Non-discriminatory, universal and sensitive detection technologies for fluid based separation techniques in the pharmaceutical industry. The proposed research is focused on the specific needs of Australian and global pharmaceutical industries, and addresses a problem which is becoming increasingly significant with new classes of pharmaceuticals. Successful achievement of the goals of the project will result in major savings of cost and time during drug development and will lead to the productio ....Non-discriminatory, universal and sensitive detection technologies for fluid based separation techniques in the pharmaceutical industry. The proposed research is focused on the specific needs of Australian and global pharmaceutical industries, and addresses a problem which is becoming increasingly significant with new classes of pharmaceuticals. Successful achievement of the goals of the project will result in major savings of cost and time during drug development and will lead to the production of safer drugs. The project will expand collaboration between Australia researchers and the world's largest pharmaceutical company. Specialised training will be provided to both postdoctoral and postgraduate researchers, positioning them to make strong contributions to Australia's growing pharmaceutical industry.Read moreRead less
Rapid method development in pharmaceutical analysis using quality-by-design principles. Chemical analysis using separation methods underpins all stages of drug design and analysis. This project will generate new approaches to greatly reduce the time taken to develop a new method of analysis. This will be achieved through development of new computerised techniques for rapid screening, selection and optimisation of analytical methods.
A New Platform for Developing a Compound Against Herpes Simplex Virus. This project aims to further explore the research team’s recent fundamental discovery of a protein found naturally in an Australian abalone that inhibits viral entry by blocking three key viral glycoproteins. We would aim to utilise this knowledge towards development of a new class of therapeutics against Herpes simplex viruses (HSV) and their consequent infections. The new therapeutics could overcome the low bioavailability ....A New Platform for Developing a Compound Against Herpes Simplex Virus. This project aims to further explore the research team’s recent fundamental discovery of a protein found naturally in an Australian abalone that inhibits viral entry by blocking three key viral glycoproteins. We would aim to utilise this knowledge towards development of a new class of therapeutics against Herpes simplex viruses (HSV) and their consequent infections. The new therapeutics could overcome the low bioavailability of current drugs and thus significantly shorten the recurrence period. Such new drugs may have broad applicability.Read moreRead less
Improving regional secondary students' learning and well-being. Given the academic under-performance and lower life opportunities of Australian regional and rural students compared to their metropolitan counterparts, this research has the potential to make a significant social, cultural and economic contribution to the community. This research will be useful in developing an evidence-based framework to guide policy and practice in implementing an effective systematic approach to regional educati ....Improving regional secondary students' learning and well-being. Given the academic under-performance and lower life opportunities of Australian regional and rural students compared to their metropolitan counterparts, this research has the potential to make a significant social, cultural and economic contribution to the community. This research will be useful in developing an evidence-based framework to guide policy and practice in implementing an effective systematic approach to regional education and, where appropriate, other contexts. The research's economic benefit centres on gains for individuals, local communities, and the nation in enhancing regional students' academic achievements, sense of well-being and aspirations; leading to more productive citizens.Read moreRead less
Building futures for young Australians at risk: a coordinated measurement framework and data archive. This project will build a national data base of evidence about and for programs that address the needs of the 16 per cent of young Australians currently at risk of school non-completion. It will generate important knowledge for program improvement and sustainability and coordination of evidence across diverse and fragmented programs.
Student retention beyond the compulsory schooling years in rural, regional and disadvantaged communities. This project will incorporate longitudinal mixed-methods study to investigate the factors that influence student retention in schooling beyond the compulsory years in rural, regional and disadvantaged communities. Research outcomes will identify best-practice educational strategies to enhance retention in such communities across Australia.
Molecular tools for understanding, predicting and managing flowering and reproductive development in Brassica oleracea. This project integrates basic research with application to a significant horticultural industry, building on Australia's position as a leader in world research on molecular and genetic regulation of flowering. The project will strengthen Australia's research reputation in this field, provide new tools for cultivar screening in and management of B. oleracea seed crops. The proj ....Molecular tools for understanding, predicting and managing flowering and reproductive development in Brassica oleracea. This project integrates basic research with application to a significant horticultural industry, building on Australia's position as a leader in world research on molecular and genetic regulation of flowering. The project will strengthen Australia's research reputation in this field, provide new tools for cultivar screening in and management of B. oleracea seed crops. The project will deliver training for 3 PhD students at the interface between basic and applied research. A shortage of skilled scientists with ability to link understanding of plant development at the molecular/genetic level with improved crop management practices has been identified by the horticultural sector as a major challenge. Read moreRead less
The role of phytotoxins in ray blight disease of pyrethrum and significance of toxin tolerance to disease resistance. Ray blight disease, caused by Phoma ligulicola, is the greatest threat to the Australian pyrethrum industry causing $2.0M in annual losses. We aim to clarify the pathology of P.ligulicola in pyrethrum, focussing on the role of fungal toxins during infection. Toxin importance in disease will be determined through histology and induction of toxin- pathogen mutants. Toxins will be ....The role of phytotoxins in ray blight disease of pyrethrum and significance of toxin tolerance to disease resistance. Ray blight disease, caused by Phoma ligulicola, is the greatest threat to the Australian pyrethrum industry causing $2.0M in annual losses. We aim to clarify the pathology of P.ligulicola in pyrethrum, focussing on the role of fungal toxins during infection. Toxin importance in disease will be determined through histology and induction of toxin- pathogen mutants. Toxins will be characterised and used in tissue culture to select obtain toxin tolerant pyrethrum clones that will be evaluated for agronomic performance and disease resistance. Successful development of resistant clones will decrease production costs, minimise risk of fungicide resistance development and reduce environmental pollution.Read moreRead less
Reasonable Adjustments to Maths for Students with Intellectual Disabilities. Reasonable adjustments to secondary mathematics – parents want it, students need it, the Australian law requires it – but how do teachers achieve it? The aim of this project is to find ways to adjust, teach and assess secondary mathematics for students with intellectual and developmental disabilities. The significance of this study is in solving a problem facing teachers who are required by law to teach mathematics with ....Reasonable Adjustments to Maths for Students with Intellectual Disabilities. Reasonable adjustments to secondary mathematics – parents want it, students need it, the Australian law requires it – but how do teachers achieve it? The aim of this project is to find ways to adjust, teach and assess secondary mathematics for students with intellectual and developmental disabilities. The significance of this study is in solving a problem facing teachers who are required by law to teach mathematics without evidence informed approaches. Expected outcomes are an evidence-base for reasonable adjustments to secondary mathematics and approaches and strategies for teachers for inclusive practices. If ways for teaching year-level mathematics to learners with intellectual disability are developed, many more students may benefit.
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Making Crime Pay: Manufacturing Heritage Experiences in a Digital Age. This project aims to create digital tools to allow visitors to experience Australian convict sites and historical big data in new and novel ways. The project expects to forge a synergistic long-term relationship between archives, historical sites and research programs through pioneering thematic digital storytelling techniques, allowing audiences to access research data not previously curated for public consumption. Expected ....Making Crime Pay: Manufacturing Heritage Experiences in a Digital Age. This project aims to create digital tools to allow visitors to experience Australian convict sites and historical big data in new and novel ways. The project expects to forge a synergistic long-term relationship between archives, historical sites and research programs through pioneering thematic digital storytelling techniques, allowing audiences to access research data not previously curated for public consumption. Expected outcomes include enhanced international and disciplinary collaborations, generating standards for curating digital site, archival and collection data, and new means of communicating research results to a wider public, especially descendants. This should provide significant benefits to heritage site operators. Read moreRead less