Mosquito-borne alphaviruses such as Ross River and chikungunya viruses cause widespread epidemics and exert extreme pressure on the public health systems of affected regions. Alphaviruses spreads to joints and triggers a severe disease in those affected. There are no effective treatments or vaccines. The project will investigate virus-host interaction at the bite site. The outcome will be new knowledge to treat infection at the mosquito bite site to prevent joint disease.
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
New Insights Into Viral Inflammatory Disease Mechanisms And Approaches To Therapy
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This fellowship aims to establish how viruses cause disease, including how they evade the immune response to persist and cause disease for prolonged periods. My vision is that knowing how the virus and the immune system interact to determine disease severity will assist in devising new treatments and prevention programs to lessen the impact of viral diseases in Australia and worldwide.
Beyond Scenarios: Testable Models of the Evolution of Norms. The aim of this project is to investigate the evolution of social norms, and their causal role in social life and its breakdown. It expects to generate new knowledge in this area through the application of new formal techniques to existing hypotheses; especially causal analysis, evolutionary game theory, and phylogenetic cross-cultural testing for empirically plausibility. Expected outcomes include theory development, improved research ....Beyond Scenarios: Testable Models of the Evolution of Norms. The aim of this project is to investigate the evolution of social norms, and their causal role in social life and its breakdown. It expects to generate new knowledge in this area through the application of new formal techniques to existing hypotheses; especially causal analysis, evolutionary game theory, and phylogenetic cross-cultural testing for empirically plausibility. Expected outcomes include theory development, improved research infrastructure and training in collaboration with international partners, and theoretical recommendations for policy intervention. This should allow greater insight and control over the levers of peaceful social life, both in traditional societies, and in large, open, multi-cultural nations like Australia. Read moreRead less
The Indian Roots of Modern Chinese Thought. The Project will strengthen Australia's capacity to interpret and engage with our regional and global environments by demonstrating the need for greater understanding of the nationalistic appeal that Yogâcâra thought has held for Chinese intellectuals; and the rise of New Confucianism as a philosophical movement associated with robust expressions of cultural nationalism. It will also further enhance Australia's international intellectual profile by bri ....The Indian Roots of Modern Chinese Thought. The Project will strengthen Australia's capacity to interpret and engage with our regional and global environments by demonstrating the need for greater understanding of the nationalistic appeal that Yogâcâra thought has held for Chinese intellectuals; and the rise of New Confucianism as a philosophical movement associated with robust expressions of cultural nationalism. It will also further enhance Australia's international intellectual profile by bringing together leading researchers to forge innovative research networks and methodologies to advance the knowledge bases of Chinese intellectual history, Chinese Philosophy and Buddhist Studies, and contribute to building Australian research capacity in these three key areas.Read moreRead less
Changing your mind by changing your brain: An interventionist perspective on cognitive neuroscience. Functional neuroimaging provides a tremendous amount of information about the brain, but what it shows about the mind is less clear. Addressing this fundamental philosophical question requires developing a detailed account of theory-testing in cognitive neuroscience. This project aims to connect neuroimaging to theories of explanation that focus on the way one variable can make a difference to an ....Changing your mind by changing your brain: An interventionist perspective on cognitive neuroscience. Functional neuroimaging provides a tremendous amount of information about the brain, but what it shows about the mind is less clear. Addressing this fundamental philosophical question requires developing a detailed account of theory-testing in cognitive neuroscience. This project aims to connect neuroimaging to theories of explanation that focus on the way one variable can make a difference to another. By linking neuroimaging to facts about manipulable relationships between the brain and the mind, it will also provide a bridge between neuroimaging and complementary technologies for directly intervening on the brain. This, in turn, will provide a platform from which to explore the theoretical and ethical consequences of direct brain manipulation.Read moreRead less
The Formation and Development of Chinese Philosophy as an Academic Discipline in Twentieth Century China. It is in Australia's national interest to pay close attention to the orientation of intellectual and political currents in China and to how these currents are increasingly merging and interacting. This project will enhance our capacity to interpret and engage with our regional environment by contributing to a clearer understanding of the changing relationship between Chinese intellectual tra ....The Formation and Development of Chinese Philosophy as an Academic Discipline in Twentieth Century China. It is in Australia's national interest to pay close attention to the orientation of intellectual and political currents in China and to how these currents are increasingly merging and interacting. This project will enhance our capacity to interpret and engage with our regional environment by contributing to a clearer understanding of the changing relationship between Chinese intellectual traditions and cultural identity. A commitment to understanding what Chinese philosophy means to China's educated elite also demonstrates a willingness to foster dialogue and communication that is sensitive to the intellectual and cultural traditions which are a source of pride and identity for several of our major regional partners. Read moreRead less
The Intellectual Construction of Confucianism in Contemporary China and Taiwan. Since the 1980s China and Taiwan have witnessed the most sustained resurgence of intellectual interest in Confucianism of the twentieth century. This project will provide the first critical analysis of that revival by addressing the complex interaction of institutional, philosophical and ideological factors, rather than study one or the other in isolation. This will enable us to understand the processes by which Chi ....The Intellectual Construction of Confucianism in Contemporary China and Taiwan. Since the 1980s China and Taiwan have witnessed the most sustained resurgence of intellectual interest in Confucianism of the twentieth century. This project will provide the first critical analysis of that revival by addressing the complex interaction of institutional, philosophical and ideological factors, rather than study one or the other in isolation. This will enable us to understand the processes by which Chinese intellectuals have sought to make Confucianism a viable philosophical and cultural resource in the modern world; and to evaluate how successful they have been in achieving these goals.
Results: One monograph; one edited volume; several essays.
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