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Identification Of Novel Therapeutic Binding Sites On Glycine Receptors By High Throughput Screening
Funder
National Health and Medical Research Council
Funding Amount
$542,017.00
Summary
Glycine receptors mediate inhibitory neurotransmission in the nervous system. They provide fresh therapeutic targets for chronic inflammatory pain and muscle spasticity. Here we identify 5 compounds that may be appropriate as leads for discovering novel therapies for these disorders. We will use automated high throughput screening methods to discover how these drugs interact with the receptor. This will narrow down the search for the next generation of analgesic and muscle relaxant drugs.