on a continuum in the general population across the lifespan, with individual differences largely due to differences in underlying genetics. The pr ....CogChip: development of a targeted genotyping chip for executive function. This project aims to use DNA sequencing technology to identify the genetics of executive function. Our capacities to focus on a task at hand, to filter distractions and to inhibit unwanted impulses, are collectively referred to as executive functions. Executive function varies on a continuum in the general population across the lifespan, with individual differences largely due to differences in underlying genetics. The project proposes to leverage this knowledge to develop a customised genotyping chip, which may find application for prediction of individual differences in executive ability across multiple settings including education and industry. Expected outcomes for the project will include breakthrough insights into the biology of cognition, and a genetic read-out of individual differences in executive ability, which could have broad application including the potential to facilitate the targeting of cognitive, educational or workplace training for those most at risk of adverse outcomes.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100856
Funder
Australian Research Council
Funding Amount
$398,671.00
Summary
Oxytocin enhances the processing of environmental cues. Oxytocin is a powerful neuromodulator for social and emotional processing. Despite extensive research demonstrating pro-social and anxiolytic effects of oxytocin, the psychological processes that produce its effects are unknown. My hypothesis is that oxytocin enhances attention to cues that signal emotionally significant outcomes. This project will systematically assess the neural and psychological mechanisms underlying OT's effects using a ....Oxytocin enhances the processing of environmental cues. Oxytocin is a powerful neuromodulator for social and emotional processing. Despite extensive research demonstrating pro-social and anxiolytic effects of oxytocin, the psychological processes that produce its effects are unknown. My hypothesis is that oxytocin enhances attention to cues that signal emotionally significant outcomes. This project will systematically assess the neural and psychological mechanisms underlying OT's effects using an associative learning framework through an innovative combination of Pavlovian conditioning, behavioural pharmacology, chemogenetic and transgenic methods. This is the first project to use an associative learning framework to understand the psychological processes that produce oxytocin’s effects. Read moreRead less
The processing of fear in the medial temporal lobe. The aim of this project is to identify how fear affects information processing in the medial temporal lobe (MTL). It is significant in providing the first systematic assessment of how fear alters processing of different types of information in the MTL, including the innocuous; and how fear affects processing of memories in MTL networks, including their integration. The expected outcomes are basic knowledge regarding these effects of fear, and a ....The processing of fear in the medial temporal lobe. The aim of this project is to identify how fear affects information processing in the medial temporal lobe (MTL). It is significant in providing the first systematic assessment of how fear alters processing of different types of information in the MTL, including the innocuous; and how fear affects processing of memories in MTL networks, including their integration. The expected outcomes are basic knowledge regarding these effects of fear, and a theory of MTL function in which they are explained. The benefit of this knowledge is a better understanding of how information is processed in a normal brain, and therefore, disturbances to information processing in fear-related disorders (e.g., over-generalization of fear in post-traumatic stress).Read moreRead less
How exercise modulates neural plasticity and memory consolidation. This project aims to examine how genetic variation in humans affects the capacity of exercise to augment neural plasticity and learning. This project expects to generate new knowledge through an innovative approach combining genetics, exercise physiology, and cognitive neuroscience. It is expected the outcomes will have implications for human learning, workplace productivity, and training protocols for rehabilitation and sport. E ....How exercise modulates neural plasticity and memory consolidation. This project aims to examine how genetic variation in humans affects the capacity of exercise to augment neural plasticity and learning. This project expects to generate new knowledge through an innovative approach combining genetics, exercise physiology, and cognitive neuroscience. It is expected the outcomes will have implications for human learning, workplace productivity, and training protocols for rehabilitation and sport. Exercise is a cheap way to enhance neural plasticity and improve behavioural performance, which is of benefit to employers, our economy, and individuals. A possible future application of this research could be the personalised prescription of exercise for brain health based on an individual’s genetics.Read moreRead less
Extinction and response inhibition. Humans and other animals readily learn to perform an action if it is “reinforced” by a reward and will extinguish the action if it stops being reinforced. Popular models of learning describe extinction as the automatic outcome of a prediction-error correction process that gradually weakens, and eventually eliminates, the response-reward association. But there is much evidence that conditioned responses are not eliminated and can be quickly restored. Other evid ....Extinction and response inhibition. Humans and other animals readily learn to perform an action if it is “reinforced” by a reward and will extinguish the action if it stops being reinforced. Popular models of learning describe extinction as the automatic outcome of a prediction-error correction process that gradually weakens, and eventually eliminates, the response-reward association. But there is much evidence that conditioned responses are not eliminated and can be quickly restored. Other evidence suggests that extinction might involve more specific inhibitory processes that suppress the response without eliminating the original learning. The current project investigates the role of response inhibition in the extinction of learned responses in humans.Read moreRead less