A New Virus Causing Acute Gastroenteritis In Humans
Funder
National Health and Medical Research Council
Funding Amount
$575,374.00
Summary
Diarrhoea is very common, especially in children but a cause is often not found. Believing there must be undiscovered viruses responsible, we developed a new method to look for them, and discovered one, which we have named adelavirus, in 17% of children with diarrhoea presenting to the WCH, Adelaide, over a 3 month period. 55% were hospitalised. This project proposes to investigate how widespread adelavirus infection is in the community and investigate how a vaccine might be developed.
Molecular Evolution And Rapid Typing Of Enteroviruses By Molecular Methods
Funder
National Health and Medical Research Council
Funding Amount
$44,934.00
Summary
Human enteroviruses (HEVs) are common human pathogens associated with a wide spectrum of symptoms ranging from asymptomatic infection to serious illness, especially in infants and the immunocompromised. They are responsible for large outbreaks of diseases. We will develop rapid molecular typing methods for enteroviruses, including reverse line blot hybridization and rolling circle amplification. Meanwhile, we will analyze molecular evolution of important enteroviruses over time.