Environmental and physiological drivers of immune function in frogs. This project aims to investigate how ultraviolet B radiation and temperature interact during early development to influence amphibian physiology. The environment can shape ecological processes through effects on an individuals' physiology. The project will combine genetic, biochemical and physiological approaches to investigate the effects of ultraviolet B and temperature on a key fitness determinant – immune system function. T ....Environmental and physiological drivers of immune function in frogs. This project aims to investigate how ultraviolet B radiation and temperature interact during early development to influence amphibian physiology. The environment can shape ecological processes through effects on an individuals' physiology. The project will combine genetic, biochemical and physiological approaches to investigate the effects of ultraviolet B and temperature on a key fitness determinant – immune system function. The project expects to provide information on how environmental conditions experienced during development influence the growth and fitness of frogs. This will improve our capacity to forecast potential ecological-level effects of environmental change on amphibians.Read moreRead less
Neural and cognitive studies of reward sensitivity and its influence on addiction-related behaviour. The proposed research aims to contribute to current scientific thinking on the influence of reward sensitivity on cognitive performance. Cognitive neuroscience research on this relationship is of major scientific interest because heightened reward sensitivity is a significant predictor of risk for a number of Australia's major social and economic problems. The findings of this project will contri ....Neural and cognitive studies of reward sensitivity and its influence on addiction-related behaviour. The proposed research aims to contribute to current scientific thinking on the influence of reward sensitivity on cognitive performance. Cognitive neuroscience research on this relationship is of major scientific interest because heightened reward sensitivity is a significant predictor of risk for a number of Australia's major social and economic problems. The findings of this project will contribute to the debate about how to manage such problems.Read moreRead less
Examining the relationship between error processing, cognitive control and emotion: a cognitive neuroscience approach. The proposed research aims to contribute to current scientific thinking on how the processing of errors influences self-monitoring and cognitive performance. The ability to monitor one's cognitive performance deteriorates with normal ageing, and is particularly affected in a range of clinical conditions, where it is a reliable predictor of a poor prognostic outcome. This project ....Examining the relationship between error processing, cognitive control and emotion: a cognitive neuroscience approach. The proposed research aims to contribute to current scientific thinking on how the processing of errors influences self-monitoring and cognitive performance. The ability to monitor one's cognitive performance deteriorates with normal ageing, and is particularly affected in a range of clinical conditions, where it is a reliable predictor of a poor prognostic outcome. This project aims to clarify understanding of the cognitive and neural processes underlying self-monitoring, as an important first step to improving rehabilitation and management methods for age-related impairments such as Alzheimer's disease, and prominent mental health conditions such as schizophrenia.Read moreRead less
The effect of temperature biofeedback on sleep and cardiac autonomic tone in young and aged adults. Peripheral heat loss is reported to promote sleep onset. To date, however, most studies examining the thermoregulatory model of sleep onset have used sedative-hypnotics with both thermoregulatory and soporific effects. We propose that a better test of a causal relationship between peripheral heat loss and sleep can be achieved by using temperature biofeedback; a promising non-invasive and non-dr ....The effect of temperature biofeedback on sleep and cardiac autonomic tone in young and aged adults. Peripheral heat loss is reported to promote sleep onset. To date, however, most studies examining the thermoregulatory model of sleep onset have used sedative-hypnotics with both thermoregulatory and soporific effects. We propose that a better test of a causal relationship between peripheral heat loss and sleep can be achieved by using temperature biofeedback; a promising non-invasive and non-drug treatment that does not have a direct effect on sleep structures. We aim to test whether increased peripheral heat loss promotes sleep onset, whether the effects are mediated by changes in autonomic tone, and whether this relationship changes with age.Read moreRead less
Improving cognitive function in the elderly. The ageing population has been identified as one of the major issues facing contemporary Australian society. For Australia, human ageing has significant societal, economic and, importantly, personal/human costs. The economic costs associated with ageing reflect decreased productivity as well as a higher incidence of a variety of illnesses including cardiovascular and respiratory disease and, importantly, neurological conditions such as Parkinson's dis ....Improving cognitive function in the elderly. The ageing population has been identified as one of the major issues facing contemporary Australian society. For Australia, human ageing has significant societal, economic and, importantly, personal/human costs. The economic costs associated with ageing reflect decreased productivity as well as a higher incidence of a variety of illnesses including cardiovascular and respiratory disease and, importantly, neurological conditions such as Parkinson's disease (PD) and Alzheimer's disease (AD). We will complete two large scale studies examining the efficacy of twelve months administration of two pharmacologically active supplements in reducing the cognitive effects of aging in elderly participants.
Read moreRead less
A developmental and neural analysis of learned and unlearned fear. This project aims to increase our understanding of the emotion of fear from both a developmental and a neural perspective. Anxiety disorders, which are characterised by the inability to appropriately regulate fear, are among the most prevelant psychological disturbances in industrialised countries. The present project involves a neurobiological analysis of fear in the developing rat, and will (i) test the dominant theoretical mod ....A developmental and neural analysis of learned and unlearned fear. This project aims to increase our understanding of the emotion of fear from both a developmental and a neural perspective. Anxiety disorders, which are characterised by the inability to appropriately regulate fear, are among the most prevelant psychological disturbances in industrialised countries. The present project involves a neurobiological analysis of fear in the developing rat, and will (i) test the dominant theoretical models of learned fear, (ii) compare the development of learned and unlearned fear, and (iii) provide a novel approach for studying whether learned behavioural responses are appropriate to the age of training or the age of testing.Read moreRead less
When is extinction not extinction? Disorders of fear and anxiety are widespread and impose significant burdens on individual sufferers and their families. This projects studies new ways of augmenting loss of fear and will identify the important behavioural mechanisms as well as critical brain pathways for this fear loss.
Manipulative tests of metabolic theory. This project aims to take a new interdisciplinary approach to understanding how energy flows through individuals, populations, communities, and ecosystems. The project expects to develop a new framework for understanding the function of biological systems, bringing together the fields of physiology, ecology, and evolutionary biology, generating research publications, and training students in interdisciplinary research. The proposed research is anticipated ....Manipulative tests of metabolic theory. This project aims to take a new interdisciplinary approach to understanding how energy flows through individuals, populations, communities, and ecosystems. The project expects to develop a new framework for understanding the function of biological systems, bringing together the fields of physiology, ecology, and evolutionary biology, generating research publications, and training students in interdisciplinary research. The proposed research is anticipated to provide a means for understanding how management interventions can alter energy flows in biological systems, bringing benefits across the areas of climate change adaptation, conservation science, agriculture and aquaculture, and fisheries management.Read moreRead less
The cognitive neuroscience of executive control: behavioural, physiological and genetic mechanisms. How genes influence our human abilities to think, reason and control behaviour has puzzled scientists for decades. The human genome project has allowed us to ask how individual genes influence these capacities. Understanding the genetics of these abilities provides a solid platform from which to launch gene discovery projects in clinical disorders where these abilities are compromised. The curr ....The cognitive neuroscience of executive control: behavioural, physiological and genetic mechanisms. How genes influence our human abilities to think, reason and control behaviour has puzzled scientists for decades. The human genome project has allowed us to ask how individual genes influence these capacities. Understanding the genetics of these abilities provides a solid platform from which to launch gene discovery projects in clinical disorders where these abilities are compromised. The current project is directly relevant to the genetics of mental disorders, such as attention deficit hyperactivity (ADHD), that place a large burden, both financially and emotionally, on our society. Understanding the genes and biological pathways that increase risk for mental disorders will ultimately lead to improved treatments for these conditions.Read moreRead less
A new model for animal growth. This project aims to test and further develop a new theory for how animals grow. The new growth theory brings together the fields of physiology, ecology, and evolutionary biology, generating research publications, and training students. The proposed research is anticipated to provide a fundamentally new means for understanding how animals divide energy among growth and reproduction, paving the way for organismal allocation to these processes to be optimised by sele ....A new model for animal growth. This project aims to test and further develop a new theory for how animals grow. The new growth theory brings together the fields of physiology, ecology, and evolutionary biology, generating research publications, and training students. The proposed research is anticipated to provide a fundamentally new means for understanding how animals divide energy among growth and reproduction, paving the way for organismal allocation to these processes to be optimised by selective breeding or genetic manipulation, yielding potential benefits for aquaculture (enhanced growth) or re-introduction (enhanced reproduction).Read moreRead less