Implications Of Bacterial Load For Vaccine Efficacy And Antibiotic Treatment Outcomes In High-risk Populations
Funder
National Health and Medical Research Council
Funding Amount
$345,000.00
Summary
Otitis media (middle ear disease) is a common childhood infection, and a major concern in remote Aboriginal communities of the Northern Territory. For these children, otitis media commences within the first few weeks of life and progresses to perforation of the ear drum in 60% of children by 12 months of age. Few children in remote Aboriginal communities have normal ear status or normal hearing and many have conductive hearing loss, affecting language development and education. Otitis media in t ....Otitis media (middle ear disease) is a common childhood infection, and a major concern in remote Aboriginal communities of the Northern Territory. For these children, otitis media commences within the first few weeks of life and progresses to perforation of the ear drum in 60% of children by 12 months of age. Few children in remote Aboriginal communities have normal ear status or normal hearing and many have conductive hearing loss, affecting language development and education. Otitis media in these children results from infection with the bacteria Streptococcus pneumoniae, Haemophilus influenzae and-or Moraxella catarrhalis. Therefore the types of interventions we are using to combat the high prevalence of ear disease are antibiotic therapy, Streptococcus pneumoniae vaccination, and hygiene interventions. However we fear that the high load of bacteria carried by these children compromises the treatment and prevention strategies. The current proposal will test this hypothesis, and if found to be true, there will be implications for the management of otitis media. For example, dose, frequency and choice of antibiotic treatment, and vaccine schedule changes including an early dose or a booster dose.Read moreRead less
Multicentre Evaluation Of A Clinical Pathway For Chronic Cough In Children- Can Its Use Improve Clinical Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$971,362.00
Summary
Chronic cough is a common presenting symptom to doctors. It is associated with significant morbidity and may be a symptom of a serious underlying problem. This is especially pertinent to Aboriginal children. In this study we will examine the utility and efficacy of an evidence based clinical pathway for the management of chronic cough in Aboriginal and non-Aboriginal children. This study will contribute to clinical policy and improve clinical outcomes and early diagnosis of respiratory illnesses
Centre Of Clinical Research Excellence In Aboriginal Health
Funder
National Health and Medical Research Council
Funding Amount
$1,899,510.00
Summary
The Centre's mission is to improve Aboriginal health. It will conduct Aboriginal community-controlled population health and outcome-oriented research on strategies and systems that support individuals and communities to prevent and manage chronic diseases. The Centre will provide a range of research and other training opportunities for Aboriginal people, building the capacity of Aboriginal communities to direct and conduct their own health research independently. The Centre will be led by the Ab ....The Centre's mission is to improve Aboriginal health. It will conduct Aboriginal community-controlled population health and outcome-oriented research on strategies and systems that support individuals and communities to prevent and manage chronic diseases. The Centre will provide a range of research and other training opportunities for Aboriginal people, building the capacity of Aboriginal communities to direct and conduct their own health research independently. The Centre will be led by the Aboriginal Health Council of South Australia in partnership with Flinders University.Read moreRead less
I am a paediatrician and respiratory physician with a passion in Aboriginal and Torres Strait Islander health and evidence-based clinical practice. My research is built upon a philosophy that encompasses linkages between research, quality clinical work an
Judicious Use Of Antibiotics For Acute Otitis Media In Aboriginal Children: A Multi-centre Clinical Trial
Funder
National Health and Medical Research Council
Funding Amount
$614,840.00
Summary
Aboriginal children living in remote communities have the highest rates of severe ear infections and associated hearing loss currently reported in the medical literature. In some rural and remote Aboriginal communities, all infants have their first infection by 3 months of age and up to 60% develop chronic suppurative otitis media (pus draining from the ears) in the first year of life. By the time they reach school-age more than 50% of children have a significant hearing loss. This has important ....Aboriginal children living in remote communities have the highest rates of severe ear infections and associated hearing loss currently reported in the medical literature. In some rural and remote Aboriginal communities, all infants have their first infection by 3 months of age and up to 60% develop chronic suppurative otitis media (pus draining from the ears) in the first year of life. By the time they reach school-age more than 50% of children have a significant hearing loss. This has important implications for their education. The aim of this study is to determine whether a new longer-acting antibiotic will be more effective in treating young Aboriginal children with new ear infections and therefore prevent the progression to chronic suppurative otitis media. The involvement of up to 20 Aboriginal communities in this well-designed clinical trial represents a major advance in the methods used to evaluate interventions in Aboriginal health. The project will also provide training in ear examination and appropriate medical management. Swabs from the nose will be taken to monitor the effect of antibiotics on the rates of antibiotic resistance. The results from this study will be directly relevant to evidence-based guidelines on the management of otitis media in Aboriginal and Torres Strait Islander populations.Read moreRead less
Evaluation Of The Effectiveness Of Mobile Preschool For Child Health And Development In Remote Aboriginal Communities
Funder
National Health and Medical Research Council
Funding Amount
$456,369.00
Summary
This project is a retrospective study of the effectiveness of the NT Mobile Preschool Program using assessment data for children's emergent literacy, social and emotional competencies and health status. Effectiveness will be established by comparison with achievement and health status data for children not attending preschool and those in communities with no preschool service. The study will identify and describe the key factors influencing the health and learning outcomes of the three groups.
Antecedents Of Renal Disease In Aboriginal Children And Young Adults - 12 Year Follow-up
Funder
National Health and Medical Research Council
Funding Amount
$1,845,061.00
Summary
Aboriginal Australians have 2 to 10 times the rate of chronic kidney disease and premature death from cardiovascular disease compared with non-Aboriginal Australians. Our 6 year follow-up of Aboriginal children from diverse NSW areas has shown no increase in risk for these diseases when compared with non-Aboriginal children. The ARDAC Second Phase Study will follow the participants for another 6 years to determine whether these health disparities start to manifest in young Aboriginal adults.