Personalizing Antipsychotic Medicines To Improve Patient Outcomes In Schizophrenia: Development Of Decision Support Tools Using Pharmacometabolomics And Pharmacometrics
Efficacious Targeting Of Therapeutic Stem Cells To Diseased Livers
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
This project focuses on the challenging area of effective and optimal dosing of stem cell-based therapy for liver diseases. I will investigate the fate and therapeutic effects of natural, surface-modified stem cells and cell-derived vesicles in the body and in liver regions using mathematical models. My key goal is advance cell therapy by providing better dosing and cell engineering strategies.
Translating A Drop Of Blood Into Effective Antibiotic Dosing In Infants And Children
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
The optimal use of currently available antibiotics is of utmost importance at a time when few new antibiotics are being developed and there is a continued emergence of antibiotic resistant ‘superbugs’. This Fellowship will establish evidence-based, effective antibiotic dosing regimens for children with severe infection - using just a drop of blood. By applying innovation in microsampling, my research will advance our treatment of infection and result in better outcomes for sick children.
Improving The Therapeutic Use Of Anti-infective Agents: Application Of Pharmacometrics For Rational Dosing Regimen Design
Funder
National Health and Medical Research Council
Funding Amount
$313,390.00
Summary
There is no field of medicine in which the individualisation of medicines is more important than in infectious diseases – appropriate doses must be administered to maximise efficacy and to minimise side effects and the emergence of drug-resistance. This fellowship will use the emerging science of pharmacometrics to investigate factors contributing to the variability in response to anti-infective medications and to optimise dosing regimens for the best use of these drugs in clinical practice.