Pharmacology Of Potential Anti-Tumour Agents: Iron Chelators Of The BpT Class
Funder
National Health and Medical Research Council
Funding Amount
$585,455.00
Summary
Pharmacology of Potential Anti-Tumour Agents: Iron Chelators of the BpT Class Cancer cells have a high iron requirement for DNA synthesis and many clinical trials showed Fe chelators are effective anti-cancer drugs. Their potential to act as anti-tumour agents has been confirmed by the entrance of Triapine into widespread NCI clinical trials. In this NHMRC Renewal, we will perform pharmacological and preclinical studies to promote the development of BpT chelators as novel anti-tumour agents.
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revol ....ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revolutionizing diagnosis and therapy in many diseases. The CoE will be the focus of bio-nano research activity in Australia, uniting universities, research agencies, institutes and companies. The expected outcomes are better diagnostic and therapeutic tools designed via an enhanced understanding of the bio-nano-interface.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100026
Funder
Australian Research Council
Funding Amount
$178,839.00
Summary
Ultrafast magic angle spinning solid-state nuclear magnetic resonance capability. This project aims to extend an existing nuclear magnetic resonance (NMR) spectrometer for structural investigations of proteins in the solid state. Many proteins, such as amyloids and flexible proteins, cannot be studied by X-ray crystallography, solution NMR spectroscopy or cryoelectron microscopy, because they cannot be crystallised or are not sufficiently soluble, or are structurally too heterogeneous. This proj ....Ultrafast magic angle spinning solid-state nuclear magnetic resonance capability. This project aims to extend an existing nuclear magnetic resonance (NMR) spectrometer for structural investigations of proteins in the solid state. Many proteins, such as amyloids and flexible proteins, cannot be studied by X-ray crystallography, solution NMR spectroscopy or cryoelectron microscopy, because they cannot be crystallised or are not sufficiently soluble, or are structurally too heterogeneous. This project will extend the capability of an existing 800 MHz NMR spectrometer to solid-state NMR. By offering ultrafast magic angle spinning speeds, the system aims to afford greatly enhanced sensitivity and multidimensional NMR spectra of protein systems not previously amenable to structural analysis by NMR spectroscopy or other techniques. This will have important applications in biotechnology and biomedicine.Read moreRead less
Intercultural understanding in primary and secondary schools. What facilitates or impedes intercultural understanding in children, adolescents and schools? How can this be addressed? How can we know what makes a difference? This project answers these questions at the individual, school and national level using a novel cultural systems approach and methodological and technological innovations.
Improving wellbeing through student participation at school. Current evidence suggests child and youth participation in matters affecting their lives has many benefits, but little is known about how this is perceived and practiced in education. This research aims to improve knowledge about processes and outcomes of student participation at school, particularly in relation to improving wellbeing. The project is timely and significant because recent reforms in education now require a greater empha ....Improving wellbeing through student participation at school. Current evidence suggests child and youth participation in matters affecting their lives has many benefits, but little is known about how this is perceived and practiced in education. This research aims to improve knowledge about processes and outcomes of student participation at school, particularly in relation to improving wellbeing. The project is timely and significant because recent reforms in education now require a greater emphasis on engaging students more directly in decisions about their education, including those with special needs. Schools urgently require knowledge about the key elements of participation that impact on wellbeing and a tool for measuring and monitoring their performance in facilitating these elements.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100085
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
Regional facility for macromolecular x-ray crystallography. This facility in the southern NSW/ACT region will allow research into structures of biological molecules. Research at the facility will contribute to advances in understanding of processes in living organisms, new drugs and new biotechnology with national and international significance.
A Transmission-Blocking Vaccine To Prevent Toxoplasmosis
Funder
National Health and Medical Research Council
Funding Amount
$850,225.00
Summary
Toxoplasma gondii causes a globally important zoonotic disease. It is transmitted by cats, and finds its way into our food chain via infected meat and contaminated water. We have used a unique functional genomics pipeline to discover proteins crucial for reproduction of Toxoplasma in the cat. We will now test combinations of these proteins to immunise cats and prove that we can develop a vaccine that blocks transmission of this highly significant parasitic disease.
More than a Roof Overhead: Meeting the Need for a Sustainable Housing System in Remote Indigenous Communities. Many Indigenous Australians live in substandard and over-crowded accommodation, and experience poor health, education, family stability and child-safety outcomes as a result. The lack of improvement in this situation is largely due to levels of funding and approaches to construction and management inadequate to the scale of the problem. This situation is changing and new funding and po ....More than a Roof Overhead: Meeting the Need for a Sustainable Housing System in Remote Indigenous Communities. Many Indigenous Australians live in substandard and over-crowded accommodation, and experience poor health, education, family stability and child-safety outcomes as a result. The lack of improvement in this situation is largely due to levels of funding and approaches to construction and management inadequate to the scale of the problem. This situation is changing and new funding and policies are being established. The researchers will work alongside housing providers and selected Indigenous communities in Western Australia and Northern Territory to develop procurement, construction and housing management practices that will meet the critical need for more affordable, appropriate and sustainable housing.Read moreRead less
School principals’ diminishing wellbeing. School principals’ diminishing wellbeing. This project aims to investigate the effect of State Education Departments’ policy interventions designed to improve school principals’ flagging wellbeing. Increasing competition, accountability and public scrutiny make principals stressed; since their influence on students is second only to teachers’, this threatens Australia’s socioeconomic outcomes. The project will map policy interventions to changes in princ ....School principals’ diminishing wellbeing. School principals’ diminishing wellbeing. This project aims to investigate the effect of State Education Departments’ policy interventions designed to improve school principals’ flagging wellbeing. Increasing competition, accountability and public scrutiny make principals stressed; since their influence on students is second only to teachers’, this threatens Australia’s socioeconomic outcomes. The project will map policy interventions to changes in principals’ motivation and wellbeing, and share information about the most productive and cost effective interventions with key stakeholders across Australia. This research could reverse the declining wellbeing of Australia’s school leaders.Read moreRead less
Children, Community and Social Capital in Australia. Contributing to our understanding of children's roles and contributions to their communities in Australia, this research will strengthen the basis for policies and interventions relating to social inclusion, community strengthening, children's well-being and family policy. Currently, there is a strong policy focus on children's issues in Australia, but children's own experiences and perspectives are often missing from policy deliberations. T ....Children, Community and Social Capital in Australia. Contributing to our understanding of children's roles and contributions to their communities in Australia, this research will strengthen the basis for policies and interventions relating to social inclusion, community strengthening, children's well-being and family policy. Currently, there is a strong policy focus on children's issues in Australia, but children's own experiences and perspectives are often missing from policy deliberations. This research will provide the foundation for policy and interventions that are inclusive of children and value children as community members and citizens. Read moreRead less