Optimisation Of Salmonella Genotyping And Epidemiological Data Analysis For Detection And Investigation Of Outbreaks
Funder
National Health and Medical Research Council
Funding Amount
$508,051.00
Summary
Bacteria known as salmonella are the most important causes of food-borne diarrhoeal disease. They occasionally cause potentially fatal septicaemia, especially in young children and people with underlying disease. We estimate that more than 80,000 cases of salmonella infection occur in Australia, each year, at a cost to the community of $37 million. Salmonella are divided into more than 2000 different types, but one - called Typhimurium - causes about 40% of infections and a few others cause most ....Bacteria known as salmonella are the most important causes of food-borne diarrhoeal disease. They occasionally cause potentially fatal septicaemia, especially in young children and people with underlying disease. We estimate that more than 80,000 cases of salmonella infection occur in Australia, each year, at a cost to the community of $37 million. Salmonella are divided into more than 2000 different types, but one - called Typhimurium - causes about 40% of infections and a few others cause most of the rest. This means that is difficult to distinguish cases of salmonella infection that have originated from one source (an outbreak) from cases that have originated from another. Without this information, is it hard to track the source, which is usually inadequately cooked meat or chicken another food that has been contaminated with salmonella after preparation. There are several existing methods for fingerprinting salmonella, but they are quite slow or do not distinguish different strains well enough to identify outbreaks quickly. This means that sources of contaminated food are often not identified in time to prevent more cases occurring. We aim to develop a faster and more discriminatory system for fingerprinting salmonella, based on novel technology that can identify many small genetic sequences that occur in different combinations in different strains. As well, we will develop electronic scanning tools that will link the fingerprints of the salmonella strains with information about the people infected with them, such as the types of food and places where they have eaten, to identify patterns or clusters that indicate a common source. The more rapidly this can be done the sooner the source of contaminated food can be found and eliminated and additional cases can be prevented. This has important implications for public health - it will increase food safety and reduce illness and economic loss.Read moreRead less
Systematic Revision Of The Australian Fishes Of The Family Pomadasyidae
Funder
Fisheries Research and Development Corporation
Summary
Objectives: 1. Study the fishes of the family Pomadasyidae in the scientific collection of the Australian Museum Sydney & the National Museum Melbourne
Monoclonal antibodies, such as the cancer therapeutic Pembrolizumab, have revolutionised the treatment of cancer and many inflammatory conditions. With over $100 billion in sales in 2018, they also underpin a growing biotech industry. We have developed a highly specific, high affinity therapeutic antibody candidate, and demonstrated efficacy in animal models of malignancy. This project will advance and develop this monoclonal, allowing us to initiate clinical studies in patients.
The development of the Fishnames project has been an ongoing concern for industry and the Fisheries Research Development Corporation.
The terms of reference (ToR) have been developed and wll be provided to workshop participants for consideration and feedback. The ToR include:
1) Report that details recommended changes to the objectives of the Fishnames process.
2) Changes to the Fishnames process.
3) The composition of the Fishnames committee.
4) Brie ....The development of the Fishnames project has been an ongoing concern for industry and the Fisheries Research Development Corporation.
The terms of reference (ToR) have been developed and wll be provided to workshop participants for consideration and feedback. The ToR include:
1) Report that details recommended changes to the objectives of the Fishnames process.
2) Changes to the Fishnames process.
3) The composition of the Fishnames committee.
4) Brief ‘user friendly’ summary of the project and outcomes suitable for publication on the FRDC website. Objectives: 1. Recommend changes to the objectives of the Fishnames process. 2. Chang to the Fishnames process. 3. The composition of the Fishnames committee. 4. A brief ‘user friendly’ summary of the project and outcomes suitable for publication on the FRDC website Read moreRead less
Monoclonal antibodies, such as the breast cancer therapeutic Herceptin, have revolutionised the treatment of cancer and inflammatory conditions. Will over $30 billion sales in 2011, they have also spawned a growing biotech industry. We have a generated a highly specific monoclonal antibody, which has shown efficacy in models of disease. This project will further advance and develop this monoclonal, allowing us to initiate clinical studies in patients.
Development Of Stable Human Antibody Phage Display Libraries
Funder
National Health and Medical Research Council
Funding Amount
$539,644.00
Summary
Antibodies are blockbuster therapeutics for the treatment of cancer and inflammation. Unfortunately, they often display limited stability which greatly hinders development and production. This project focuses on the construction of large libraries of stable antibodies, thereby streamlining the development of new therapeutics.
A Program To Develop A Consensus As To "marketing" Names Of Fish Throughout Australia And To Publicise To The Trade And To The Public These "marketing" Names
Funder
Fisheries Research and Development Corporation
Summary
Objectives: 1. Enable production of a list of Australian and imported commercial fish, showing the scientific names, local names in each State and a suggested marketing name for each variety