Complete Genomics For Mechanistic Insight And Precision Treatments Of Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$1,149,207.00
Summary
This research project will utilise recent developments in genomic technology to make detailed high-resolution genetic maps of individuals with psychotic illness. Where conventional gene discovery approaches focus on differences at the population level, this project will integrate the variation within individuals to determine the network architecture. This will be used to generate genetic profiles for personalised medicine and provide the basis for treatments that are tailored to individuals.
Defining The Genomic Basis Of Mitochondrial Complex I Deficiency
Funder
National Health and Medical Research Council
Funding Amount
$639,682.00
Summary
The human genome project led to new technologies that will revolutionise genetic testing. Previously, we could only sequence genes one at a time. Next Generation sequencing allows analysis of hundreds or thousands of genes simultaneously. We will analyse 90 genes in 100 children with severe disorders of mitochondrial energy generation. This will provide proof of principle for the introduction of this technology into routine medical testing and identify new genes causing these diseases.