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Roles Of PTHrP And Calcium In Mammary Function In Perinatal Growth Restriction
Funder
National Health and Medical Research Council
Funding Amount
$376,320.00
Summary
Babies that are born small have significant problems around the time of birth and may have limited catch-up growth. A recently discovered protein known as PTHrP influences the nutrition of the growing newborn through breast milk. Because of its potential importance to small babies we intend to study this protein during and after pregnancy in rats and their pups. New treatments may emerge from the knowledge gained from these studies that may improve the growth and health of infants.
A Risk Stratification Tool For The Prevention Of Avoidable Perinatal Mortality And Morbidity
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Stillbirth is more common in Australia than in some high-income countries. Babies born early may experience lung or other problems. Many current stillbirths and preterm birth can be prevented. Using a cohort of >4.5 million births from WA, NSW, SA and NT (N >4.5 million), this project will develop a strategy to predict the risk of stillbirth, preterm birth, and low birth weight. Better identification of risk in pregnancy will improve antenatal care to reduce stillbirth and neonatal morbidi ....Stillbirth is more common in Australia than in some high-income countries. Babies born early may experience lung or other problems. Many current stillbirths and preterm birth can be prevented. Using a cohort of >4.5 million births from WA, NSW, SA and NT (N >4.5 million), this project will develop a strategy to predict the risk of stillbirth, preterm birth, and low birth weight. Better identification of risk in pregnancy will improve antenatal care to reduce stillbirth and neonatal morbidity.Read moreRead less
Identifying Mechanisms Underlying Ethnic Inequalities In Birth Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$316,893.00
Summary
There are significant ethnic inequalities in birth outcomes in Australia however the mechanisms underlying the relationships are unclear. This is important to investigate if improvements in outcomes for all women and babies are to be achieved. This study will identify potential mechanisms underlying the ethnic inequalities in Victoria. This work will inform clinical practice guidelines with the goal of improving health outcomes for women and their babies from different ethnic groups.
Healthy Futures For Vulnerable Families: Addressing Inequalities In Maternal And Child Health Care For Refugee And Aboriginal Families
Funder
National Health and Medical Research Council
Funding Amount
$421,747.00
Summary
This proposal will help to determine organisational and service level factors leading to better health outcomes for Aboriginal and refugee women and their families during and after pregnancy; and develop and test interventions to reform maternity and early childhood health systems to reduce maternal and child health inequalities for vulnerable populations.
Sleep And Motherhood: Towards A Sustainable Cognitive Behavioural Program For Better Sleep And Wellbeing During Pregnancy And Postpartum Periods.
Funder
National Health and Medical Research Council
Funding Amount
$286,891.00
Summary
Sleep problems are common during pregnancy and postpartum periods, and are linked to poor maternal mental health and wellbeing. Cognitive behavioural sleep interventions are effective, but not currently available in routine perinatal care. This study examines the efficacy of an innovative evidence-based non-pharmacological intervention for better sleep and wellbeing, with high potential for sustainable integration with routine perinatal care.
Optimising Asthma Management In Pregnancy For Optimal Infant Health
Funder
National Health and Medical Research Council
Funding Amount
$428,065.00
Summary
Asthma affects 12% of pregnant women in Australia. These women are at increased risk of poor pregnancy outcomes, such as preterm birth and hospitalisation of the neonate. Reducing asthma attacks by providing optimal asthma management during pregnancy may lower these risks. This research will test whether a strategy which determines treatment changes based on a marker of airway inflammation, improves outcomes for maternal, neonatal and child health.
Preterm Birth And Exposure To Fine Particulate Matter
Funder
National Health and Medical Research Council
Funding Amount
$341,068.00
Summary
Preterm birth is the single most important cause of perinatal mortality and leading cause of subsequent morbidity in the western world. This project involves an investigation of the effects of fine airborne particulates and their chemical constituents on preterm birth among half a million pregnant women in Australia and the US. Levels of particulates will be rigorously assessed using traditional methods such as chemical analyses of field samples and novel methods such as processing satellite ima ....Preterm birth is the single most important cause of perinatal mortality and leading cause of subsequent morbidity in the western world. This project involves an investigation of the effects of fine airborne particulates and their chemical constituents on preterm birth among half a million pregnant women in Australia and the US. Levels of particulates will be rigorously assessed using traditional methods such as chemical analyses of field samples and novel methods such as processing satellite imagery.Read moreRead less
Is Infection An Acute Trigger For Preeclampsia? A Case-crossover Study.
Funder
National Health and Medical Research Council
Funding Amount
$207,761.00
Summary
Preeclampsia is a multisystem hypertensive disease affecting up to 10% of pregnancies. It puts both mother and baby at increased risk of major illness and death. The cause is unknown but inflammation appears to play a key role. We will use an innovative design to determine whether recent maternal infection triggers the onset of preeclampsia. If preeclampsia is associated with infection, preventative strategies can be developed.
My Baby's Movements: A Stepped Wedged Cluster Randomised Trial Of Maternal Awareness And Reporting Of Decreased Fetal Movements To Reduce Stillbirth
Funder
National Health and Medical Research Council
Funding Amount
$1,431,444.00
Summary
Stillbirth is devastating for parents and families. Many stillbirths occur late in pregnancy due to deteriorating health of the baby that can be detected by the mother through a decrease in the baby’s movements. 'My Baby's Movements’ is a personalised, user-controlled and interactive mobile phone tool provided as part of routine care to pregnant women to promote general awareness of their baby’s movements. This trial aims to reduce stillbirth rates by early reporting of decreased movements.