INTRINSIC PROPERTIES OF THE PORE FORMING DOMAIN OF THE RYANODINE RECEPTOR CALCIUM CHANNEL. The project is to understand how a calcium ion channel is able to regulate muscle performance. The ion channel, known as the ryanodine receptor, is essential for human and animal survival. The results of the project will be integral to understanding muscle performance in humans and will have long term implications for Australian sports physiology and sports science. The project will also be integral to ....INTRINSIC PROPERTIES OF THE PORE FORMING DOMAIN OF THE RYANODINE RECEPTOR CALCIUM CHANNEL. The project is to understand how a calcium ion channel is able to regulate muscle performance. The ion channel, known as the ryanodine receptor, is essential for human and animal survival. The results of the project will be integral to understanding muscle performance in humans and will have long term implications for Australian sports physiology and sports science. The project will also be integral to understanding muscle performance and development in animals and will have repercussions for the Australian livestock and racing industries. The results may lead to the development of new insecticides since insect mobility depends on ryanodine receptor activity. This will benefit to Australian agriculture.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989920
Funder
Australian Research Council
Funding Amount
$750,000.00
Summary
Microbial and Cellular Imaging and Analysis Facility. The Microbial and Cellular Imaging and Analysis Facility will rapidly establish itself as one of Australia's premier science facilities. It will provide the capacity to investigate the structure and molecular dynamics of viruses and microbial, human, animal and plant cells with unprecedented high resolution in both pure and applied research settings, guided by Australia's leading experts in many research strengths. This facility addresses a c ....Microbial and Cellular Imaging and Analysis Facility. The Microbial and Cellular Imaging and Analysis Facility will rapidly establish itself as one of Australia's premier science facilities. It will provide the capacity to investigate the structure and molecular dynamics of viruses and microbial, human, animal and plant cells with unprecedented high resolution in both pure and applied research settings, guided by Australia's leading experts in many research strengths. This facility addresses a current unmet need for scientists in this country and will provide cutting-edge technologies to Australian researchers so they can better detect, understand, and treat human, animal and plant diseases and the environmental impact of climate change.Read moreRead less
Special Research Initiatives - Grant ID: SR0354797
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
The Australian Tissue Engineering Network. Driven by four key nodes across the country, the Initiative aims to bring together geographically and financially separated groups into a critical mass of cell and tissue engineering research. This new and rapidly-growing field uses a bio-synthetic approach to replace, repair or regenerate damaged tissues and organs. The Initiative will build the framework which will enable the Network to: identify appropriate expertise, manage duplication, enhance co ....The Australian Tissue Engineering Network. Driven by four key nodes across the country, the Initiative aims to bring together geographically and financially separated groups into a critical mass of cell and tissue engineering research. This new and rapidly-growing field uses a bio-synthetic approach to replace, repair or regenerate damaged tissues and organs. The Initiative will build the framework which will enable the Network to: identify appropriate expertise, manage duplication, enhance communication, bring together innovative skill sets, create linkages, generate focussed research programs and foster novel commercial opportunities. Ultimately the Initiative and Network will deliver an improved quality of life, reduced healthcare costs, and increased productivity to Australia.Read moreRead less
Novel bioinformatics approaches for biological inference from comparative genomics data. Unlocking the potential of the human and other genome sequences depends almost entirely upon comparative genomics techniques. We will develop powerful bioinformatic models, implemented as high-performance computing solutions, for the examination of gene sequences. Improving these models, which represent the initial building block for all comparative genomics techniques, will be beneficial across genomics dep ....Novel bioinformatics approaches for biological inference from comparative genomics data. Unlocking the potential of the human and other genome sequences depends almost entirely upon comparative genomics techniques. We will develop powerful bioinformatic models, implemented as high-performance computing solutions, for the examination of gene sequences. Improving these models, which represent the initial building block for all comparative genomics techniques, will be beneficial across genomics dependent industries. A major outcome from this work will be an integrated software/hardware product optimised for statistical examination of very large-scale genomics data.Read moreRead less
The role of gamma glutamyl cyclotransferase in glutathione homeostasis. The aim of this study is to understand the structure and function of gamma-glutamyl cyclotransferase (GGCT) and its role in glutathione synthesis and turnover. Glutathione is essential for life and serves multiple biological functions protecting against oxidative stress, and aiding in the detoxification and excretion of foreign chemicals. This study will explore a new approach to changing intracellular glutathione concentra ....The role of gamma glutamyl cyclotransferase in glutathione homeostasis. The aim of this study is to understand the structure and function of gamma-glutamyl cyclotransferase (GGCT) and its role in glutathione synthesis and turnover. Glutathione is essential for life and serves multiple biological functions protecting against oxidative stress, and aiding in the detoxification and excretion of foreign chemicals. This study will explore a new approach to changing intracellular glutathione concentrations that has wide applications in the treatment of inherited enzyme deficiencies, cancer and the development of herbicide resistant crop plants. The study will also contribute to the training of scientists for the future development of the Australian biotechnology industryRead moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989541
Funder
Australian Research Council
Funding Amount
$1,000,000.00
Summary
High Field Solid State and Multinuclear NMR Spectrometer for Structure/Function Analysis of Materials. Projects requiring the proposed infrastructure are aligned with two of the National Research Priorities. The research will lead to the development of novel materials, polymers and drugs, in particular nanoporous molecular frameworks, as well as reactive catalysts. The understanding of protein structure, disease and metabolic pathways which will be established using the proposed equipment will c ....High Field Solid State and Multinuclear NMR Spectrometer for Structure/Function Analysis of Materials. Projects requiring the proposed infrastructure are aligned with two of the National Research Priorities. The research will lead to the development of novel materials, polymers and drugs, in particular nanoporous molecular frameworks, as well as reactive catalysts. The understanding of protein structure, disease and metabolic pathways which will be established using the proposed equipment will contribute to the priority area 'Promoting and Maintaining Good Health'. In addition, the new equipment will extend capabilities and postgraduate training in chemistry, nanotechnology, and biomedicine (the priority area of 'Frontier Technologies for Building and Transforming Australian Industries').Read moreRead less
Development of Control Methodologies for Drug Dosing in Biomedical Engineering. This research proposal is very relevant to the National Research Priorities in the areas of Frontier Technologies and Breakthrough science. At a broader level, we aim to assist in the development of a national competence in what has been an emerging and promising discipline. The research will develop fundamental and enabling laws and techniques for drug administration to regulate physiological variables such as blood ....Development of Control Methodologies for Drug Dosing in Biomedical Engineering. This research proposal is very relevant to the National Research Priorities in the areas of Frontier Technologies and Breakthrough science. At a broader level, we aim to assist in the development of a national competence in what has been an emerging and promising discipline. The research will develop fundamental and enabling laws and techniques for drug administration to regulate physiological variables such as blood pressure and degree of consciousness in critical care patients.Read moreRead less
Parasite virulence: the role of activation and suppression of P2X7 receptors. Toxoplasmosis and leishmaniasis pose a threat to the health and well-being of the Australian human and animal populations. Around 6-8 million Australians are infected with Toxoplasma, a parasite that can cause severe problems in immunosuppressed individuals and birth defects and miscarriage in pregnant women with a primary infection. Toxoplasmosis is also the main cause of abortion and stillbirth in Australian sheep. L ....Parasite virulence: the role of activation and suppression of P2X7 receptors. Toxoplasmosis and leishmaniasis pose a threat to the health and well-being of the Australian human and animal populations. Around 6-8 million Australians are infected with Toxoplasma, a parasite that can cause severe problems in immunosuppressed individuals and birth defects and miscarriage in pregnant women with a primary infection. Toxoplasmosis is also the main cause of abortion and stillbirth in Australian sheep. Leishmaniasis, recently found in Australia, is a risk for overseas travellers, livestock and wildlife. This research will provide an understanding of what makes these parasites successful, paving the way for development of novel drugs to combat these chronic diseases.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989726
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
Nanophotonic and Microfluidic Integration Facility: a Platform for Optofluidics. Emerging 'lab on a chip' technology promises to provide low-cost, mass produced platforms for monitoring and processing of environmental and biological samples (eg. water quality and early cancer detection). These essentially fluidic platforms will require integrated photonic components to provide the vast array of optical interrogation options that are used in all modern laboratories. The proposed facility will e ....Nanophotonic and Microfluidic Integration Facility: a Platform for Optofluidics. Emerging 'lab on a chip' technology promises to provide low-cost, mass produced platforms for monitoring and processing of environmental and biological samples (eg. water quality and early cancer detection). These essentially fluidic platforms will require integrated photonic components to provide the vast array of optical interrogation options that are used in all modern laboratories. The proposed facility will enable Australian researchers to effectively integrate nano-photonic structures with engineered micro-fluidics into a single optofluidic chip. This will bring researchers in photonics and microfluidics together and will provide platforms supporting support biomedical and environmental and even fundamental physics projects.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0454209
Funder
Australian Research Council
Funding Amount
$126,326.00
Summary
A Glycobiology Facility for Glycoconjugate Analysis and Oligosaccharide Sequencing. The carbohydrate moiety of glycoconjugates plays an important role in their function and metabolism. Advances in glycan analytical and oligosaccharide sequencing techniques offer tremendous potential for the application of glycobiology to biotechnology, cell biology and medicine. This application aims to establish a Glycobiology Facility dedicated to glycoconjugate analysis and oligosaccharide sequencing. Funds a ....A Glycobiology Facility for Glycoconjugate Analysis and Oligosaccharide Sequencing. The carbohydrate moiety of glycoconjugates plays an important role in their function and metabolism. Advances in glycan analytical and oligosaccharide sequencing techniques offer tremendous potential for the application of glycobiology to biotechnology, cell biology and medicine. This application aims to establish a Glycobiology Facility dedicated to glycoconjugate analysis and oligosaccharide sequencing. Funds are requested for state of the art HPLC equipment, associated equipment and reagents for glycan purification/labelling, and a staff member, that are all essential to establish this technology in Australia. The Facility will support $25 million of existing research; approximately half of which is derived from ARC.Read moreRead less