Development Of Site-specific Predictive Assay For Periodontal Disease Progression Using Mass Spectrometric &RT- PCR Anal
Funder
National Health and Medical Research Council
Funding Amount
$150,000.00
Summary
In this project new DNA-based technology will be developed to determine the numbers of specific bacteria in the dental plaque of patients. The project will also use new mass spectrometric analysis techniques for the determination of compounds in gingival crevicular fluid, an exudate from the gums. These two techniques will be used in a clinical trial to determine if periodontal (gum) disease progression can be predicted by changes in the numbers of bacteria or in the composition of gingival crev ....In this project new DNA-based technology will be developed to determine the numbers of specific bacteria in the dental plaque of patients. The project will also use new mass spectrometric analysis techniques for the determination of compounds in gingival crevicular fluid, an exudate from the gums. These two techniques will be used in a clinical trial to determine if periodontal (gum) disease progression can be predicted by changes in the numbers of bacteria or in the composition of gingival crevicular fluid. This could provide insight into the development of periodontal disease and lead to new preventive and treatment regimes.Read moreRead less
Australia & New Zealand Musculoskeletal (ANZMUSC) Clinical Trials Network
Funder
National Health and Medical Research Council
Funding Amount
$2,497,654.00
Summary
Arthritis and musculoskeletal conditions place an immense and growing burden on the world’s population. They affect 28% of Australians (>6.1 million people). With the support of CRE funding, the Australia and New Zealand Musculoskeletal (ANZMUSC) Clinical Trials Network will optimise musculoskeletal health through high quality, collaborative clinical research, building research capacity and effective transfer of research outcomes into clinical practice and health policy.
Broadening Choice and Increasing Diversity in Public Schools. Currently, most families are limited to the public school in their catchment area, meaning the area in which they can afford to live. This leads to socio-economically and ethnically homogenous schools and entrenches disadvantage, as well as denying students the crucial life lessons that flow from being part of a diverse student body. This project aims to investigate a model for allocating public school places that integrates catchment ....Broadening Choice and Increasing Diversity in Public Schools. Currently, most families are limited to the public school in their catchment area, meaning the area in which they can afford to live. This leads to socio-economically and ethnically homogenous schools and entrenches disadvantage, as well as denying students the crucial life lessons that flow from being part of a diverse student body. This project aims to investigate a model for allocating public school places that integrates catchment areas. The expected outcome would be a system that gives families a wider choice, enabling them to enrol in out-of-area schools, while ensuring that allocations remain fair, equitable and balanced, and also delivering benefits such as achieving a desired level of diversity in student populations within schoolsRead moreRead less
Reducing Peer Victimisation In Australian Schools Through Targeted And Universal Approaches
Funder
National Health and Medical Research Council
Funding Amount
$1,063,531.00
Summary
Peer victimisation is a significant problem for young people in Australia and can lead to devastating long-term consequences including poor self esteem, depression and suicide. The current project aims to identify the most cost effective methods to reduce peer victimisation in schools. This will combine programs applied across the whole school with a more targeted program building resilience in vulnerable children. The results will have important implications for anti-bullying policies in school ....Peer victimisation is a significant problem for young people in Australia and can lead to devastating long-term consequences including poor self esteem, depression and suicide. The current project aims to identify the most cost effective methods to reduce peer victimisation in schools. This will combine programs applied across the whole school with a more targeted program building resilience in vulnerable children. The results will have important implications for anti-bullying policies in schools.Read moreRead less
Pathways To Prevention: The Effectiveness Of Universal And Selective Prevention In Altering Developmental Pathways To Alcohol And Cannabis Related Harms In Young Adults
Funder
National Health and Medical Research Council
Funding Amount
$465,967.00
Summary
This project will assess the potential long-term benefits for young Australians of two school-based drug prevention programs (Climate Schools and Preventure) compared to drug education as usual. This world-first study will inform national and international policy by evaluating whether prevention programs delivered in Year 8 are effective in reducing alcohol and cannabis related harms, including risk of aggression and violence, over the high risk period during young adulthood (ages 18-20).
A Randomised Controlled Trial Of Caseload Midwifery Care
Funder
National Health and Medical Research Council
Funding Amount
$761,311.00
Summary
There is concern about the rising levels of caesarean section in Australia and some evidence that women may benefit from caseload midwifery care. This randomised control trial will determine whether caseload midwifery care can reduce interventions and is as safe as usual hospital maternity care. A Cochrane systematic review of midwifery led care versus routine care was designed to answer these questions.This will be the first randomised controlled trial to contribute to this review
Mechanisms Underlying APOBEC3G Restriction Of HIV-1
Funder
National Health and Medical Research Council
Funding Amount
$540,075.00
Summary
In the fight against worldwide HIV-AIDS, understanding natural cell defenses to the HIV virus may identify new virus targets and strategies to block HIV in humans. Here, we will use state-of-the-art, high resolution, fluorescent microscopy to understand how the recently identified cell protein, APOBEC3G, blocks the HIV life cycle in human cells. We anticipate that APOBEC3G will stop HIV from invading the nucleus of human cells to defend against HIV, a strategy we can apply to new therapies.
Testing strategy-proofness in matching markets: an experimental study. This project seeks to test and improve matching algorithms by investigating the effect of advice on strategy-proofness. Matching algorithms are used to solve allocation problems in designed markets (eg school or house allocation problems). Many of the algorithms employed are strategy-proof: participants never gain from strategising, that is, from lying about their preferences. Strategy-proofness had been seemingly validated b ....Testing strategy-proofness in matching markets: an experimental study. This project seeks to test and improve matching algorithms by investigating the effect of advice on strategy-proofness. Matching algorithms are used to solve allocation problems in designed markets (eg school or house allocation problems). Many of the algorithms employed are strategy-proof: participants never gain from strategising, that is, from lying about their preferences. Strategy-proofness had been seemingly validated by experimental research, but new evidence suggests that participants could be prone to follow wrong advice and therefore lie. In order to improve the performance of designed markets, the project proposes to further test strategy-proofness by investigating how advice can affect truth-telling in strategy-proof algorithms and whether learning can counteract or complement the effect of advice.Read moreRead less
Antibiotic resistance is a looming public health crisis. New antibiotics with new mechanisms of action are desperately needed. The long-term goal of this research is to develop new drugs that disarm bacteria to overcome the problem of antibiotic resistance.