Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989703
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Multiphoton microscope for cellular imaging in live animals. The proposed facility will for the first time allow scientists across Sydney to monitor cell function in intact brain and muscle tissues. The novel optical approach combines fluorescent markers with sophisticated microscopy. The presence of this facility will allow Australian scientists to design new approaches to fundamental biological questions concerning cellular function within the normal environment. In addition this facility wi ....Multiphoton microscope for cellular imaging in live animals. The proposed facility will for the first time allow scientists across Sydney to monitor cell function in intact brain and muscle tissues. The novel optical approach combines fluorescent markers with sophisticated microscopy. The presence of this facility will allow Australian scientists to design new approaches to fundamental biological questions concerning cellular function within the normal environment. In addition this facility will allow PhD and post-doctoral scientists to train and have access to a rapidly developing and cutting edge approach to biological problems.Read moreRead less
NEU-HORIZONS: The Neuroprotection And Therapeutic Use Of Riluzole For The Prevention Of Oxaliplatin Neurotoxicity Study.
Funder
National Health and Medical Research Council
Funding Amount
$382,402.00
Summary
Colorectal cancer is the second most commonly diagnosed cancer in Australia, with more than 13500 cases recorded annually. Oxaliplatin is an effective chemotherapy for the treatment of colorectal cancer. The major side-effect of oxaliplatin is the development of nerve damage that leads to loss of feeling in the hands and feet and significant disability. The aim of this study is to conduct a trial of a new treatment for oxaliplatin-induced nerve damage.
A Wireless Electric Nerve-guide For Peripheral Nerve Repair
Funder
National Health and Medical Research Council
Funding Amount
$805,064.00
Summary
We aim to deliver a radical new precision intervention for peripheral nerve repair to improve the lives of people with peripheral nerve damage. Drawing from our recently awarded work on 'electric neural tissue engineering', we will pre-clinically test our invention of a unique clinically-amenable electric nerve-guide (e-nerve-guide), designed to act as a protective nerve conduit and wirelessly electrically-stimulate damaged nerves for their regeneration and restoration of function.
Anandamide activated chloride channels in sensory neurons. We are seeking to understand how the nerve cells that sense our environment are regulated by signalling molecules produced by our body. Understanding how these cells function in normal conditions is essential as basis for understanding how they may function abnormally in physically stressful situations or in chronic pain conditions. The work may eventually lead to better treatments for a wide range of disorders that involve the sensory ....Anandamide activated chloride channels in sensory neurons. We are seeking to understand how the nerve cells that sense our environment are regulated by signalling molecules produced by our body. Understanding how these cells function in normal conditions is essential as basis for understanding how they may function abnormally in physically stressful situations or in chronic pain conditions. The work may eventually lead to better treatments for a wide range of disorders that involve the sensory nervous system. Read moreRead less
The Final Common Channel: Measurement Of Nerve Excitability In Epilepsy.
Funder
National Health and Medical Research Council
Funding Amount
$301,376.00
Summary
Epilepsy may be due to either one single genetic mutation or a combination of several gene-environment interactions, affecting how ion channels function. It is not possible to directly interrogate channels in the living human brain but, because similar channels are found in peripheral nerve, much may be learned about aberrant channel function from peripheral nerve. This project aims to measure peripheral nerve excitability in epilepsy patients, using it as a marker of the final common pathway of ....Epilepsy may be due to either one single genetic mutation or a combination of several gene-environment interactions, affecting how ion channels function. It is not possible to directly interrogate channels in the living human brain but, because similar channels are found in peripheral nerve, much may be learned about aberrant channel function from peripheral nerve. This project aims to measure peripheral nerve excitability in epilepsy patients, using it as a marker of the final common pathway of channel dysfunction.Read moreRead less
The role of intracellular calcium in fibre-type specific gene expression in skeletal muscle. Muscles contain different fibre types whose composition can be changed by activity. The aim of this proposal is to identify the intracellular mechanisms which control fibre type. Our hypothesis is that different patterns of intracellular calcium determine the pattern of gene expression which determines fibre type. Understanding how gene expression is regulated is a central issue in biology.
Relationship of retinal directionality to human retinal anatomy variations. This project aims to improve measurement of retinal directionality, which is the reduction in brightness when a light beam’s entry into the human eye is shifted from the centre to the edge of the pupil. This influences retinal image quality and can be used to measure changes in shape of the peripheral eye. This project will apply advanced technologies in holography, and heads-up displays to explore how retinal directiona ....Relationship of retinal directionality to human retinal anatomy variations. This project aims to improve measurement of retinal directionality, which is the reduction in brightness when a light beam’s entry into the human eye is shifted from the centre to the edge of the pupil. This influences retinal image quality and can be used to measure changes in shape of the peripheral eye. This project will apply advanced technologies in holography, and heads-up displays to explore how retinal directionality changes during accommodation (focusing). The expected outcome is improved understanding of retinal stretching changes during focusing. The benefit is that the project will lead to advancements in retinal imaging.Read moreRead less
Removing the blinkers: a wider study of the human eye. Peripheral aberrations, wide-field retinal imaging and optical parameters. This project will study peripheral (side vision) optics of the human eye and its role in the limits of visual performance. This will improve ocular measurements and contribute towards improved diagnosis and treatment of ocular diseases and short-sightedness.
Advanced methods for intraocular imaging. The ability to image the retina of the human eye at high resolution is fundamental to improving understanding of ocular physiology, ocular optics and disease diagnosis. This project applies the relatively new application of active optics to vision science. This project will investigate the advantages of using new beam shaping techniques for characterising the optics of the eye, improving retinal imagery and improving fixation stability. This project will ....Advanced methods for intraocular imaging. The ability to image the retina of the human eye at high resolution is fundamental to improving understanding of ocular physiology, ocular optics and disease diagnosis. This project applies the relatively new application of active optics to vision science. This project will investigate the advantages of using new beam shaping techniques for characterising the optics of the eye, improving retinal imagery and improving fixation stability. This project will achieve three-dimensional holography of human eyes and develop holography plates for correcting the aberrations of eyes. Expected outcomes are not-before experienced resolution images of the retina and better understanding of the optical characteristics of the refractive surfaces and media in the eye.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100477
Funder
Australian Research Council
Funding Amount
$421,554.00
Summary
Advancing Human Perception: Countering Evolving Malicious Fake Visual Data. The aim of this project is to provide new effective and generalisable deepfake detection methods for automatically detecting maliciously manipulated visual data generated by misused artificial intelligence (AI) techniques. It will present innovative computer vision and image processing knowledge and techniques, enabling the developed methods to advance human perception in recognising fake data, enhance cybersecurity, and ....Advancing Human Perception: Countering Evolving Malicious Fake Visual Data. The aim of this project is to provide new effective and generalisable deepfake detection methods for automatically detecting maliciously manipulated visual data generated by misused artificial intelligence (AI) techniques. It will present innovative computer vision and image processing knowledge and techniques, enabling the developed methods to advance human perception in recognising fake data, enhance cybersecurity, and protect privacy in AI applications. The anticipated outcomes should provide significant benefits to a wide range of applications, such as providing timely alerts to the media, government organisations, and the industry about misleading fake visual data, and preventing financial crimes on synthetic identity fraud.Read moreRead less