The Role Of A New Class Of Chromatin Organising Hub
Funder
National Health and Medical Research Council
Funding Amount
$1,145,450.00
Summary
Within the cell nucleus, specific proteins weave DNA into structured loops that are vital for normal cell function. By studying the molecules involved, we have uncovered a ‘dock’ that controls this DNA architecture. We will define the components and function of this ‘dock’, and the resulting rapid cell death that occurs if it is disrupted. We will explore this cell death pathway thoroughly because we think it may help us to develop new cancer therapies.
Molecular And Structural Basis Of Signalling By TIR Domain-containing Adaptors In TLR Pathways
Funder
National Health and Medical Research Council
Funding Amount
$666,417.00
Summary
Humans first detect the presence of pathogens and respond to them through specific pathways termed innate immune pathways. The proposed research will study proteins that participate in these pathways, in particular their three-dimensional structures and how they interact with each other, to understand how they work together to mount an immune response, and to find ways to modulate this response in infectious diseases as well as chronic inflammatory diseases.
This project will unleash the potential of peptide drugs by overcoming their final barrier to widespread use, their synthesis. Plants naturally produce ultra-stable cyclic peptides. We will co-opt their machinery to produce in seeds, two drug leads that have potential as treatments for prostate cancer and chronic neuropathic pain. As an �organic� drug source, seeds have the potential to improve patient compliance and low-tech production systems will allow technology transfer to third-world natio ....This project will unleash the potential of peptide drugs by overcoming their final barrier to widespread use, their synthesis. Plants naturally produce ultra-stable cyclic peptides. We will co-opt their machinery to produce in seeds, two drug leads that have potential as treatments for prostate cancer and chronic neuropathic pain. As an �organic� drug source, seeds have the potential to improve patient compliance and low-tech production systems will allow technology transfer to third-world nations.Read moreRead less