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DYRK1A As A Novel Target For Glioblastoma Therapies
Funder
National Health and Medical Research Council
Funding Amount
$620,294.00
Summary
Glioblastoma is a form of brain cancer that is currently incurable. We have discovered that switching-off an enzyme called DYRK1A (using ‘DYRK1A inhibitors’) kills glioblastoma cells. This therapeutic advantage is even greater when combined with drugs approved for other cancers. This project will develop new DYRK1A inhibitors and examine a novel combination treatment for glioblastoma patients. This could initiate a novel therapy that could significantly extend patients’ lives.
Antigen Selection In The MHC-restricted Cellular Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$175,570.00
Summary
The body's white cells eliminate microorganisms through the actions of immune lymphocytes and other cells which conspire to kill and neutralise these unwanted guests. When microorganisms hide inside the cells of the body they are still detected by a set of T lymphocytes which have specific receptors for scrutinising the surface of cells for any changes which might signal an intracellular infection. The immune system is ever vigilant in its search for signs of infection which are generally appare ....The body's white cells eliminate microorganisms through the actions of immune lymphocytes and other cells which conspire to kill and neutralise these unwanted guests. When microorganisms hide inside the cells of the body they are still detected by a set of T lymphocytes which have specific receptors for scrutinising the surface of cells for any changes which might signal an intracellular infection. The immune system is ever vigilant in its search for signs of infection which are generally apparent when molecules called antigens are released by microorganisms and captured by the body's cells. This activates lymphocytes resulting in an immune response capable of eliminating the microorganisms. Scrutiny of the body's cells by lymphocytes occurs continuously even when there is no infection present in the body. Following infection of a cell, microbial antigens reveal the infection by their appearance on the cell surface where they are detected by the immune system's lymphocytes. This occurs through a mechanism called antigen presentation. During antigen presentation the proteins inside the cell, including those of any invading microorganism, are first degraded into shorter molecules called peptides. This event is called antigen processing. A fraction of the peptides created by antigen processing are captured by specialised receptors present on all cells. These receptors are called HLA or histocompatibility molecules. This project examines the molecular events which mediate the capture of peptide antigens by HLA molecules. The main focus is on those peptide antigens which elicit killer T cell responses by the immune system. A knowledge of how these peptides are selected for presentation and how they are captured and carried to the cell surface is fundamental to understanding immune responses to microorganisms, tumours, allergens, transplants and self tissues as in autoimmunity. Therefore the study is of great general relevance.Read moreRead less
Multiliteracies for addressing disadvantage in senior school science. Multiliteracies for addressing disadvantage in senior school science. This project aims to develop discipline-specific pedagogies in senior physics, chemistry and biology to improve disadvantaged students’ engagement and achievement. Many students from disadvantaged backgrounds fail to develop the linguistic precision and symbolic representational dexterity needed to comprehend and communicate senior school science concepts. T ....Multiliteracies for addressing disadvantage in senior school science. Multiliteracies for addressing disadvantage in senior school science. This project aims to develop discipline-specific pedagogies in senior physics, chemistry and biology to improve disadvantaged students’ engagement and achievement. Many students from disadvantaged backgrounds fail to develop the linguistic precision and symbolic representational dexterity needed to comprehend and communicate senior school science concepts. These pedagogies will ‘infuse’ multiliteracies in senior school science to improve access to science-based pathways for these students, and enable them to understand progressively more complex scientific concepts and demonstrate this in examinations. This project is expected to improve student retention, arrest declining enrolments in senior school science, and increase young people working in science.Read moreRead less
Using immersive virtual reality to enhance students’ science visualisation. This project aims to investigate the potential of advanced visualisation technology, immersive virtual reality, as a collaborative learning environment to support students to explore their ideas and learn a core chemistry concept, molecular structures and functions. Incorporating both data analytics and qualitative video analysis, the project will establish a deep understanding of how students learn about the molecular w ....Using immersive virtual reality to enhance students’ science visualisation. This project aims to investigate the potential of advanced visualisation technology, immersive virtual reality, as a collaborative learning environment to support students to explore their ideas and learn a core chemistry concept, molecular structures and functions. Incorporating both data analytics and qualitative video analysis, the project will establish a deep understanding of how students learn about the molecular world within an immersive virtual reality environment in relation to the learners’ experience, chemistry content, visual representations, learning tasks, and design features. The project will recommend evidence-driven design considerations for learning resources development and further educational research with advanced technologies.Read moreRead less
The online future of Science and Engineering education: The essential elements of laboratory-based learning for remote-access implementation. Laboratory classes are a critical part of science and engineering degree programs, but there has been little research into what actually takes place within them. Remote laboratories, in which students control equipment via the internet, are one potential solution for accommodating rising numbers of students, but the interfaces must be developed to effectiv ....The online future of Science and Engineering education: The essential elements of laboratory-based learning for remote-access implementation. Laboratory classes are a critical part of science and engineering degree programs, but there has been little research into what actually takes place within them. Remote laboratories, in which students control equipment via the internet, are one potential solution for accommodating rising numbers of students, but the interfaces must be developed to effectively support student learning. This project will investigate how students interact with equipment, each other, and with laboratory demonstrators in order to determine the crucial components of effective laboratory learning experiences. It will identify and characterise the interactions of students in laboratory classes, and develop mechanisms to support these interactions remotely.Read moreRead less
Engaging Students during the Early Years of Secondary School. This project aims to design, test and share sustainable strategies to support teachers and enable students from low socioeconomic communities to achieve success. The greatest decreases in students’ interest and effort occur when they transition into secondary school, with students from low socioeconomic communities at greatest risk of disengagement. What can teachers do to engage their students during this key life transition? This pr ....Engaging Students during the Early Years of Secondary School. This project aims to design, test and share sustainable strategies to support teachers and enable students from low socioeconomic communities to achieve success. The greatest decreases in students’ interest and effort occur when they transition into secondary school, with students from low socioeconomic communities at greatest risk of disengagement. What can teachers do to engage their students during this key life transition? This project plans to identify teacher behaviours that motivate students in their first year at secondary school. Using an experimental design with a representative sample of 150 teachers and 1500 students in low socioeconomic areas across three states, the project plans to test whether an online professional learning program for teachers can improve student engagement and achievement. This cost-effective and scalable intervention is designed for widespread dissemination to Australian teachers.Read moreRead less
Building Citizenship Capacity in Young Adults With and Without Cerebral Palsy. This project will investigate practical aspects of citizenship participation within the context of a young adult population, as different from frequently reported theoretical views on citizenship. Specifically, the aim is to identify strategies necessary for building citizenship capacities for young adults with cerebral palsy (CP), as they are now living longer, but not eligible for care at the same level as during sc ....Building Citizenship Capacity in Young Adults With and Without Cerebral Palsy. This project will investigate practical aspects of citizenship participation within the context of a young adult population, as different from frequently reported theoretical views on citizenship. Specifically, the aim is to identify strategies necessary for building citizenship capacities for young adults with cerebral palsy (CP), as they are now living longer, but not eligible for care at the same level as during school years. Gaining capacities for success as a participating community member, young adults with CP need opportunities to manage not only physical and economic demands, but also develop knowledge and competencies necessary to engage in civic and social reciprocity within the community.Read moreRead less
Genetic rescue of Australian wildlife. Genetic rescue of Australian wildlife. This project aims to test genetic rescue as an efficient recovery technique for threatened plants and animals. Genetic rescue is under-utilised, even though it is overwhelmingly beneficial. This project will convert management actions on five Endangered/Critically Endangered species into rigorous experiments that measure the fitness benefits of genetic rescue, and demonstrate genome-wide consequences. Anticipated outco ....Genetic rescue of Australian wildlife. Genetic rescue of Australian wildlife. This project aims to test genetic rescue as an efficient recovery technique for threatened plants and animals. Genetic rescue is under-utilised, even though it is overwhelmingly beneficial. This project will convert management actions on five Endangered/Critically Endangered species into rigorous experiments that measure the fitness benefits of genetic rescue, and demonstrate genome-wide consequences. Anticipated outcomes include innovative genetic rescue protocols, a framework for genetic rescue, and leading-edge conservation training. Expected benefits are increased persistence of species that are otherwise unresponsive to management, and a new path to saving endangered species.Read moreRead less
The roles of scientific diagrams in contributing to science achievement and conceptual change. The project is designed to develop a body of research that facilitates excellence in teaching and in learning scientific diagrams in secondary school science. Benefits will include the dissemination of effective pedagogical strategies and improved science achievement measured by conceptual change from both cognitive and affective perspectives.
STEM education: Student attitudes, teacher relationships & emotional climate. This project aims to improve science, technology, engineering and mathematics (STEM) outcomes in schools, especially among females. This study will develop and validate a questionnaire to assess classroom emotional climate and investigate its mediating influence on teacher-student interactions and students’ effective outcomes. Focus groups will provide input into the interpretation and triangulation of questionnaire f ....STEM education: Student attitudes, teacher relationships & emotional climate. This project aims to improve science, technology, engineering and mathematics (STEM) outcomes in schools, especially among females. This study will develop and validate a questionnaire to assess classroom emotional climate and investigate its mediating influence on teacher-student interactions and students’ effective outcomes. Focus groups will provide input into the interpretation and triangulation of questionnaire findings and permit causal inferences. Expected outcomes include practical, research-based guidance to teachers for enhancing classroom emotional climate and motivating further study in STEM disciplines.Read moreRead less