Exploiting The Pharmacokinetic And Pharmacodynamic Properties Of Bile Acid Receptor Agonists To Treat Liver Disease
Funder
National Health and Medical Research Council
Funding Amount
$653,952.00
Summary
We have generated preliminary data suggesting that chemicals made by the liver, called bile acids, act on fat cells to release a hormone called adiponectin. In liver disease adiponectin has favorable effects, including reducing liver inflammation and fibrosis (scarring). By using drugs that mimic the action of bile acids we expect that adiponectin production by fat cells can be increased, creating a new way to treat patients with chronic liver diseases.
Efficacious Targeting Of Therapeutic Stem Cells To Diseased Livers
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
This project focuses on the challenging area of effective and optimal dosing of stem cell-based therapy for liver diseases. I will investigate the fate and therapeutic effects of natural, surface-modified stem cells and cell-derived vesicles in the body and in liver regions using mathematical models. My key goal is advance cell therapy by providing better dosing and cell engineering strategies.
Physiologically-based Pharmacokinetics And Pharmacodynamics Of Therapeutic Stem Cells For Liver Disease
Funder
National Health and Medical Research Council
Funding Amount
$848,710.00
Summary
This project focuses on the challenging area of effective and optimal dosing cell-based therapy for liver diseases. We will investigate the fate and therapeutic effects of natural, modified and artificial therapeutic cells in the body and in liver regions using a physiologically-based kinetic model. Our key goal is advance cell therapy by providing a better understanding and dosing guidelines.