Acoustic loads on hypersonic engines. This project aims to understand how acoustic loads are generated in supersonic combustion ramjets (scramjets) to control sonic fatigue in reusable hypersonic vehicles. This knowledge could make space access affordable. This project will measure acoustic waves in scramjets. The anticipated discoveries will enable reusable, hypersonic vehicles to be used for space launch systems and high-speed aircraft. These systems will dramatically reduce the cost of space ....Acoustic loads on hypersonic engines. This project aims to understand how acoustic loads are generated in supersonic combustion ramjets (scramjets) to control sonic fatigue in reusable hypersonic vehicles. This knowledge could make space access affordable. This project will measure acoustic waves in scramjets. The anticipated discoveries will enable reusable, hypersonic vehicles to be used for space launch systems and high-speed aircraft. These systems will dramatically reduce the cost of space launch and global travel times. Expected benefits include reduced cost for access to space and the ability to design and develop advanced aerospace technology.Read moreRead less
A Sequential Multiple Assignment Randomised Trial (SMART) Of Nursing Interventions To Reduce Pain Associated With Chemotherapy Induced Peripheral Neuropathy
Funder
National Health and Medical Research Council
Funding Amount
$713,418.00
Summary
Modern chemotherapy treatments can result in damage to the peripheral nerves, resulting in a condition called peripheral neuropathy. This condition is characterised by a range of sensory and functional changes that can cause pain and reduced ability to perform daily activities. This project will test various non-pharmacological pain management measures to determine if they are effective in improving the quality of life of patients who experience this problem.
Novel Applied Bayesian Statistics for Monitoring Neuromuscular Diseases. Neurological diseases such as motor neurone disease are caused by the progressive death of motor units serving a muscle. Currently there are no ways of quantifying and detecting change in the number of motor units serving a muscle which are non-invasive. Our research will provide an objective method for the progression of neuromuscular diseases to be monitored with minimal inconvenience to patients. This will allow clinic ....Novel Applied Bayesian Statistics for Monitoring Neuromuscular Diseases. Neurological diseases such as motor neurone disease are caused by the progressive death of motor units serving a muscle. Currently there are no ways of quantifying and detecting change in the number of motor units serving a muscle which are non-invasive. Our research will provide an objective method for the progression of neuromuscular diseases to be monitored with minimal inconvenience to patients. This will allow clinical trials for possible effective treatments of neurological diseases such as motor neurone disease to be conducted with an objective measurement of disease progression. Read moreRead less
Sustaining neuronal communication through bulk endocytosis. Brain activities such as learning and memory rely on the ability of neurons to communicate. This research will improve our understanding of how synaptic vesicles recycle during periods of intense synaptic activity. This is a fundamental process relevant to neuronal communication, insulin release, hormone secretion, and allergic responses in health and disease and therefore has broad significance. This work will enhance Australia's exist ....Sustaining neuronal communication through bulk endocytosis. Brain activities such as learning and memory rely on the ability of neurons to communicate. This research will improve our understanding of how synaptic vesicles recycle during periods of intense synaptic activity. This is a fundamental process relevant to neuronal communication, insulin release, hormone secretion, and allergic responses in health and disease and therefore has broad significance. This work will enhance Australia's existing strength in cell biology and neuroscience and provide high quality training for an undergraduate student and post-doctoral scientist.Read moreRead less
Membrane excitability and cellular calcium regulation in the peripheral nervous system under different (patho)-physiological conditions and in inflammatory disease. Studies of cytokine action on neurons and muscle give new insights into functional responses of the nervous system to systemic inflammation and sepsis. In some countries, sepsis is the third most frequent cause of death following heart attack. Elucidating the pathomechanisms allows to develop therapeutic strategies. Electrophysiology ....Membrane excitability and cellular calcium regulation in the peripheral nervous system under different (patho)-physiological conditions and in inflammatory disease. Studies of cytokine action on neurons and muscle give new insights into functional responses of the nervous system to systemic inflammation and sepsis. In some countries, sepsis is the third most frequent cause of death following heart attack. Elucidating the pathomechanisms allows to develop therapeutic strategies. Electrophysiology, Ca2+ regulation and optical membrane potentiometry allow us to monitor early changes in disease on a (sub)cellular level. Experiments on Ca2+ regulation and ion channel function in muscle with different cholesterol membrane contents will help to understand pathomechanisms in high cholesterol diseases, e.g. obesity, on the membrane level long before cardiovascular effects become prominent.Read moreRead less
Offsite manufacture reimagined for high-performance adaptable housing. The project aims to address housing performance and affordability in Australia by deploying adaptable design for spatial reconfiguration and component reuse, to advance offsite timber manufacture towards energy efficient and healthy homes as mainstream practice. The intended outcome is the development, prototyping and monitoring of an offsite manufactured panelised lightweight timber system for high-performance homes, that is ....Offsite manufacture reimagined for high-performance adaptable housing. The project aims to address housing performance and affordability in Australia by deploying adaptable design for spatial reconfiguration and component reuse, to advance offsite timber manufacture towards energy efficient and healthy homes as mainstream practice. The intended outcome is the development, prototyping and monitoring of an offsite manufactured panelised lightweight timber system for high-performance homes, that is adaptable to all Australian climates and long-term household changes. This will contribute to the sustainable growth of the Australian housing market with significant benefits on housing affordability, adaptable design and long-lasting performance, while boosting the offsite manufactured timber construction sector.Read moreRead less
Designing offices well. This project aims to describe, quantify and analyse the impact of workspace design on workers’ satisfaction, productivity and health. The Australian market is the fastest adopter of Activity-Based Working (ABW) in the world and impacts arising from this workspace typology on workers will be significant now and in the next decade. This project will develop benchmarking for ABW offices, techniques for monitoring cognitive performance in situ, and design guidelines for healt ....Designing offices well. This project aims to describe, quantify and analyse the impact of workspace design on workers’ satisfaction, productivity and health. The Australian market is the fastest adopter of Activity-Based Working (ABW) in the world and impacts arising from this workspace typology on workers will be significant now and in the next decade. This project will develop benchmarking for ABW offices, techniques for monitoring cognitive performance in situ, and design guidelines for health promotion. By shifting attention to design features that actually perform well, this project will provide the empirical basis needed to transform the way workspaces are designed now and in the future. It will therefore lead to greater productivity in and among workplaces.Read moreRead less
Using toxins to understand the mechanisms of pain. Toxins have evolved in plants, animals and microbes as part of defensive and/or prey capture strategies, and have proven to be invaluable research tools as well as providing leads for potential new therapies. This project will use subtype-selective toxins to define the role of ion channels in pain, using novel pathway-specific and disease-specific animal models of pain. The findings from this project will provide significant insight into the ne ....Using toxins to understand the mechanisms of pain. Toxins have evolved in plants, animals and microbes as part of defensive and/or prey capture strategies, and have proven to be invaluable research tools as well as providing leads for potential new therapies. This project will use subtype-selective toxins to define the role of ion channels in pain, using novel pathway-specific and disease-specific animal models of pain. The findings from this project will provide significant insight into the neuropharmacology of pain, will lead to the identification of novel molecular targets with analgesic potential and is expected to provide novel treatment approaches for pain.Read moreRead less
Designing healthy and efficient luminous environments in Green Buildings. This project aims to investigate the relationship between indoor lighting, visual comfort, and office workers’ wellbeing for green buildings in Australia. Around 50 per cent of workers in green commercial buildings in subtropical climates have reported visual discomfort from glass facades and light-emitting diodes (LEDs). Visual discomfort could affect people’s performance. It could also increase energy consumption due to ....Designing healthy and efficient luminous environments in Green Buildings. This project aims to investigate the relationship between indoor lighting, visual comfort, and office workers’ wellbeing for green buildings in Australia. Around 50 per cent of workers in green commercial buildings in subtropical climates have reported visual discomfort from glass facades and light-emitting diodes (LEDs). Visual discomfort could affect people’s performance. It could also increase energy consumption due to users’ interventions, causing a clear mismatch between design intent and final results. The project aims to relate the luminous environment to occupant responses and to use a novel tool for capturing physical and psychological properties of luminous environments through smart phones. The outcome should be a predictive model of visual comfort for better design of buildings.Read moreRead less