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Human Factors And Patient Safety During Paediatric Heart Surgery: An Evidence-based Approach To Improve Patient Outcomes
Funder
National Health and Medical Research Council
Summary
The research project aims to improve outcomes of children undergoing repair of heart birth defects. The novel study is devised to engage health care providers in the re-design of surgical interventions to improve child outcomes. The collaborative approach of engaging health care providers and carers in the design of improvement interventions can help overcome the implementation gap and ensure rapid improvement and enhanced patient safety of children undergoing heart surgery repair.
Application Of Genomic Technologies For The Diagnosis And Management Of Genetic Heart Diseases.
Funder
National Health and Medical Research Council
Funding Amount
$438,768.00
Summary
The purpose of this research study is to investigate clinical and genetic factors which may predispose to important cardiac events such as dangerous arrhythmias, heart failure, heart transplantation or sudden cardiac death in patients with genetic heart diseases. It is possible that there are important risk factors or genetic findings which may be identified either through newer technologies which help cardiologists determine which patients and families are most at risk.
Value-Based Healthcare In Elective Coronary Stenting
Funder
National Health and Medical Research Council
Funding Amount
$1,236,881.00
Summary
Coronary stents are wire mesh tubes inserted into cholesterol blockages in heart blood vessels (arteries) thus improving coronary blood flow and alleviating chest pain. Although life saving in acute heart attacks, their value is limited in stable patients and may be associated with severe complications. In partnership with the health department, this project will evaluate how many patients continue to experience chest pain after elective coronary stenting so that can be used more effectively.
Fenofibrate In The Management Of AbdoMinal Aortic AnEurysm (FAME)
Funder
National Health and Medical Research Council
Funding Amount
$455,713.00
Summary
Approximately 5% of men and 1% of women aged over 60 years develop weakening of the main abdominal artery. Currently the management of artery weakening is focused on surgery with no effective medications available. In this study we will assess whether a drug which limits artery weakening in pre-clinical testing also shows evidence of inhibiting processes important in artery damage in patients. We believe this is a critical next step in the assessment of a promising new treatment.
Which Heart Failure Intervention Is Most Cost Effective In Reducing Hospital Care (WHICH? II) Trial: A Multicentre, Randomised Trial Of Standard Versus Intensified Management Of Metropolitan And Regional-dwelling Patients With Heart Failure
Funder
National Health and Medical Research Council
Funding Amount
$1,891,210.00
Summary
Chronic heart failure (CHF) management programs are now the gold-standard to cost-effectively care for thousands of Australians hospitalised with CHF each year. We’ve shown that home-based management is most cost-effective in reducing hospital stay in CHF. The Which Intervention is most Cost-effective in reducing Hospital care (WHICH? II) Trial, a multicentre, randomised study, will determine if more intensive care (via home visits and remote care contacts) further improves poor outcomes in CHF.
Mechanisms, Biomarkers And New Therapies For Abdominal Aortic Aneurysm
Funder
National Health and Medical Research Council
Funding Amount
$551,370.00
Summary
Approximately 5% of men and 1% of women aged over 60 years develop artery weakening. The management of artery weakening is currently focused on radiological imaging and surgery. In this fellowship work will be performed to better understand the mechanisms involved in artery weakening, assess new ways of monitoring disease progression and evaluate new medical therapies. It is envisaged that the work will identify a number of new management stratergies for this common condition.
Non-Inasive Wave Intensity Analysis In Paediatric Congenital Heart Disease: A Novel Application Of Cardiac Magnetic Resonance Imaging
Funder
National Health and Medical Research Council
Funding Amount
$136,861.00
Summary
Alterations in heart pumping function, or blood vessel structure, can limit the supply of blood and oxygen to the body. Wave Intensity Analysis (WIA) is a new way of characterising these interactions with great precision. Up until now, WIA has been performed in adult and animal studies using mainly invasive techniques. This project will develop a non-invasive method for WIA using cardiac Magnetic Resonance Imaging, to gain new insights into congenital heart disease in children.
Evaluating Coronary Stents Using High-resolution Optical Coherence Tomography Imaging In Patients With Coronary Artery Disease
Funder
National Health and Medical Research Council
Funding Amount
$217,274.00
Summary
A stent is a device made of metal that is placed inside an artery to prop it. Recently, the applicant introduced into Australia a novel technology to examine these stents once inside the body. This information may help make stents safer for patients
A Randomized Comparison Evaluating The Value Of High-sensitivity Troponin In The Efficient Management Of Chest Pain Patients Across The Spectrum Of Risk For An Acute Coronary Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$508,567.00
Summary
Chest pain patients are a large burden of emergency department demand. Their effective care requires timely risk assessment. High-sensitivity assays for cardiac muscle damage (troponin) increases the ability to detect patients with heart attacks, but may also lead to more abnormal results from other causes and more admissions. This randomized trial of current troponin versus a new troponin assays with robust initial evaluation of patient risk will provide a rationale for their use in modern care ....Chest pain patients are a large burden of emergency department demand. Their effective care requires timely risk assessment. High-sensitivity assays for cardiac muscle damage (troponin) increases the ability to detect patients with heart attacks, but may also lead to more abnormal results from other causes and more admissions. This randomized trial of current troponin versus a new troponin assays with robust initial evaluation of patient risk will provide a rationale for their use in modern care.Read moreRead less