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DYRK1A As A Novel Target For Glioblastoma Therapies
Funder
National Health and Medical Research Council
Funding Amount
$620,294.00
Summary
Glioblastoma is a form of brain cancer that is currently incurable. We have discovered that switching-off an enzyme called DYRK1A (using ‘DYRK1A inhibitors’) kills glioblastoma cells. This therapeutic advantage is even greater when combined with drugs approved for other cancers. This project will develop new DYRK1A inhibitors and examine a novel combination treatment for glioblastoma patients. This could initiate a novel therapy that could significantly extend patients’ lives.
Antigen Selection In The MHC-restricted Cellular Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$175,570.00
Summary
The body's white cells eliminate microorganisms through the actions of immune lymphocytes and other cells which conspire to kill and neutralise these unwanted guests. When microorganisms hide inside the cells of the body they are still detected by a set of T lymphocytes which have specific receptors for scrutinising the surface of cells for any changes which might signal an intracellular infection. The immune system is ever vigilant in its search for signs of infection which are generally appare ....The body's white cells eliminate microorganisms through the actions of immune lymphocytes and other cells which conspire to kill and neutralise these unwanted guests. When microorganisms hide inside the cells of the body they are still detected by a set of T lymphocytes which have specific receptors for scrutinising the surface of cells for any changes which might signal an intracellular infection. The immune system is ever vigilant in its search for signs of infection which are generally apparent when molecules called antigens are released by microorganisms and captured by the body's cells. This activates lymphocytes resulting in an immune response capable of eliminating the microorganisms. Scrutiny of the body's cells by lymphocytes occurs continuously even when there is no infection present in the body. Following infection of a cell, microbial antigens reveal the infection by their appearance on the cell surface where they are detected by the immune system's lymphocytes. This occurs through a mechanism called antigen presentation. During antigen presentation the proteins inside the cell, including those of any invading microorganism, are first degraded into shorter molecules called peptides. This event is called antigen processing. A fraction of the peptides created by antigen processing are captured by specialised receptors present on all cells. These receptors are called HLA or histocompatibility molecules. This project examines the molecular events which mediate the capture of peptide antigens by HLA molecules. The main focus is on those peptide antigens which elicit killer T cell responses by the immune system. A knowledge of how these peptides are selected for presentation and how they are captured and carried to the cell surface is fundamental to understanding immune responses to microorganisms, tumours, allergens, transplants and self tissues as in autoimmunity. Therefore the study is of great general relevance.Read moreRead less
Multiliteracies for addressing disadvantage in senior school science. Multiliteracies for addressing disadvantage in senior school science. This project aims to develop discipline-specific pedagogies in senior physics, chemistry and biology to improve disadvantaged students’ engagement and achievement. Many students from disadvantaged backgrounds fail to develop the linguistic precision and symbolic representational dexterity needed to comprehend and communicate senior school science concepts. T ....Multiliteracies for addressing disadvantage in senior school science. Multiliteracies for addressing disadvantage in senior school science. This project aims to develop discipline-specific pedagogies in senior physics, chemistry and biology to improve disadvantaged students’ engagement and achievement. Many students from disadvantaged backgrounds fail to develop the linguistic precision and symbolic representational dexterity needed to comprehend and communicate senior school science concepts. These pedagogies will ‘infuse’ multiliteracies in senior school science to improve access to science-based pathways for these students, and enable them to understand progressively more complex scientific concepts and demonstrate this in examinations. This project is expected to improve student retention, arrest declining enrolments in senior school science, and increase young people working in science.Read moreRead less
Genetic rescue of Australian wildlife. Genetic rescue of Australian wildlife. This project aims to test genetic rescue as an efficient recovery technique for threatened plants and animals. Genetic rescue is under-utilised, even though it is overwhelmingly beneficial. This project will convert management actions on five Endangered/Critically Endangered species into rigorous experiments that measure the fitness benefits of genetic rescue, and demonstrate genome-wide consequences. Anticipated outco ....Genetic rescue of Australian wildlife. Genetic rescue of Australian wildlife. This project aims to test genetic rescue as an efficient recovery technique for threatened plants and animals. Genetic rescue is under-utilised, even though it is overwhelmingly beneficial. This project will convert management actions on five Endangered/Critically Endangered species into rigorous experiments that measure the fitness benefits of genetic rescue, and demonstrate genome-wide consequences. Anticipated outcomes include innovative genetic rescue protocols, a framework for genetic rescue, and leading-edge conservation training. Expected benefits are increased persistence of species that are otherwise unresponsive to management, and a new path to saving endangered species.Read moreRead less
Fine Tuning: A Reconciliation of Indigenous and Western Musical Traditions. Focusing on central Australian song lines, the project strengthens our knowledge, understanding and application of the intricate tuning systems that underpin traditional Indigenous musical practices. Employing a unique methodology that combines Indigenous and contemporary Western musical performance practices with cutting-edge digital technologies, the project will show how the highly nuanced and sophisticated tunings at ....Fine Tuning: A Reconciliation of Indigenous and Western Musical Traditions. Focusing on central Australian song lines, the project strengthens our knowledge, understanding and application of the intricate tuning systems that underpin traditional Indigenous musical practices. Employing a unique methodology that combines Indigenous and contemporary Western musical performance practices with cutting-edge digital technologies, the project will show how the highly nuanced and sophisticated tunings at the heart of Indigenous music-making can be preserved when transposed to contemporary Western art music contexts. In so doing, the case is made for a more genuine, equitable dialogue between Indigenous and non-Indigenous music-makers, to the mutual benefit of musicians, audiences, and society at large. Read moreRead less
Linking for Life: Enhancing pathways to well-being for all Australians. The Linking for Life Project will identify pathways to wellbeing and better social outcomes across the life-course for high-risk/vulnerable individuals and their families to streamline service provision, improve outcomes and identify cost-efficiencies across government agencies. The work will expand cross-sectoral data linkage capability, enhancing research capacity to generate evidence-based policy to improve integrated ser ....Linking for Life: Enhancing pathways to well-being for all Australians. The Linking for Life Project will identify pathways to wellbeing and better social outcomes across the life-course for high-risk/vulnerable individuals and their families to streamline service provision, improve outcomes and identify cost-efficiencies across government agencies. The work will expand cross-sectoral data linkage capability, enhancing research capacity to generate evidence-based policy to improve integrated service delivery across government. The project will also trial innovative data linkage models including the creation of data repositories to improve efficiency for data provision and access, which will have application nationally and enable more timely access to whole-population linked cross-sector data.Read moreRead less
Exposure to workplace hazards among migrant workers in Australia. This project aims to compare the prevalence of exposure to workplace hazards, namely carcinogens and psychosocial risk factors (eg bullying and precarious work), among migrant and Australian-born workers. The international literature suggests that migrant workers are exposed to more workplace hazards than native-born populations, but the evidence base for Australia is patchy despite the fact that Australia has such a large migrant ....Exposure to workplace hazards among migrant workers in Australia. This project aims to compare the prevalence of exposure to workplace hazards, namely carcinogens and psychosocial risk factors (eg bullying and precarious work), among migrant and Australian-born workers. The international literature suggests that migrant workers are exposed to more workplace hazards than native-born populations, but the evidence base for Australia is patchy despite the fact that Australia has such a large migrant population. The anticipated goal of this project is to address this gap in evidence. The intended outcomes are the necessary first step in the process of reducing exposure to harmful substances and behaviours for all workers.Read moreRead less
Investigating literary knowledge in the making of English teachers. This project aims to create new understanding of the role of literary knowledge within subject English. English education is mandated in Australian schooling; however, subject content as well as teachers’ knowledge and pedagogical approaches are highly contested, particularly regarding the teaching of literature. Using a national survey, focus group interviews and a longitudinal study, the project aims to provide new understandi ....Investigating literary knowledge in the making of English teachers. This project aims to create new understanding of the role of literary knowledge within subject English. English education is mandated in Australian schooling; however, subject content as well as teachers’ knowledge and pedagogical approaches are highly contested, particularly regarding the teaching of literature. Using a national survey, focus group interviews and a longitudinal study, the project aims to provide new understandings of the literary knowledge that early career teachers need, of the impact of curricula and professional practice on disciplinary knowledge, and about the operation of literary studies across school and university. Significantly, it plans to use ‘literary sociability’, an innovative methodology, to generate empirical and conceptual perspectives on literary studies in Australia that will be of value internationally.Read moreRead less
Towards the health care system of the future: The role of institutional entrepreneurship in service redesign and innovation. The reform of healthcare systems presents one of the most pressing and fundamental challenges for nations such as Australia. To date, hospital redesign and innovation initiatives have had limited impacts and outcomes at a system level with improvements limited to discrete areas. The aim of this inter-disciplinary research is to promote the scaling up of such initiatives to ....Towards the health care system of the future: The role of institutional entrepreneurship in service redesign and innovation. The reform of healthcare systems presents one of the most pressing and fundamental challenges for nations such as Australia. To date, hospital redesign and innovation initiatives have had limited impacts and outcomes at a system level with improvements limited to discrete areas. The aim of this inter-disciplinary research is to promote the scaling up of such initiatives to have systems-wide outcomes. The research aims to address institutional constraints and organisational factors and will develop practical frameworks, processes and resources. These intend to enable hospitals to develop organisational and leadership capacities to ensure investments in redesign and innovation have ‘whole system’ economic and healthcare benefits.Read moreRead less
Optimal management of threatened amphibian metapopulations in urbanising landscapes. This project will enable the identification of optimal management strategies for many species threatened by the loss and fragmentation of their habitat, both in Australia and internationally. Our research will contribute to the recovery of the endangered Growling Grass Frog, and drive the conservation of wetland biodiversity on the fringe of Australia's fastest growing city. Both the methods and specific recomme ....Optimal management of threatened amphibian metapopulations in urbanising landscapes. This project will enable the identification of optimal management strategies for many species threatened by the loss and fragmentation of their habitat, both in Australia and internationally. Our research will contribute to the recovery of the endangered Growling Grass Frog, and drive the conservation of wetland biodiversity on the fringe of Australia's fastest growing city. Both the methods and specific recommendations for management that we develop will contribute to the goal of an environmentally-sustainable Australia. This project will expand Australia's capacity to solve conservation problems, and will promote biological diversity in urban environments, to the benefit of their human inhabitants.Read moreRead less