Disentangling The Interrelationship Between Multimordibity, Multimedicine Use, And Cardiovascular Health
Funder
National Health and Medical Research Council
Funding Amount
$480,978.00
Summary
Australians are living longer, but are also living with more health conditions and taking more medicines to treat those conditions. For people with cardiovascular disease (CVD), this is a problem as hundreds of non-cardiac medicines known to increase the risk of cardiovascular events, such as myocardial infarction, stroke, or heart failure. We will take a holistic, patient-centred approach determine the true burden of CVD related to use of medicines to treat comorbid conditions in Australia.
Blocking Paths To Suicide: A Data Linkage Program To Identify Modifiable Risk Factors For Self-poisoning And Suicide In Australia
Funder
National Health and Medical Research Council
Funding Amount
$501,205.00
Summary
This research examines the relationship between medicines use and suicide. Some medicines may be more toxic than others and identification of these could allow for targeted restrictions. In addition, medication use practices may influence self-harm and suicide. This research will identify patterns (e.g. non-adherence prior to death, incorrect doses) to pinpoint beneficial or harmful practices. This will improve outcomes and help guide suicide prevention through targeted legislation and policy.
Immediate And Long-term Safety Of Prescription Opioids In Pregnancy
Funder
National Health and Medical Research Council
Funding Amount
$447,603.00
Summary
Little is known about the consequences of prescription opioid use during pregnancy for fetal and childhood development. In this study covering over 5 million mother-child pairs, we will investigate the safety of opioid use in pregnancy, by combining rich data sources from Australia, and the 5 Nordic countries. We will translate findings into policy, guidelines and messaging for medicine consumers and prescribers to protect the safety of women and children.
Centre Of Research Excellence In Medicines Intelligence
Funder
National Health and Medical Research Council
Funding Amount
$2,500,000.00
Summary
The NHMRC Centre of Research Excellence in Medicines Intelligence is a co-ordinated research program that will accelerate the development and translation of evidence on prescribed medicines use and outcomes for regulators and payers. The CRE is perfectly placed to embrace the national ‘call to action’ from the Health Minister's recent announcement to establish Quality Use of Medicine Safety as a National Health Priority.
Optimising The Management Of Comorbidities In Dementia: Reducing Disparaties And Improving Clinical Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$603,894.00
Summary
Many individuals with dementia also have other chronic medical conditions. This research will help us better understand the comorbidities experienced by people with dementia and the impact these have on clinical outcomes This can lead to the development of consumer-centred management strategies. By ensuring the appropriate, equitable and timely treatment of comorbidities in people with dementia, there is potential to optimise the quality of life and health of people with dementia.
The Use Of Real-World Evidence To Support Regulatory And Reimbursement Decisions
Funder
National Health and Medical Research Council
Funding Amount
$91,538.00
Summary
Traditionally, medicines are studied extensively in clinical trials before they are widely available. More recently, some medicines have been allowed to enter the market without complete data on their benefits and risks. This means that these issues can only be studied once a medicine is on the market and used in routine clinical practice; this is referred to as real-world evidence. This research evaluates if this evidence is sufficient to prove that a medicine is safe and that it works
Why Is There An Increased Risk Of Severe Adverse Perinatal Outcomes After The Use Of Clomiphene Citrate For Infertility Treatment?
Funder
National Health and Medical Research Council
Funding Amount
$570,065.00
Summary
Clomiphene citrate (CC) has been a first line treatment for female infertility internationally since the 1960’s. However, safety studies using routine prescribing practices were never performed, and numerous data sources now indicate that CC is associated with major adverse outcomes if the fetus is inadvertently exposed. We are linking prescription data to perinatal outcomes to confirm how CC is associated with adverse events so as to inform prescriber and practice change.
Optimising Medicine Regimens For People With Dementia: Maintaining Function, Maximising Quality Of Life And Preventing Adverse Events
Funder
National Health and Medical Research Council
Funding Amount
$715,017.00
Summary
I am a pharmacist based at Monash University. My expanding research team generates and applies evidence to optimise medicine regimens for people with dementia. My research assesses the risks and benefits of medicines for dementia and other health conditions. I will also focus on research training and capacity building. My research ensures people with dementia and their clinicians are equipped with the best evidence to inform medicines management decisions to optimise health outcomes.
Enabling Evidence-informed Policy To Address Australia's Opioid Crisis
Funder
National Health and Medical Research Council
Funding Amount
$607,538.00
Summary
Australia has seen a near doubling of opioid-related mortality in the past decade. Recently, a range of state and national policy changes have been made to address the growing number of opioid-related deaths, yet the evidence for these kinds of policy changes is conflicting. This study will use prescribing data from general practice in combination with hospital data to understand the impact of three types of Australian policy interventions on opioid prescribing and opioid-related harm.
Optimising Pharmaceutical Care For People With Dementia In Acute Care Settings
Funder
National Health and Medical Research Council
Funding Amount
$719,637.00
Summary
Delivering appropriate acute care services for people with dementia is a major healthcare challenge in Australia. People with dementia do not receive appropriate care in hospitals and are more likely to experience worse clinical outcomes compared to people without dementia. This proposal will establish the first large-scale multi-centre cohort of inpatients with dementia, to systematically investigate the impact of hospitalisation on prescribing, clinical and patient-centred outcomes.