High-resolution multiscale modelling of pandemics: COVID-19 and beyond. The project aims to develop high-resolution computational models for pandemic mitigation and control, focussing on the novel coronavirus and its emerging variants, and leveraging demographic, genomic and epidemiological data. It expects to rigorously compare multi-scale effects of complex vaccination and social distancing strategies and quantify optimal responses under the COVID-19 induced uncertainty. The intended outcomes ....High-resolution multiscale modelling of pandemics: COVID-19 and beyond. The project aims to develop high-resolution computational models for pandemic mitigation and control, focussing on the novel coronavirus and its emerging variants, and leveraging demographic, genomic and epidemiological data. It expects to rigorously compare multi-scale effects of complex vaccination and social distancing strategies and quantify optimal responses under the COVID-19 induced uncertainty. The intended outcomes include computational models of how the most infectious viral variants emerge and spread in presence of interventions, how to predict the outbreaks, and which are the most vulnerable communities. This should make a significant economic and social impact, improving population health while maintaining a resilient economy.Read moreRead less
Quantifying emergence and dynamics of foodborne epidemics in Australia. The project aims to greatly improve the accuracy and scope of computational epidemiological models predicting emergence and evolution of foodborne diseases in Australia. It expects to reveal key pathways for both biological evolution of microorganisms, and their spread though food supply chains and human interactions. The intended outcomes include discovering how the most dominant strains of foodborne infection emerge and se ....Quantifying emergence and dynamics of foodborne epidemics in Australia. The project aims to greatly improve the accuracy and scope of computational epidemiological models predicting emergence and evolution of foodborne diseases in Australia. It expects to reveal key pathways for both biological evolution of microorganisms, and their spread though food supply chains and human interactions. The intended outcomes include discovering how the most dominant strains of foodborne infection emerge and self-organise in complex networks, how to predict and contain the epidemics closer to their source, and which are the most vulnerable groups and communities. This should make a significant economic and social impact, improving health of the population, while also safeguarding national and international supply chains.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL140100025
Funder
Australian Research Council
Funding Amount
$2,617,462.00
Summary
The physical brain: emergent, multiscale, nonlinear, and critical dynamics. The physical brain: emergent, multiscale, nonlinear, and critical dynamics. This project aims to transform the understanding of the structure and function of the brain as a complex physical system. It aims to reveal and unify new aspects of information processing, transitions in conscious state, and nonlinear brain interactions by translating and applying concepts and methods from physics and mathematics. It will treat b ....The physical brain: emergent, multiscale, nonlinear, and critical dynamics. The physical brain: emergent, multiscale, nonlinear, and critical dynamics. This project aims to transform the understanding of the structure and function of the brain as a complex physical system. It aims to reveal and unify new aspects of information processing, transitions in conscious state, and nonlinear brain interactions by translating and applying concepts and methods from physics and mathematics. It will treat brain structure and dynamics together to address emergent phenomena like waves and patterns on multiple scales, treating waves as equal participants alongside neurons. Innovative predictions of brain phenomena will aim to be verified against data and used to understand brain networks, dynamics, and the physical phenomena underlying information processing and consciousness.Read moreRead less
Functional magnetic resonance imaging: Decoding the palimpsest. This project aims to model the dynamics of functional magnetic resonance imaging (fMRI) to image new physiology and attain higher resolution. This will enable new aspects of brain dynamics to be imaged, achieving higher resolution and improving interpretation. This project is expected to improve the use and power of fMRI, unlock new avenues for probing brain function and save experimental costs. This will have many uses in neuroscie ....Functional magnetic resonance imaging: Decoding the palimpsest. This project aims to model the dynamics of functional magnetic resonance imaging (fMRI) to image new physiology and attain higher resolution. This will enable new aspects of brain dynamics to be imaged, achieving higher resolution and improving interpretation. This project is expected to improve the use and power of fMRI, unlock new avenues for probing brain function and save experimental costs. This will have many uses in neuroscience, brain imaging technology and fMRI analysis software.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101375
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
The forest and the trees: How global brain rhythms facilitate local information processing. One of the greatest challenges in understanding the brain is the enormous range of scales it operates on, from single neurons a few microns across to entire hemispheres on the scale of tens of centimetres. This project will investigate how large-scale brain rhythms influence and facilitate information processing, particularly motor control, among small networks of individual neurons. The research question ....The forest and the trees: How global brain rhythms facilitate local information processing. One of the greatest challenges in understanding the brain is the enormous range of scales it operates on, from single neurons a few microns across to entire hemispheres on the scale of tens of centimetres. This project will investigate how large-scale brain rhythms influence and facilitate information processing, particularly motor control, among small networks of individual neurons. The research questions will be addressed by combining detailed computer simulations with data-driven analyses of empirical human and monkey brain dynamics. The outcomes of this project will provide a richer understanding of how our brains encode and process information, leading to practical benefits such as improved control of artificial limbs.Read moreRead less
Spatiotemporal dynamics and analysis of functional magnetic resonance imaging. Functional magnetic resonance imaging (fMRI) produces signals generated by brain activity in fine detail, but links between activity and images are poorly understood, posing a barrier to full use of the technology. Predictions from our new theory of such links will be made, tested experimentally and used to improve fMRI and discover new phenomena.
Light on a nanoscale: channelling energy through space and time to control neuronal activity. Quantum-mechanical effects of energy transfer and resonance will be harnessed to yield ultrabright nanoscale light sources. Research will unveil the intricate interplay between energy harvesting, transferring and emitting centres designed so that the flow of energy exhibits a directed character. This focussed intense energy will produce abundant visible photons from infrared light. Genetically engineere ....Light on a nanoscale: channelling energy through space and time to control neuronal activity. Quantum-mechanical effects of energy transfer and resonance will be harnessed to yield ultrabright nanoscale light sources. Research will unveil the intricate interplay between energy harvesting, transferring and emitting centres designed so that the flow of energy exhibits a directed character. This focussed intense energy will produce abundant visible photons from infrared light. Genetically engineered cells able to be stimulated optically by using an optogenetics method will be illuminated by our nanoscale light causing modulation of cell activity. This new capability will enable remote control of neuronal activity in specific circuits within the nervous system without the limitation of surgically inserted optical fibres.Read moreRead less