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Research Topic : pediatric respiratory diseases
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  • Funded Activity

    Genetic And Environmental Factors And Early Lung Problems Can Be Related To Allergy And Poor Lung Development In Preschool Age Children

    Funder
    National Health and Medical Research Council
    Funding Amount
    $122,032.00
    Summary
    This important new collaboration between the Murdoch ChildrenÍs Research Institute and Barwon Health explores the impact of early lung development on longer term respiratory health. It utilises a newly validated, accurate and safe technique to measure lung function in young babies and children. Data on environmental factors and lung function will help us explore the risk factors for the development of allergy, asthma and lung infections in early life.
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    THE EFFECT OF LONG ACTING BRONCHODILATORS ON VENTILATION IN COPD

    Funder
    National Health and Medical Research Council
    Funding Amount
    $143,676.00
    Summary
    COPD is a common and important smoking-related lung disease. Well-established treatments with inhaled medications including long-acting bronchodilators have a proven clinical track record. However the physiological basis for their effects is still under investigation. This research examines some of the physiological changes in lung function and the response to long-acting bronchodilators in patients with COPD, and may help explain why some patients respond to therapy while others do not, leading .... COPD is a common and important smoking-related lung disease. Well-established treatments with inhaled medications including long-acting bronchodilators have a proven clinical track record. However the physiological basis for their effects is still under investigation. This research examines some of the physiological changes in lung function and the response to long-acting bronchodilators in patients with COPD, and may help explain why some patients respond to therapy while others do not, leading to more targeted therapeutics
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    Funded Activity

    Temporal Dynamics Of Mechanics In COPD

    Funder
    National Health and Medical Research Council
    Funding Amount
    $113,462.00
    Summary
    Chronic obstructive pulmonary disease (COPD) causes airway narrowing and lung destruction resulting in breathlessness and cough. Earlier detection of acute attacks of breathlessness may improve treatment, prevent progression and reduce risk of death. The forced oscillation technique can detect attacks earlier and is easy to perform. It will be used in this study for home monitoring with application of time series analyses to accurately detect change so that acute attacks can be treated earlier.
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    Funded Activity

    Protracted Bacterial Bronchitis(PBB) In Children - Natural History, Innate Immunity And Obstructive Sleep Disorders

    Funder
    National Health and Medical Research Council
    Funding Amount
    $97,438.00
    Summary
    Recurrent episodes of prolonged wet cough in children, termed Protracted Bacterial Bronchitis (PBB), may cause long term lung damage. I am a paediatric respiratory and sleep subspecialist in training. Through our research we will investigate for abnormalities in the immune system of children with recurring episodes of PBB and follow these children over a 2 year period to determine whether they go on to develop lung scarring. We will also be looking for a link between PBB and obstructive sleep pr .... Recurrent episodes of prolonged wet cough in children, termed Protracted Bacterial Bronchitis (PBB), may cause long term lung damage. I am a paediatric respiratory and sleep subspecialist in training. Through our research we will investigate for abnormalities in the immune system of children with recurring episodes of PBB and follow these children over a 2 year period to determine whether they go on to develop lung scarring. We will also be looking for a link between PBB and obstructive sleep problems in children.
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    Funded Activity

    ED Cough Study

    Funder
    National Health and Medical Research Council
    Funding Amount
    $48,335.00
    Summary
    Acute respiratory illness and cough in children accounts for a substantial proportion of childhood morbidity and associated costs. This project aims to identify how many children develop a chronic cough after acute respiratory infection, what the risk factors are, how it affects everyday life and how much it costs families and society. This information will help inform health policy and guidelines to facilitate early detection of chronic lung disease and reduce the burden of coughing illness in .... Acute respiratory illness and cough in children accounts for a substantial proportion of childhood morbidity and associated costs. This project aims to identify how many children develop a chronic cough after acute respiratory infection, what the risk factors are, how it affects everyday life and how much it costs families and society. This information will help inform health policy and guidelines to facilitate early detection of chronic lung disease and reduce the burden of coughing illness in children.
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    Funded Activity

    Lung Volume Recruitment In Neuromuscular Disease: Can Breath-stacking Improve Lung Function, Respiratory Symptoms And Quality Of Life In People With Neuromuscular Disorders?

    Funder
    National Health and Medical Research Council
    Funding Amount
    $108,845.00
    Summary
    Difficulty taking deep breaths or coughing are two of the breathing complications people with a neuromuscular disease can face. Lung volume recruitment, also known as breath-stacking, is a simple and inexpensive therapy that may help. This research will look at the short and medium-term effects of breath-stacking exercises on the breathing system. If lung volume, chest stiffness and cough effectiveness improve then symptoms, quality of life and potentially survival are likely to be better.
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    Funded Activity

    Knowledge, Attitude And Practice Of Parents And Primary Care Providers In The Prevention And Management Of Respiratory Tract Infections In Young Children

    Funder
    National Health and Medical Research Council
    Funding Amount
    $84,782.00
    Summary
    Respiratory tract infections (RTIs) account for over 6 million GP visits each year in Australia and children <5 years of age are especially vulnerable. Although preventive and management activities, such as flu vaccinations and hand-washing, have been shown to be efficacious, programs which target RTIs in young children are limited. This proposal aims to understand the current knowledge, attitudes and practice of parents and providers in the prevention and management of RTIs in young children .... Respiratory tract infections (RTIs) account for over 6 million GP visits each year in Australia and children <5 years of age are especially vulnerable. Although preventive and management activities, such as flu vaccinations and hand-washing, have been shown to be efficacious, programs which target RTIs in young children are limited. This proposal aims to understand the current knowledge, attitudes and practice of parents and providers in the prevention and management of RTIs in young children.
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    Funded Activity

    Non-invasive Methods Of Measuring Work Of Breathing In Children

    Funder
    National Health and Medical Research Council
    Funding Amount
    $41,267.00
    Summary
    Sleep-disordered breathing such as obstructive sleep apnoea, is currently diagnosed if a child stops breathing more than once per hour. For children with asthma or cystic fibrosis, who may not stop breathing during the night, how hard their breathing muscles work can have a significant impact on their health. A non-invasive method of measuring respiratory effort, and incorporating this measurement into how sleep-disordered breathing is diagnosed, can revolutionize how sleep-disordered breathing .... Sleep-disordered breathing such as obstructive sleep apnoea, is currently diagnosed if a child stops breathing more than once per hour. For children with asthma or cystic fibrosis, who may not stop breathing during the night, how hard their breathing muscles work can have a significant impact on their health. A non-invasive method of measuring respiratory effort, and incorporating this measurement into how sleep-disordered breathing is diagnosed, can revolutionize how sleep-disordered breathing in children are managed world-wide.
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    Funded Activity

    Improving Health-related Quality Of Life In Patients Receiving Home Mechanical Ventilation

    Funder
    National Health and Medical Research Council
    Funding Amount
    $121,793.00
    Summary
    Home mechanical ventilation (HMV) is a treatment that assists someone to breathe using a machine. People may need HMV when their breathing has failed due to conditions such as chronic obstructive pulmonary disease (COPD), neuromuscular disease (NMD) or severe obesity. This project will examine the quality of life of patients receiving HMV in Australia and Canada. It will also determine if we can improve the treatment by using a sleep study to monitor breathing when patients first start HMV.
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    Funded Activity

    Reference Values For Spirometry, Lung Volumes, Diffusing Capacity, And Fractional Exhaled Nitric Oxide In First Nations Australians

    Funder
    National Health and Medical Research Council
    Funding Amount
    $83,832.00
    Summary
    Reference values in lung function tests allow respiratory doctors to accurately interpret results in order to effectively diagnose, treat and manage respiratory disease. Currently, reference values do not exist for First Nations adults. I will recruit 600 healthy First Nations adults from communities in Queensland and the Northern Territory for several lung function tests. Data collected will be submitted to the Global Lung Function Initiative to be incorporated into future guidelines.
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    Showing 1-10 of 71 Funded Activites

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