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Australian Laureate Fellowships - Grant ID: FL160100170
Funder
Australian Research Council
Funding Amount
$2,887,531.00
Summary
Scaling in biology: size control at the cell, organelle and organism level. This project aims to decipher the universal mechanisms that coordinate growth with division and thereby dictate the size of the cell. It would investigate this question from the triangulating perspective of evolution using yeast and animal models. It plans to interrogate the complex sub-networks that govern cell size using novel genome-scale reagent sets for systematic genetics and other approaches. It would integrate th ....Scaling in biology: size control at the cell, organelle and organism level. This project aims to decipher the universal mechanisms that coordinate growth with division and thereby dictate the size of the cell. It would investigate this question from the triangulating perspective of evolution using yeast and animal models. It plans to interrogate the complex sub-networks that govern cell size using novel genome-scale reagent sets for systematic genetics and other approaches. It would integrate this data in predictive mathematical models of size control that illuminate how the cell processes size-related information, and how size mechanisms evolve to impact form and function in biology. This research is expected to have commercial applications in biotechnology processes and bioengineering.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL200100220
Funder
Australian Research Council
Funding Amount
$3,364,492.00
Summary
Understanding host-microbiome signalling axes in ageing. Ageing is an inevitable biological phenomenon and is characterised by alterations in multiple biochemical, immunological and mechanical processes, which are influenced by the gut bacteria. Poor ageing exerts a heavy socioeconomic burden both nationally and globally. The aim of this proposal is to deepen understanding of host-microbiome signalling in ageing by bringing together next generation sequencing technologies to characterise age-ass ....Understanding host-microbiome signalling axes in ageing. Ageing is an inevitable biological phenomenon and is characterised by alterations in multiple biochemical, immunological and mechanical processes, which are influenced by the gut bacteria. Poor ageing exerts a heavy socioeconomic burden both nationally and globally. The aim of this proposal is to deepen understanding of host-microbiome signalling in ageing by bringing together next generation sequencing technologies to characterise age-associated change in gut bacterial composition, metabolic profiling to identify changes in functionality of the ageing microbiome and a combination of in vitro and in vivo screening approaches to establish molecular mechanisms. The new knowledge will facilitate development of improved models of health care.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL210100071
Funder
Australian Research Council
Funding Amount
$3,246,000.00
Summary
“L-form” bacteria: basic science, antibiotics, evolution and biotechnology. This Fellowship addresses key gaps in knowledge about cell wall deficient bacteria called L-forms: an altered state of bacteria with intriguing properties both structurally and functionally. The main aims of the research program are to improve our understanding of the basic biology of L-forms and employ them as tools in several important ways: for understanding the mechanisms of cell wall synthesis and how antibiotics wo ....“L-form” bacteria: basic science, antibiotics, evolution and biotechnology. This Fellowship addresses key gaps in knowledge about cell wall deficient bacteria called L-forms: an altered state of bacteria with intriguing properties both structurally and functionally. The main aims of the research program are to improve our understanding of the basic biology of L-forms and employ them as tools in several important ways: for understanding the mechanisms of cell wall synthesis and how antibiotics work, as models for early steps in the evolution of cellular life, and as a significant new platform for the production of proteins and fine chemicals. Outcomes and benefits include improved understanding of how to generate new antibiotics, and the development of new platforms for Australian biotechnology and biocommerce.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL170100019
Funder
Australian Research Council
Funding Amount
$2,606,250.00
Summary
Proteins in motion - new tools for biotechnology. This project aims to assess the function of proteins by monitoring their motions using new nuclear magnetic resonance (NMR) spectroscopy techniques. As snapshots of 3D protein structures have been determined by crystallography, the new tools are designed to analyse functionally important motions in solution. A facility for ultrafast (> 100 kHz) magic angle spinning NMR spectroscopy of proteins in the semi-solid state will bring cutting-edge know- ....Proteins in motion - new tools for biotechnology. This project aims to assess the function of proteins by monitoring their motions using new nuclear magnetic resonance (NMR) spectroscopy techniques. As snapshots of 3D protein structures have been determined by crystallography, the new tools are designed to analyse functionally important motions in solution. A facility for ultrafast (> 100 kHz) magic angle spinning NMR spectroscopy of proteins in the semi-solid state will bring cutting-edge know-how to Australia and allow the interrogation of 3D structure and dynamics in selected protein regions. The expected outcomes of the project will have immediate benefits for the rational engineering of biocatalysts and in the design of lead compounds in drug development.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL220100059
Funder
Australian Research Council
Funding Amount
$2,937,786.00
Summary
Digital chemistry and catalysis: redefining reactions in confined systems. This Laureate program aims to initiate a new era of chemical catalysis and reaction manipulation via an entirely novel nanofluidic approach discovered in Australia. By further studying this phenomenon, it aims to deliver new insights into what drives chemical reactions in confined systems controlled by applied electric fields. It will also develop novel technology platforms to miniaturise and enable on-demand software-con ....Digital chemistry and catalysis: redefining reactions in confined systems. This Laureate program aims to initiate a new era of chemical catalysis and reaction manipulation via an entirely novel nanofluidic approach discovered in Australia. By further studying this phenomenon, it aims to deliver new insights into what drives chemical reactions in confined systems controlled by applied electric fields. It will also develop novel technology platforms to miniaturise and enable on-demand software-controlled (digital) chemistry, with broad applications in pharmaceutical, biotechnology and chemical industries. Project success will have a profound impact in many areas of modern society, the environment and the high-tech and manufacturing industry, while further enhancing Australia's sovereign manufacturing capability.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL230100178
Funder
Australian Research Council
Funding Amount
$3,343,741.00
Summary
Nonmetals for green catalysis. This proposal aims to develop nonmetal materials and technologies for frontier green catalysis that is targeted to contaminant degradation and chemical synthesis by catalytic oxidation processes. The project will systematically unveil the intrinsic nature of nonmetal elements in heterogeneous catalysis, develop rational design principles, and achieve scaling-up of intelligent nanomaterials and integrated green catalytic systems for high reactivity and selectivity. ....Nonmetals for green catalysis. This proposal aims to develop nonmetal materials and technologies for frontier green catalysis that is targeted to contaminant degradation and chemical synthesis by catalytic oxidation processes. The project will systematically unveil the intrinsic nature of nonmetal elements in heterogeneous catalysis, develop rational design principles, and achieve scaling-up of intelligent nanomaterials and integrated green catalytic systems for high reactivity and selectivity. This cross-disciplinary research will deliver benefits to Australian industry in water treatment and fine chemical synthesis, foster Australian R&D in green technologies, synthesise catalysts from natural resources and industrial waste, and promote strong sustainability outcomes.Read moreRead less