Innovation In The Synthesis And Translation Of Research Evidence To Inform The Prevention, Management And Treatment Of Chronic Disease In Indigenous Populations
Funder
National Health and Medical Research Council
Funding Amount
$2,642,121.00
Summary
Chronic disease remains the principal cause of health inequality for Indigenous Australians. Primary care is critical to mounting a health system response. The Aboriginal community controlled sector is at the coal face of chronic disease management, yet requires the synthesis, utilisation, development, evaluation and translation of evidence to practice. CREATE was established for this purpose
Rapidly giving intravenous fluid to prevent or treat shock (fluid resuscitation) is one of the commonest treatments given to critically ill patients. Current guidelines recommend crystalloid solutions but it is unknown whether any particular crystalloid is better than others. This trial will determine whether the use of one of two crystalloid fluids, saline or PlasmaLyte, reduces the risk of organ injuries, such as kidney failure, and improves patients chances of surviving critically illness.
Treatment Of Invasively Ventilated Adults With Early Activity And Mobilisation
Funder
National Health and Medical Research Council
Funding Amount
$1,467,137.00
Summary
The sickest patients in intensive care units (ICUs) receive prolonged, invasive support for their breathing. This is currently managed with complete bed rest, and results in severe muscle weakness, increased duration of hospital stay and poor recovery. We have found that early activity and mobilisation during invasive breathing support is safe and may improve survival and recovery. We will test early activity and mobilisation in a large randomised controlled trial of 750 ICU patients.
This project will investigate the causes of respiratory disease and poor lung function across the life course. Using existing lung health data from Australia and Europe, we will determine which behavioral, environmental, occupational, nutritional, other modifiable lifestyle, or genetic factors play a role in lung health. This research will enable the development of a personalised risk predictor application for implementation with patients and health care providers as well as the general public.
Improving The Cardiometabolic Health Of People With Psychosis: The Physical Health Nurse Consultant Service
Funder
National Health and Medical Research Council
Funding Amount
$667,021.00
Summary
People with psychosis have high rates of chronic disease that reduces lifespan by 25 years. The health system struggles to provide adequate care. We developed the Physical Health Nurse Consultant service that provides physical health care coordination and will evaluate whether it improves physical health, consumer experience and cost-effectiveness. Outcomes will directly address policy initiatives to improve physical health service delivery in mental health services.
Improving Quality Of Life In Late Stage Bipolar Disorder: RCT Of A Novel Psychological Treatment
Funder
National Health and Medical Research Council
Funding Amount
$1,083,620.00
Summary
Hundreds of thousands of Australians have bipolar disorder and receive minimal benefit from existing drug and psychological treatments. ORBIT 2.0 is a new low-intensity online treatment using mindfulness strategies to improve quality of life in this poorly served ‘late stage’ group. Pilot testing suggests ORBIT is effective. This project will refine the intervention and is expected to confirm its clinical and cost effectiveness prior to international roll-out.
Improving Care Of The Dying With Chronic Heart Failure
Funder
National Health and Medical Research Council
Funding Amount
$130,000.00
Summary
Chronic heart failure is increasing in prevalence and is primarily a condition of ageing. Although chronic heart failure has worse outcomes than many cancers, patients are often denied the benefits of palliative care with its emphasis on symptom management, spirituality, emotional health and focus on family issues. This project seeks to assess the state of knowledge in Australia related to palliative care in chronic heart failure. Guidelines and care maps appropriate to Australian conditions wil ....Chronic heart failure is increasing in prevalence and is primarily a condition of ageing. Although chronic heart failure has worse outcomes than many cancers, patients are often denied the benefits of palliative care with its emphasis on symptom management, spirituality, emotional health and focus on family issues. This project seeks to assess the state of knowledge in Australia related to palliative care in chronic heart failure. Guidelines and care maps appropriate to Australian conditions will be developed and their usefulness assessed in improving care of patients and their families.Read moreRead less
Improving The Mental Health Outcomes Of People With Intellectual Disability
Funder
National Health and Medical Research Council
Funding Amount
$1,189,979.00
Summary
Australians with intellectual disability (ID) have very high rates of mental illness but experience very poor access to mental health services. Our research will develop a sound evidence base on the profile of mental ill health, service use, pathways to care and mental health policy for people with intellectual disability. Together with consumers and support persons we will examine ways to improve mental health services for people with intellectual disability.
From Brain Maps To Mechanisms: Modeling The Pathophysiology Of Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
My Fellowship will develop a framework that integrates brain imaging data with mathematical models of the brain to help understand the mechanisms responsible for schizophrenia. By linking functional Magnetic Resonance Imaging (fMRI) measurements to models of their underlying causes, the work may lead to new treatments that target the specific dysfunction in individuals with this debilitating brain disorder.
Ascending Neural Networks And Behavioural State Control
Funder
National Health and Medical Research Council
Funding Amount
$727,758.00
Summary
Our research aims to describe and understand newly identified nerve pathways or 'networks' in brain that control physiological homeostasis or balance and complex behaviours, including levels of arousal and motivation, sleep/wake patterns, learning and memory, and emotions such as fear and anxiety