An Investigation Of The Involvement Of Clotting Factors In Abdominal Aortic Aneurysm (AAA) Progression Within A Mouse Model
Funder
National Health and Medical Research Council
Funding Amount
$189,401.00
Summary
Early stage weakening of the main abdominal artery is present in ~100,000 Australians and currently has no accepted therapy. Development of drug therapies which limit progression of the weakening process is urgently needed. In this study involvement of the clotting cascade in artery weakening will be investigated. The study have been planned in order to identify new strategies which can be developed as treatments for artery weakening in patients.
The primary aim of this grants to determine how HIV spreads through our immune system. The above knowledge will determine key Achille’s Heel moments in the HIV life cycle and thus lead to better therapeutic HIV treatments/prevention.
Many infants and children suffer from bowel motility disorders, for example, chronic constipation affects up to 1 in 10 children. However, the cause of many of these paediatric motility disorders remains unknown. In this project, we will examine the development of wiring of the nervous system that controls bowel motility. This is the first study to investigate the development of cell-cell communication during early stages of nervous system development.
The Role Of Co-signalling Receptors In Cytotoxic Lymphocyte Activity During Infection And Cancer
Funder
National Health and Medical Research Council
Funding Amount
$739,657.00
Summary
Cytotoxic lymphocytes (CLs) are immune cells that detect and kill cancer cells. CLs recognise ‘stress’ proteins on cancer cells through specialised receptors, and this provides the signal for them to kill. However, some cancer cells, such as leukemic cells, can interfere with this recognition to avoid killing by immune cells. This project will investigate the mechanism of recognition and killing of cancer cells by CLs, using both mouse models and cells from patients with acute myeloid leukemia.
Asymptotic Geometric Analysis and Learning Theory. Learning Theory is used in various real-world applications in diverse research areas, ranging from Biology (e.g. DNA sequencing) to Information Sciences. Therefore, having a deep understanding of fundamental questions in Learning Theory, and in particular, pin-pointing the parameters that make a learning problem hard would have a significant practical impact. This projects aims to achieve this goal, and in addition, we expect it would have a hig ....Asymptotic Geometric Analysis and Learning Theory. Learning Theory is used in various real-world applications in diverse research areas, ranging from Biology (e.g. DNA sequencing) to Information Sciences. Therefore, having a deep understanding of fundamental questions in Learning Theory, and in particular, pin-pointing the parameters that make a learning problem hard would have a significant practical impact. This projects aims to achieve this goal, and in addition, we expect it would have a high theoretical value, as the questions we shall address are of independent interest to pure mathematicians.Read moreRead less
Asymptotic Geometric Analysis and Learning Theory. Learning Theory is used in various real-world applications in diverse research areas, ranging from Biology (e.g. DNA sequencing) to Information Sciences. Therefore, having a deep understanding of fundamental questions in Learning Theory, and in particular, pin-pointing the parameters that make a learning problem hard would have a significant practical impact. This projects aims to achieve this goal, and in addition, we expect it would have a hig ....Asymptotic Geometric Analysis and Learning Theory. Learning Theory is used in various real-world applications in diverse research areas, ranging from Biology (e.g. DNA sequencing) to Information Sciences. Therefore, having a deep understanding of fundamental questions in Learning Theory, and in particular, pin-pointing the parameters that make a learning problem hard would have a significant practical impact. This projects aims to achieve this goal, and in addition, we expect it would have a high theoretical value, as the questions we shall address are of independent interest to pure mathematicians.
Read moreRead less
Innovative hands-free technology to give the severely disabled greater mobility control. Half of the serious neurological injuries in Australia result in tetraplegia. Combined with other disabilities that involve severe mobility impairments the cost to the community economically, psychologically and socially is huge. This new Australian technology will facilitate effective sharing of control between a disabled person and a computer control system, taking advantage of their unique strengths and e ....Innovative hands-free technology to give the severely disabled greater mobility control. Half of the serious neurological injuries in Australia result in tetraplegia. Combined with other disabilities that involve severe mobility impairments the cost to the community economically, psychologically and socially is huge. This new Australian technology will facilitate effective sharing of control between a disabled person and a computer control system, taking advantage of their unique strengths and enabling each to aid the other in areas of weakness. The social and personal benefits are potentially very large. Scope also exists to significantly reduce healthcare costs and to develop a new industry in hands-free technology.Read moreRead less
Cohort discovery and activity mining for policy impact prediction. Cohort discovery and activity mining for policy impact prediction. This project aims to develop an intelligent systematic framework to predict policy impacts on Australian patients, by discovering inherent patient cohorts and assessing the impact of the policies on these cohorts. The proposed methods lay the theoretical foundations for building intelligent automated tools for policy assessment. Expected outcomes are data-driven p ....Cohort discovery and activity mining for policy impact prediction. Cohort discovery and activity mining for policy impact prediction. This project aims to develop an intelligent systematic framework to predict policy impacts on Australian patients, by discovering inherent patient cohorts and assessing the impact of the policies on these cohorts. The proposed methods lay the theoretical foundations for building intelligent automated tools for policy assessment. Expected outcomes are data-driven patient group discovery, which could more precisely identify the patient cohorts most likely to benefit from a specific policy; and a model to predict the efficacy of policy options, which could increase the sustainability of the national health system by enabling smarter, more efficient policy decision-making.Read moreRead less
Robust face detection and recognition for computer-based security surveillance. The research aims at improving the existing and creating new automated face detection and recognition methods by making them invariant, firstly to head pose, orientation, scale and rotation, and then to occlusion, lighting conditions and facial expressions.
A robust face detector will be developed first and then a new face recognition algorithm that continues to learn identity-specific discriminants on-line by co ....Robust face detection and recognition for computer-based security surveillance. The research aims at improving the existing and creating new automated face detection and recognition methods by making them invariant, firstly to head pose, orientation, scale and rotation, and then to occlusion, lighting conditions and facial expressions.
A robust face detector will be developed first and then a new face recognition algorithm that continues to learn identity-specific discriminants on-line by collecting incremental face exemplars. The result of the research will be an algorithm that can improve its performance on-line adapting in a stable learning process each identity model to the correct facial examples.
The research has significant practical implication in visual surveillance increasing the robustness of identification of person identity, state and intent.
Read moreRead less
Intruder alert! detecting and classifying events in noisy time series. This project aims to address the mathematical challenges in automated early detection and classification of intrusion events in noisy time series generated from perimeter security systems. The project expects to develop robust methods to detect intrusion events under different operating environments while ignoring nuisance events. The project will boost the global competitiveness of the Australian security industry, and enabl ....Intruder alert! detecting and classifying events in noisy time series. This project aims to address the mathematical challenges in automated early detection and classification of intrusion events in noisy time series generated from perimeter security systems. The project expects to develop robust methods to detect intrusion events under different operating environments while ignoring nuisance events. The project will boost the global competitiveness of the Australian security industry, and enable improved event detection and classification in noisy time series to the benefit of many critical application areas beyond national security.Read moreRead less