The Landscape Of Cancer Genes And Associations With Prognosis In Breast Cancer Diagnosed In Premenopausal Women
Funder
National Health and Medical Research Council
Funding Amount
$700,512.00
Summary
Using state of the art technology, the purpose of this project is understand the implications of known cancer mutations in breast cancer diagnosed in premenopausal ER-positive breast cancer. Mutations are abnormalities in the DNA of genes that can provide a signal for uncontrolled growth, a hallmark of cancer. The unique aspect of this project is use of tissue samples from patients who were diagnosed with breast cancer at a young age. This information will help us develop new treatments.
Identification Of The Molecular Hallmarks Of Naevi Progressing To Melanoma
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Melanomas are amongst the most commonly occurring cancers in Australia with >136,000 people living with a previous melanoma diagnosis. One of the highest risk factors for developing melanoma is having a high number of moles (or naevi). It is therefore important to fully understand how and why naevi develop into melanoma. It is hoped that early detection markers will be identified which will help identify early melanomas and as such improve patient outcome.
Discovery, Preclinical And Translational Research In Endometrial Cancer
Funder
National Health and Medical Research Council
Funding Amount
$451,716.00
Summary
My research program is focused on “bench to bedside” translational research in uterine cancer. Specifically, identifying the genetic aberrations underlying the development of uterine cancer, understanding the function of these genes in normal and cancer cells, providing proof of principle data that drugs targeting these defective proteins induce cancer cell death in vitro and in vivo and identifying factors associated with whether a patient will respond to one particular treatment over another.