Prediction of tissue fate and functional outcome in acute ischemic stroke with advanced imaging analysis - experimental validation and translational studies. Stroke is predominantly a disease of ageing and the commonest cause of adult disability. In Australia, 55,000 people have a stroke each year (>80% are over age 65). The total number of strokes per year worldwide will rise 60% within the next two decades as the proportion of elderly in our population increases. This research will improve bra ....Prediction of tissue fate and functional outcome in acute ischemic stroke with advanced imaging analysis - experimental validation and translational studies. Stroke is predominantly a disease of ageing and the commonest cause of adult disability. In Australia, 55,000 people have a stroke each year (>80% are over age 65). The total number of strokes per year worldwide will rise 60% within the next two decades as the proportion of elderly in our population increases. This research will improve brain imaging selection for acute stroke therapies in clinical trials and practice. Better acute stroke therapies limit the size of brain damage from stroke and reduce long-term disability. Thus, this research will directly translate into allowing our population to 'age well and productively'.Read moreRead less
The early osteoarthritis (OA) phenotype. Australia like many other developed countries is undergoing a major demographic shift involving significant growth in the aged population. From both a patient perspective and a societal perspective, research into the underlying determinants of osteoarthritis such as those outlined in this proposal are of great importance to the aged population. Nearly one in five Australians has arthritis; indeed more Australians have arthritis than any other national hea ....The early osteoarthritis (OA) phenotype. Australia like many other developed countries is undergoing a major demographic shift involving significant growth in the aged population. From both a patient perspective and a societal perspective, research into the underlying determinants of osteoarthritis such as those outlined in this proposal are of great importance to the aged population. Nearly one in five Australians has arthritis; indeed more Australians have arthritis than any other national health priority condition. From an individual point-of-view, the pain and disability due to osteoarthritis (OA) can lead to loss of independence and diminished in quality of life for older adults.Read moreRead less
Development of Novel Two-dimensional Techniques for Magnetic Resonance In-vivo Spectroscopy. Body chemistry alters with functionality, pain, ageing and disease. These changes can be recorded by magnetic resonance (MR) spectroscopy (MRS) in vivo in a whole body MR scanner. When changes in chemistry can be recorded rapidly, and the individual species assigned, it will be possible to make a definitive diagnosis and in some cases allow the tailoring of treatment on an individual basis. This is curre ....Development of Novel Two-dimensional Techniques for Magnetic Resonance In-vivo Spectroscopy. Body chemistry alters with functionality, pain, ageing and disease. These changes can be recorded by magnetic resonance (MR) spectroscopy (MRS) in vivo in a whole body MR scanner. When changes in chemistry can be recorded rapidly, and the individual species assigned, it will be possible to make a definitive diagnosis and in some cases allow the tailoring of treatment on an individual basis. This is currently hampered by our inability to separate the composite resonances in a one dimensional MR spectrum. Research will allow two dimensional MRS to be implemented and provide detailed chemical information on human organs in vivo. Read moreRead less
Quantifying cortical thickness and white matter hyperintensity volumes and determining their relationship on Magnetic Resonance Imaging in ageing brains. Australia's population is ageing, with a significant projected increase in the number of people aged over 65 and 85. Mental health and quality of life for this ageing population have become an increasingly important issue. This project directly addresses the National Research Priority 2 in the terms of ageing well, ageing productively. Accurat ....Quantifying cortical thickness and white matter hyperintensity volumes and determining their relationship on Magnetic Resonance Imaging in ageing brains. Australia's population is ageing, with a significant projected increase in the number of people aged over 65 and 85. Mental health and quality of life for this ageing population have become an increasingly important issue. This project directly addresses the National Research Priority 2 in the terms of ageing well, ageing productively. Accurately measuring the distribution of brain structural changes is an effective way of differentiating normal ageing from various pathological conditions reflecting the underlying pathology. The project has access to an unprecedented large sample of longitudinal Magnetic Resonance Imaging and health/clinical data and will produce a set of algorithms to examine this issue and put Australia at the forefront of such research.Read moreRead less