Standardised Outcomes In Nephrology – Peritoneal Dialysis (SONG-PD): Establishing A Core Outcome Set In Peritoneal Dialysis
Funder
National Health and Medical Research Council
Funding Amount
$66,502.00
Summary
Standardised Outcomes in Nephrology-Peritoneal Dialysis study aims to establish a set of core outcomes for trials in PD based on the shared priorities of all stakeholders, so that outcomes of most relevance for decision making can be evaluated, and that interventions can be compared reliably.
Culture-independent Microbiology: Reducing Delays In The Diagnosis Of Severe Infections And Detection Of Antimicrobial Resistance From Days To Hours.
Funder
National Health and Medical Research Council
Funding Amount
$949,589.00
Summary
Serious infections require early effective antibiotic treatment. To provide evidence that an antibiotic will be effective, current tests take 2-5 days and this leads to a reliance on broad spectrum antibiotics, which can cause harm. Our new diagnostic methods, can produce results in 4-6 hours. We will demonstrate the real-world benefit of these methods by assessing samples taken from patients with three high risk infections and compare our test to currently available results.
The Australian Peritoneal Dialysis Outcomes And Practice Patterns Study (PDOPPS)
Funder
National Health and Medical Research Council
Funding Amount
$489,749.00
Summary
Peritoneal dialysis (PD) is a form of home dialysis that is both substantially cheaper and associated with better early survival than standard hospital-based haemodialysis. Its use in Australia has been severely limited by poor outcomes compared to the rest of the world. This international study aims to identify “real world” PD centre practices that will lead to better outcomes for Australian patients, greater uptake of home dialysis and health savings of tens of millions of dollars annually.
Therapeutic Potential Of Peritoneal Mononuclear Phagocytes From Peritoneal Dialysis Patients
Funder
National Health and Medical Research Council
Funding Amount
$375,817.00
Summary
Mononuclear phagocytes (MP) are key cells which are now being used to treat various diseases. In Australia, more than 10 million end stage kidney disease(ESKD) patients are treated with chronic dialysis, and more than 20% of them are on peritoneal dialysis (PD). Each PD patient discards more than 20 million MP in dialysate daily. We will explore the possibility of using these MP to treat diseases including transplant rejection.
Macrophages: A Therapeutic Target In Peritoneal Dialysis-induced Fibrosis?
Funder
National Health and Medical Research Council
Funding Amount
$593,888.00
Summary
Fibrosis (scar tissue) in the abdominal cavity is a common side-effect of peritoneal dialysis (a treatment for kidney failure), and results in a life-threatening loss of dialysis function. The cells causing the fibrosis are uncertain. This project asks: Are inflammatory cells (macrophages) the source of peritoneal scar tissue? What regulates the fibrotic process? Answers may lead to strategies to prevent fibrosis induced by peritoneal dialysis, abdominal surgery or other causes.
To Investigate Rates Of Peritonitis In Incident Peritoneal Dialysis Patients In Australia And Perform A Pilot Study Aimed At Reducing These Rates
Funder
National Health and Medical Research Council
Funding Amount
$92,314.00
Summary
Overall aims: To establish how much variation in PD practice exists between renal units in Australia; to establish current practice in 8 units; to perform an intervention study in 8 units; to analyse registry data re peritonitis in PD patients; to conduct interviews with PD patients who have had peritonitis. Expected outcomes: To establish if practice variation is associated with peritonitis rates; to see if active guideline implementation leads to better peritonitis rates; to establish the reas ....Overall aims: To establish how much variation in PD practice exists between renal units in Australia; to establish current practice in 8 units; to perform an intervention study in 8 units; to analyse registry data re peritonitis in PD patients; to conduct interviews with PD patients who have had peritonitis. Expected outcomes: To establish if practice variation is associated with peritonitis rates; to see if active guideline implementation leads to better peritonitis rates; to establish the reasons why therapy fails.Read moreRead less
Foot Complications Associated With End-stage Renal Disease.
Funder
National Health and Medical Research Council
Funding Amount
$99,002.00
Summary
People with renal failure and diabetes have been found to be at a high risk for serious foot complications including; foot ulceration and amputation. Currently, there is limited research regarding the risk of developing these foot complications in people with renal failure, without the influence of diabetes. Therefore, this study aims to evaluate whether people with renal failure, without diabetes, are at risk for developing foot complications.
End Stage Kidney Disease In The Elderly: Understanding Patient-Centred Outcomes To Improve Delivery Of Renal Services
Funder
National Health and Medical Research Council
Funding Amount
$122,774.00
Summary
There are an increasing number of elderly Australians with kidney failure. Some of these people choose to have dialysis whilst others do not. There is little evidence on which to base this decision and a lack of dedicated services for patients who choose not to have dialysis. This research aims to understand the complete experience of older kidney failure patients by examining survival, quality of life, symptom burden, impact on carers and factors behind treatment decisions. It will also explore ....There are an increasing number of elderly Australians with kidney failure. Some of these people choose to have dialysis whilst others do not. There is little evidence on which to base this decision and a lack of dedicated services for patients who choose not to have dialysis. This research aims to understand the complete experience of older kidney failure patients by examining survival, quality of life, symptom burden, impact on carers and factors behind treatment decisions. It will also explore the effect of specialised services on outcomes.Read moreRead less