Barrett's oesophagus (BO) is a condition that arises in some patients with chronic reflux (heartburn) and increases the risk of developing cancer of the oesophagus. However, the exact mechanisms involved in its development are unknown. This project aims to investigate how a protein called sonic hedgehog might be involved using novel cell culturing techniques that allow us to model the growth of oesophageal tissue in the laboratory. This could lead to development of new therapies for treating BO.
The Role Of The Mammalian Grainyhead-like Gene Family In Neural Tube Closure
Funder
National Health and Medical Research Council
Funding Amount
$569,541.00
Summary
Failure of the skin to close over the brain and spinal cord during human development results in the devastating congenital birth defects anencephaly and spina bifida, known collectively as the neural tube defects. These are the second most common congenital birth defects affecting 1:1000 pregnancies. Anencephaly is not compatible with life and affected babies die at birth. In contrast children with spina bifida survive, but suffer from limb paralysis, bowel and bladder dysfunction, learning diff ....Failure of the skin to close over the brain and spinal cord during human development results in the devastating congenital birth defects anencephaly and spina bifida, known collectively as the neural tube defects. These are the second most common congenital birth defects affecting 1:1000 pregnancies. Anencephaly is not compatible with life and affected babies die at birth. In contrast children with spina bifida survive, but suffer from limb paralysis, bowel and bladder dysfunction, learning difficulties and psycho-social disturbances. Our laboratories have identified a family of genes essential for the colsure of the neural tube in mammals. The aim of this proposal is to understand the mechanisms of action with a view to developing new therapeutics that mey be used preventatively in these conditions. We also hope that these studies may facilitate the development of a genetic test to screen couples at risk.Read moreRead less
Peopling educational policy: realising the new Australian English and mathematics curricula. Implementation of Australian curricula in English and mathematics provides an opportunity for school systems to re-examine practice. This project will identify resources and teacher learning opportunities needed to facilitate implementation of these curricula and use findings to develop interventions identified as likely to optimise implementation.
The Lexicon Project: Analysing pedagogical naming systems from different cultures to reconceptualise classroom practice and advance educational theory. Classrooms remain the principal site of institutionalised learning. Their cultural specificity poses challenges for international comparative research. New approaches are needed. Internationally, our educational theories, research and descriptions of practice are framed in English, which names some aspects of the classroom, but ignores key aspect ....The Lexicon Project: Analysing pedagogical naming systems from different cultures to reconceptualise classroom practice and advance educational theory. Classrooms remain the principal site of institutionalised learning. Their cultural specificity poses challenges for international comparative research. New approaches are needed. Internationally, our educational theories, research and descriptions of practice are framed in English, which names some aspects of the classroom, but ignores key aspects named in other languages. This limits our capacity to access, connect and adapt the wisdom of other cultures. The Lexicon Project will initiate cross-cultural dialogue to identify pedagogical terms from selected Asian and European educational communities and use these as analytical tools to categorise, interrogate and enrich our classroom practice, classroom research, and educational theorising.Read moreRead less
Using mathematics to solve real world problems. This project aims to identify, apply and refine teaching approaches that help secondary students learn mathematical modelling, using mathematics to solve real world problems. The study will investigate the mathematical, cognitive, social and environmental factors that "enable" Year 10/11 students to develop mathematical representations of a real world problem. This project expects to generate theoretical and practical insights into how these enable ....Using mathematics to solve real world problems. This project aims to identify, apply and refine teaching approaches that help secondary students learn mathematical modelling, using mathematics to solve real world problems. The study will investigate the mathematical, cognitive, social and environmental factors that "enable" Year 10/11 students to develop mathematical representations of a real world problem. This project expects to generate theoretical and practical insights into how these enablers promote successful modelling, tasks that support students' development as modellers, and effective teaching approaches that promote student capability and interest in mathematics.Read moreRead less
Investigating the relationship between teacher expectations, student persistence and the learning of mathematics. There is a culture in many classrooms in which teachers are encouraged by students to pose easy tasks. The project will explore what is needed to encourage students to embrace challenges and to persist even when tasks are difficult. The outcome will be enhanced mathematics learning and improved student confidence.
Improving student outcomes: coaching teachers in the power of feedback. This project aims to investigate how student outcomes can be augmented through coaching teachers in effective feedback practice. The project addresses a critical problem of stagnating levels of student achievement in Australian schools with the innovative research design combining evidence-based, pedagogies of feedback, formative assessment and instructional coaching to improve teacher practice and ultimately raise student a ....Improving student outcomes: coaching teachers in the power of feedback. This project aims to investigate how student outcomes can be augmented through coaching teachers in effective feedback practice. The project addresses a critical problem of stagnating levels of student achievement in Australian schools with the innovative research design combining evidence-based, pedagogies of feedback, formative assessment and instructional coaching to improve teacher practice and ultimately raise student achievement levels. The project aims to guide policy implementation in pedagogy to raise the quality of teaching standards and to improve learning outcomes for Australian students. Ultimately, outcomes from the research will help close the gap for low achieving students, and challenge and extend those who may already be meeting required benchmarks. Read moreRead less
Multiliteracies for addressing disadvantage in senior school science. Multiliteracies for addressing disadvantage in senior school science. This project aims to develop discipline-specific pedagogies in senior physics, chemistry and biology to improve disadvantaged students’ engagement and achievement. Many students from disadvantaged backgrounds fail to develop the linguistic precision and symbolic representational dexterity needed to comprehend and communicate senior school science concepts. T ....Multiliteracies for addressing disadvantage in senior school science. Multiliteracies for addressing disadvantage in senior school science. This project aims to develop discipline-specific pedagogies in senior physics, chemistry and biology to improve disadvantaged students’ engagement and achievement. Many students from disadvantaged backgrounds fail to develop the linguistic precision and symbolic representational dexterity needed to comprehend and communicate senior school science concepts. These pedagogies will ‘infuse’ multiliteracies in senior school science to improve access to science-based pathways for these students, and enable them to understand progressively more complex scientific concepts and demonstrate this in examinations. This project is expected to improve student retention, arrest declining enrolments in senior school science, and increase young people working in science.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100515
Funder
Australian Research Council
Funding Amount
$423,652.00
Summary
Teaching digital writing in secondary English. In a digital world the nature of writing is changing. This project investigates how secondary English teachers are conceptualising and teaching digital writing, and how they perceive this work can be enhanced to create more engaged and empowered students, workers and citizens. The study contextualises contemporary digital writing pedagogy in the history of English teaching and provides insights into how teachers respond to demands for 21st century l ....Teaching digital writing in secondary English. In a digital world the nature of writing is changing. This project investigates how secondary English teachers are conceptualising and teaching digital writing, and how they perceive this work can be enhanced to create more engaged and empowered students, workers and citizens. The study contextualises contemporary digital writing pedagogy in the history of English teaching and provides insights into how teachers respond to demands for 21st century literacies. The project, of both national and international significance, will contribute to policy, professional learning and teacher education, and shape capacity for the education of adept writers for digital futures.Read moreRead less
Out-of-field Teaching: Sustaining Quality Practices Across Subjects. Teaching out-of-field (teaching a subject without qualifications) is a rising concern internationally, and is linked to attrition, stress, and reduced student learning outcomes. With a comparatively high percentage of out-of-field teachers, Australia is exposed to significant social, economic and educational costs. Through the development of longitudinal case studies, this project investigates the changing landscape of teacher ....Out-of-field Teaching: Sustaining Quality Practices Across Subjects. Teaching out-of-field (teaching a subject without qualifications) is a rising concern internationally, and is linked to attrition, stress, and reduced student learning outcomes. With a comparatively high percentage of out-of-field teachers, Australia is exposed to significant social, economic and educational costs. Through the development of longitudinal case studies, this project investigates the changing landscape of teacher perceptions and practices over three years, within school institutional cultures relating to teacher assignment, support, and out-of-field mathematics and science teaching. Outcomes of the project will aim to inform the development of system and school policy and practice, in dealing with this internationally pervasive issue.Read moreRead less