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The Incidence And Predictors Of Foot Disease Hospitalisation
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Foot disease seems to be a much larger cause of hospitalisation than first thought. This research program aims to study for the first ever time the annual incidence of foot disease hospitalisation and develop models to predict which patients with foot disease are likely to be hospitalised or die. We believe this research will help clinicians, researchers and governments from around the world to measure, predict and prevent foot disease hospitalisation in their nations for the first time.
The Contribution Of IL-1 Signalling To Long-term Neurodegeneration, Epilepsy And Neurocognitive Outcomes Following Traumatic Injury To The Paediatric Brain
Funder
National Health and Medical Research Council
Funding Amount
$394,670.00
Summary
Epilepsy is a common, debilitating consequence of brain injury in children, however little is known about factors which trigger its development. This proposal investigates the contribution of the acute inflammatory response to long-term neuronal loss, functional outcomes and seizure activity after paediatric brain injury. Understanding how epilepsy and brain damage progresses after injury will aid the development of drugs to improve long-term outcomes in brain-injured children.
Optic Nerve Head Structure And Genetic/environmental Associations: A Population-based SD-OCT Study
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
My research project combines two powerful new technologies, spectral domain-optical coherence tomography and the genome-wide association study, to investigate the physical and genetic characteristics of the optic nerve head in humans. Results from this work will help identify new glaucoma risk genes, increasing sensitivity and specificity for predicting glaucoma and expand our understanding of the disease mechanism allowing for the development of new treatments.
The Role Of Gastric Vagal Afferents In The Food Intake Reducing Effect Of Oestradiol
Funder
National Health and Medical Research Council
Funding Amount
$317,739.00
Summary
Regulation of food intake is paramount for maintaining health. Nerves from the stomach serve as important regulators of food intake. These nerves can be modulated by chemical substances; however the importance of this modulation is not well defined. The sex steroid, oestradiol, has potent food intake reducing effects, but the mechanism for this is poorly understood. Thus, this fellowship will examine the role that oestradiol has in regulating food intake by acting on nerves within the stomach.
The Role Of The Systemic Milieu In Preventing Motor Unit Remodelling And Loss During Ageing
Funder
National Health and Medical Research Council
Summary
Motor unit remodeling and loss contributes to the decline in muscle mass, strength and quality of life in our aging population. Recent data shows that exposing aged mice to 'blood-borne factors' from the circulation of a young mouse can reverse the age-associated deficits in motor unit structure and function. A better understanding of the factors controlling these anti-aging effects will be vital for finding new compounds to reverse the aging process and improve quality of life.