Novel bioinformatics approaches for biological inference from comparative genomics data. Unlocking the potential of the human and other genome sequences depends almost entirely upon comparative genomics techniques. We will develop powerful bioinformatic models, implemented as high-performance computing solutions, for the examination of gene sequences. Improving these models, which represent the initial building block for all comparative genomics techniques, will be beneficial across genomics dep ....Novel bioinformatics approaches for biological inference from comparative genomics data. Unlocking the potential of the human and other genome sequences depends almost entirely upon comparative genomics techniques. We will develop powerful bioinformatic models, implemented as high-performance computing solutions, for the examination of gene sequences. Improving these models, which represent the initial building block for all comparative genomics techniques, will be beneficial across genomics dependent industries. A major outcome from this work will be an integrated software/hardware product optimised for statistical examination of very large-scale genomics data.Read moreRead less
The role of the Ttyh1 protein in cell activation. We have cloned TTYH1, a human homologue of the Drosophila melanogaster tweety gene. The mouse gene has also been identified. The predicted structure of the protein is a membrane protein with 5 transmembrane domains. We have also expressed a GFP-tagged fusion protein in mouse fibroblasts. Confocal microscopy indicates that this protein is likely to be a novel adhesion molecule, with a cellular distribution characteristic of molecules such as integ ....The role of the Ttyh1 protein in cell activation. We have cloned TTYH1, a human homologue of the Drosophila melanogaster tweety gene. The mouse gene has also been identified. The predicted structure of the protein is a membrane protein with 5 transmembrane domains. We have also expressed a GFP-tagged fusion protein in mouse fibroblasts. Confocal microscopy indicates that this protein is likely to be a novel adhesion molecule, with a cellular distribution characteristic of molecules such as integrins. We aim to determine the function of Ttyh1, its interacting intra- and extra-cellular proteins and to assess its candidature as a molecule of importance in cell migration and adhesion.Read moreRead less
Obesity, Health, Social Disadvantage and Environment in Australia : Relationships and Policy Implications. The association between excess body fat and numerous health problems has been well documented. The significant increase in the proportion of Australians obese and overweight in the last 20 years has important implications for the well being of Australians and the costs of the health system. Developing effective policies to reverse this trend is dependant upon achieving better understandin ....Obesity, Health, Social Disadvantage and Environment in Australia : Relationships and Policy Implications. The association between excess body fat and numerous health problems has been well documented. The significant increase in the proportion of Australians obese and overweight in the last 20 years has important implications for the well being of Australians and the costs of the health system. Developing effective policies to reverse this trend is dependant upon achieving better understanding of the inter-related social, economic, environmental and medical causes of obesity and its effects. This study seeks to extend this understanding through innovative analysis of a unique survey of 4,000 adults in northwestern Adelaide and develop recommendations for effective policy intervention.Read moreRead less