Synthetic Molybdenum Enzymes. This project aims to produce synthetic molybdenum (Mo) enzymes, small molecules that share structural and functional attributes with the crucially important molybdopterin?Mo enzymes. These ubiquitous enzymes are essential for plant and animal health, natural cycles involving carbon, nitrogen and sulfur, and global climate control and atmospheric albedo (reflectance); consequently, they impact heavily on commerce, the environment and society. The study will provid ....Synthetic Molybdenum Enzymes. This project aims to produce synthetic molybdenum (Mo) enzymes, small molecules that share structural and functional attributes with the crucially important molybdopterin?Mo enzymes. These ubiquitous enzymes are essential for plant and animal health, natural cycles involving carbon, nitrogen and sulfur, and global climate control and atmospheric albedo (reflectance); consequently, they impact heavily on commerce, the environment and society. The study will provide urgently needed insights into the fundamental Mo?sulfur chemistry of the enzyme active sites and inform efforts to reduce the negative impacts of enzyme dysfunction and the design of new commercial catalysts.Read moreRead less
Bioinorganic Chemistry of Molybdenum. Enzymes containing the trace element molybdenum play crucial roles in plant, animal and human health, drug metabolism, environmental processes and climate. This international, multidisciplinary project will advance our understanding of the structure and function of these enzymes at the atomic level and inform strategies to reduce the impact of crop, livestock and human diseases and adverse environmental (e.g. algal blooms, leaching of toxic arsenic) and clim ....Bioinorganic Chemistry of Molybdenum. Enzymes containing the trace element molybdenum play crucial roles in plant, animal and human health, drug metabolism, environmental processes and climate. This international, multidisciplinary project will advance our understanding of the structure and function of these enzymes at the atomic level and inform strategies to reduce the impact of crop, livestock and human diseases and adverse environmental (e.g. algal blooms, leaching of toxic arsenic) and climatic events. Effective strategies would be of enormous social and economic benefit to Australia. The training of skilled scientists and access to major overseas facilities are additional benefits of the project.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668017
Funder
Australian Research Council
Funding Amount
$1,047,000.00
Summary
Membrane Protein Structure and Interaction Facility. While it is estimated that a third of the human genome encodes for membrane proteins, the structures of only relatively few membrane proteins are currently known. It will be some time before membrane protein structure determination becomes routine, yet over 50% of the drugs on the market today rely on the activity of membrane proteins for their efficacy. This application seeks to establish a Membrane Protein Structure and Interaction Facility ....Membrane Protein Structure and Interaction Facility. While it is estimated that a third of the human genome encodes for membrane proteins, the structures of only relatively few membrane proteins are currently known. It will be some time before membrane protein structure determination becomes routine, yet over 50% of the drugs on the market today rely on the activity of membrane proteins for their efficacy. This application seeks to establish a Membrane Protein Structure and Interaction Facility for the development and application of novel techniques and approaches to study the structure and interactions of membrane proteins. Research progress will be greatly enhanced by the establishment of this dedicated facility with cutting-edge technologies for the study of membrane proteins.Read moreRead less
Cross-linked Tyrosine Residues in Peptides and Proteins. Many peptides and proteins have recently been found to contain unusual structural modifications, commonly in the form of cross-linked tyrosine residues. The aims of this project are to design and synthesise examples of these cross-linked tyrosine structures, thereby enabling the preparation of models of the modified proteins. Outcomes of this research will include an increased understanding of the relationship between the three-dimensional ....Cross-linked Tyrosine Residues in Peptides and Proteins. Many peptides and proteins have recently been found to contain unusual structural modifications, commonly in the form of cross-linked tyrosine residues. The aims of this project are to design and synthesise examples of these cross-linked tyrosine structures, thereby enabling the preparation of models of the modified proteins. Outcomes of this research will include an increased understanding of the relationship between the three-dimensional structure and biological activity of peptides/proteins, the generation of lead compounds for new anti-bacterial and anti-fungal pharmaceuticals, and the preparation of biological 'markers' of the processes involved in neurodegenerative diseases and aging.Read moreRead less
Numerical Modelling and Experimental Studies to Design and Engineer Nanoparticulate Systems for Bioapplications. Project outcomes will enhance Australia's reputation for scientific innovation in the field of bio-nanotechnology. The project will expand the knowledge base in this area and increase Australia's international profile in research on nanomaterials for bio-related applications. The project partners UNSW and Australian company (Minomic), integrating their skills, expertise and facilities ....Numerical Modelling and Experimental Studies to Design and Engineer Nanoparticulate Systems for Bioapplications. Project outcomes will enhance Australia's reputation for scientific innovation in the field of bio-nanotechnology. The project will expand the knowledge base in this area and increase Australia's international profile in research on nanomaterials for bio-related applications. The project partners UNSW and Australian company (Minomic), integrating their skills, expertise and facilities to address current limitations in understanding the stability of magnetic nanoparticles in biological fluids. The Australian partners will play a leading role in commercializing new applications for functionalized magnetic nanoparticles. The project will provide an excellent multidisciplinary research environment and training for early career researchers.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989374
Funder
Australian Research Council
Funding Amount
$550,000.00
Summary
South Australian High-Resolution and Ion-Mobility Mass Spectrometry Facility. The analytical facility will enhance (i) fundamental research to understand the mechanisms of the reactions of charged species with neutral molecules, and (ii) the provision of structural information, including the precise atomic composition of any molecule, small or large. Research supported by this facility includes (a)nanotechnology, including supramolecular chemistry, (b) bioscience: cancer research, neurodegenera ....South Australian High-Resolution and Ion-Mobility Mass Spectrometry Facility. The analytical facility will enhance (i) fundamental research to understand the mechanisms of the reactions of charged species with neutral molecules, and (ii) the provision of structural information, including the precise atomic composition of any molecule, small or large. Research supported by this facility includes (a)nanotechnology, including supramolecular chemistry, (b) bioscience: cancer research, neurodegenerate diseases (e.g. Parkinson's disease) osteoarthritis, inflammation, cardiac diseases and synthetic approaches to anticancer and other drugs.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560862
Funder
Australian Research Council
Funding Amount
$546,700.00
Summary
South Australian Facility for Advanced Molecular Imaging. The aim of this project is to establish the South Australian Facility for Advanced Molecular Imaging. The Facility builds on existing expertise and cooperation between the collaborating institutions to expand our capability in advanced analytical confocal microscopy of a wide range of materials from living cells to artificial surfaces. New state-of-the-art microscopes will allow the direct quantitative analysis of molecular interactions w ....South Australian Facility for Advanced Molecular Imaging. The aim of this project is to establish the South Australian Facility for Advanced Molecular Imaging. The Facility builds on existing expertise and cooperation between the collaborating institutions to expand our capability in advanced analytical confocal microscopy of a wide range of materials from living cells to artificial surfaces. New state-of-the-art microscopes will allow the direct quantitative analysis of molecular interactions with high temporal and spatial resolutions. This will advance: understanding the regulation of cellular signalling, gene expression and growth in normal and pathological conditions; development of biosensor technology; and the application of new biomaterials in medicine and industry.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100010
Funder
Australian Research Council
Funding Amount
$720,000.00
Summary
A 5-D Correlative Imaging Platform: Combining the strengths of light and electron microscopy. This will be Australia's first dedicated five-dimensional multiphoton-microscopy platform, allowing observation of dynamic structures across different length and time scales under controlled temperatures, followed by high-resolution electron microscopy studies on the same samples. This platform will provide a unique characterisation tool to Australia's top-flight investigators, and so contribute to the ....A 5-D Correlative Imaging Platform: Combining the strengths of light and electron microscopy. This will be Australia's first dedicated five-dimensional multiphoton-microscopy platform, allowing observation of dynamic structures across different length and time scales under controlled temperatures, followed by high-resolution electron microscopy studies on the same samples. This platform will provide a unique characterisation tool to Australia's top-flight investigators, and so contribute to the nation's research priorities. It will enable: fundamental studies of cancer, neural diseases and immune disorders; the development of frontier technologies, such as smart nanomaterials, biosensors and targeted drug delivery; and applied research to help plants and soils adapt to climate variability, and to increase sustainable use of water.Read moreRead less